The problem of global development of antibiotic resistant nosocomial pathogens


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Abstract

The problem of global expansion of multidrug-resistant nosocomial infections pathogens is under special attention at the moment. Antibiotic resistance increasing give us the limited treatment options. This problem is particularly acute for transplant clinics, because of patients need lifelong immunosuppressive therapy. From the one hand this ensures stable allograft functioning, but from the other – increases the risk of severe infectious complications in the postoperative period. The purpose of this article is analysis carbapenem resistance dynamics of Klebsiella spp., Acinetobacter spp., Pseudomonas spp. and Staphylococcus spp. isolated from the blood of recipients of donor organs from 2009 to 2019 in the Shumakov National Medical Research Center of Transplantology and Artificial Organs. A significant annual decrease of carbapenem-sensitive strains of Klebsiella spp. and Acinetobacter spp. are shown. The study of a distinctive pathogen resistance profile specific to each institution can help one in selecting an adequate antimicrobial strategy and is an effective predictive tool for controlling the growth of multidrug-resistant microorganisms.

About the authors

N. I. Gabrielyan

Shumakov National Medical Research Center of Transplantology and Artificial Organs

Author for correspondence.
Email: labgso@mail.ru
ORCID iD: 0000-0003-1941-8311

д.м.н., зав. отд. эндотоксикозов и гнойно-септических осложнений

Russian Federation, Moscow

S. О. Sharapchenko

Shumakov National Medical Research Center of Transplantology and Artificial Organs

Email: labgso@mail.ru
ORCID iD: 0000-0001-9295-9136

лаборант-исследователь отд. регуляторных механизмов в трансплантологии

Russian Federation, Moscow

О. V. Kisil

Gause Institute of New Antibiotics

Email: labgso@mail.ru
ORCID iD: 0000-0003-4799-1318

к.м.н., ученый секретарь

Russian Federation, Moscow

V. G. Kormilitsina

Shumakov National Medical Research Center of Transplantology and Artificial Organs

Email: labgso@mail.ru
ORCID iD: 0000-0002-6475-3904

лаборант-исследователь лаб. бактериологии отд. эндотоксикозов и гнойно-септических осложнений

Russian Federation, Moscow

I. V. Drabkina

Shumakov National Medical Research Center of Transplantology and Artificial Organs

Email: labgso@mail.ru
ORCID iD: 0000-0002-9528-3490

врач-бактериолог лаб. бактериологии отд. эндотоксикозов и гнойно-септических осложнений

Russian Federation, Moscow

Т. B. Safonova

Russian Medical Academy of Continuous Professional Education

Email: labgso@mail.ru
ORCID iD: 0000-0002-7447-372X

канд. мед. наук, доц. каф. микробиологии

Russian Federation, Moscow

М. I. Petrukhina

Russian Medical Academy of Continuous Professional Education

Email: labgso@mail.ru
ORCID iD: 0000-0001-9754-4765

канд. мед. наук, доц. каф. эпидемиологии

Russian Federation, Moscow

R. Sh. Saitgareev

Shumakov National Medical Research Center of Transplantology and Artificial Organs

Email: labgso@mail.ru
ORCID iD: 0000-0001-9754-4765

д.м.н., проф., зав. кардиохирургическим отд-нием №1

Russian Federation, Moscow

V. М. Zakharevich

Shumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov First Moscow State Medical University (Sechenov University)

Email: labgso@mail.ru
ORCID iD: 0000-0002-1090-6901

д.м.н., зав. отд. эндотоксикозов и гнойно-септических осложнений

Russian Federation, Moscow

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Supplementary files

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2. Figure: 1. The mortality rate from 2015 to 2018 among recipients of solid organs with bacterial blood infection caused by A. baumannii and K. pneumoniae (%).

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3. Figure: 2. Diagram of susceptibility to imipenem and meropenem of strains of Acinetobacter spp. (a) and Klebsiella spp. (b) isolated from the blood of patients from 2009 to 2019.

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4. Figure: 3. Diagram of susceptibility to imipenem and meropenem of Pseudomonas spp. (a) and Staphylococcus spp. (b) isolated from the blood of patients from 2009 to 2019.

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