The role of vitamin D in seasonal acute respiratory viral infections and COVID-19
- Authors: Pigarova E.A.1, Povalyaeva A.A.1, Dzeranova L.K.1, Rozhinskaya L.Y.1, Mokrysheva N.G.1
-
Affiliations:
- Endocrinology Research Centre
- Issue: Vol 92, No 11 (2020)
- Pages: 98-105
- Section: Reviews
- URL: https://journals.rcsi.science/0040-3660/article/view/56945
- DOI: https://doi.org/10.26442/00403660.2020.11.000785
- ID: 56945
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Abstract
A link between vitamin D deficiency and susceptibility to infectious diseases was suggested over a hundred years ago. Epidemiological studies show a strong association between seasonal fluctuations in vitamin D levels and the incidence of various infectious diseases, including septic shock, acute respiratory infections, and influenza. Our understanding of vitamin D metabolism and its extra-skeletal functions has improved significantly over the past three decades, and the discovery that the vitamin D receptor and 1a-hydroxylase, an enzyme needed to convert vitamin D to its active form, is present in the cells of the immune system, revolutionized in this area. Recent studies have shown that vitamin D regulates the expression of specific endogenous antimicrobial peptides in immune cells, modulates the immune response and the course of autoimmune processes; these actions indicate the potential role of vitamin D in modulating the immune response to various infectious diseases. This publication reviews the literature on the effects of vitamin D on immunity, its potential in the prevention and treatment of viral diseases, with a particular focus on COVID-19.
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##article.viewOnOriginalSite##About the authors
E. A. Pigarova
Endocrinology Research Centre
Author for correspondence.
Email: kpigarova@gmail.com
ORCID iD: 0000-0001-6539-466X
д.м.н., и.о. дир. Института высшего и дополнительного профессионального образования
Russian Federation, MoscowA. A. Povalyaeva
Endocrinology Research Centre
Email: kpigarova@gmail.com
ORCID iD: 0000-0002-7634-5457
ассистент Центра аккредитации и симуляционного обучения Института высшего и дополнительного профессионального образования
Russian Federation, MoscowL. K. Dzeranova
Endocrinology Research Centre
Email: kpigarova@gmail.com
ORCID iD: 0000-0002-0327-4619
д.м.н., гл. науч. сотр. отд-ния нейроэндокринологии и остеопатий
Russian Federation, MoscowL. Y. Rozhinskaya
Endocrinology Research Centre
Email: kpigarova@gmail.com
ORCID iD: 0000-0001-7041-0732
д.м.н., проф., гл. науч. сотр. отд-ния нейроэндокринологии и остеопатий
Russian Federation, MoscowN. G. Mokrysheva
Endocrinology Research Centre
Email: kpigarova@gmail.com
ORCID iD: 0000-0002-9717-9742
чл.-кор. РАН, д.м.н., дир.
Russian Federation, MoscowReferences
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