Inguinal lymphadenitis due to invasion of Dirofilaria repens


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Abstract

The paper presents the case of the right-sided inguinal inflammation of a lymph node as a result of invasion of Dirofilaria repens, the parasitic pathogen of subcutaneous dirofilariasis in animals of the canine family. The diagnosis was verified on the basis of the parallel application of morphological studies of cross sections of the nematode in histological samples and the molecular biological method – polymerase chain reaction of scrapings of histological material. The localization of this helminth inside the cavities of the human body is extremely rare. Only isolated cases of atypical localization of D. repens are described: in the organs of the chest, cervical lymphatic node in the spermatic cord and epididymis, which led to pseudotumor formations that needed to be differentiated with neoplastic processes. This case is of great interest to experts of various fields (surgeons, oncologists, infectious disease specialists and pathologists), primarily in the differential diagnosis of malignant neoplasms of the lymphatic system.

About the authors

L. A. Ermakova

Rostov Research Institute of Microbiology and Parasitology; Rostov State Medical University

Author for correspondence.
Email: ya.parazitov-net@yandex.ru
ORCID iD: 0000-0002-8918-2271

к.м.н., зав. клиникой инфекционных и паразитарных болезней, врач-инфекционист, ассистент каф. фтизиатрии, пульмонологии и инфекционных болезней

Russian Federation, Rostov-on-Don

S. A. Nagorny

Rostov Research Institute of Microbiology and Parasitology

Email: ya.parazitov-net@yandex.ru
ORCID iD: 0000-0001-8487-2313

к.б.н., вед. науч. сотр. лаб. санитарно-паразитологического мониторинга, медицинской паразитологии и иммунологии

Russian Federation, Rostov-on-Don

I. V. Kornienko

Rostov Research Institute of Microbiology and Parasitology; Federal Research Center the Southern Scientific Center of the Russian Academy of Sciences; Southern Federal University

Email: ya.parazitov-net@yandex.ru
ORCID iD: 0000-0003-0274-3302

д.б.н., гл. науч. сотр; зав. науч. лаб. «Идентификация объектов биологического происхождения; биолог клиники инфекционных и паразитарных болезней 

Russian Federation, Rostov-on-Don

J. V. Kiosova

Rostov Research Institute of Microbiology and Parasitology

Email: ya.parazitov-net@yandex.ru
ORCID iD: 0000-0002-6142-2624

биолог клиники инфекционных и паразитарных болезней

Russian Federation, Rostov-on-Don

S. S. Todorov

Rostov State Medical University

Email: ya.parazitov-net@yandex.ru
ORCID iD: 0000-0001-8476-5606

д.м.н., рук. морфологического отд. клиники

Russian Federation, Rostov-on-Don

N. Yu. Pshenichnaya

Rostov State Medical University; Central Research Institute of Epidemiology

Email: ya.parazitov-net@yandex.ru
ORCID iD: 0000-0003-2570-711X

д.м.н., проф., зам. дир. по клин.-аналитической работе

Russian Federation, Rostov-on-Don; Moscow

References

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2. Figure: 1. Histological preparation of the right inguinal lymph node of patient S. (Description of the preparation: in the center of the lymph node there are two transverse sections of dirofilaria, which have a cuticular membrane with a surrounding expressed neutrophilic infiltration, macrophage infiltration of the stroma, chronic purulent inflammation, with an accumulation of neutrophils, giant multinucleated cells of the type of foreign with the development of granulation tissue. (Hematoxylin-eosin staining * 100, 200, 400)

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3. Figure: 2. Cross section of a nematode with comb-like cuticular outgrowths.

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4. Figure: 3. Products of amplification of DNA images.

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