Early postoperative measurement of growth hormone level for prognosis of surgical outcomes in acromegaly
- Authors: Tsiberkin A.I.1, Tsoy U.A.1, Cherebillo V.Y.1, Polezhaev A.V.1, Kuritsyna N.V.1, Paltsev A.A.1, Alkhazishvili A.V.1, Grineva E.N.1
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Affiliations:
- Almazov National Medical Research Center
- Issue: Vol 92, No 10 (2020)
- Pages: 48-53
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/50976
- DOI: https://doi.org/10.26442/00403660.2020.10.000490
- ID: 50976
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Abstract
Aim. To investigate the value of 24 hours post-surgery measurement of growth hormone (GH) level for prognosis of surgical outcomes in acromegaly.
Materials and methods. A prospective cohort study included 45 patients with newly diagnosed acromegaly. The degree of parasellar extension was measured on the preoperative sellar magnetic resonance imaging according to the Knosp’s classification. All patients underwent a transsphenoid adenomectomy performed by one neurosurgeon. Basal GH level was measured at 24 hours after surgery. The efficacy of transsphenoidal adenomectomy evaluated at 12 months after surgery.
Results. Acromegaly remission was achieved in 19 (42%) of 45 patients at 12 months after surgery. Pituitary microadenomas and the absence of paracellular invasion, corresponding to Knosp Grade 0–2, had low prognostic value for long-term remission due to low sensitivity (31.6%) and low specificity (38.5%), respectively. The highest prognostic value for acromegaly remission was showed for 24 hours post-surgery GH level with cut-off <1.30 ng/ml with sensitivity of 96.2% (95% confidence interval 81.1–99.8%) and specificity of 84.2% (95% confidence interval 62.4–94.4%).
Conclusion. The study demonstrated the possibility of using GH level at 24 after surgery as a predictor for acromegaly remission. GH level <1.30 ng/ml at 24 hours after surgery showed better predictive value for long-term remission compared with the presence of microadenomas and Knosp Grade 0–2. The absence of decrease of GH level on the first day after surgery may serve as a reason for more close monitoring of patients in the postoperative period. Further studies in a larger number of observers are required to confirm our findings.
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##article.viewOnOriginalSite##About the authors
A. I. Tsiberkin
Almazov National Medical Research Center
Author for correspondence.
Email: tsibern1@gmail.com
ORCID iD: 0000-0001-6587-4313
врач-эндокринолог, мл. науч. сотр. НИЛ нейроэндокринологии
Russian Federation, Saint PetersburgU. A. Tsoy
Almazov National Medical Research Center
Email: tsibern1@gmail.com
ORCID iD: 0000-0003-4013-4831
к.м.н., зав. НИЛ нейроэндокринологии
Russian Federation, Saint PetersburgV. Yu. Cherebillo
Almazov National Medical Research Center
Email: tsibern1@gmail.com
ORCID iD: 0000-0001-6803-9954
д.м.н., проф., врач-нейрохирург отд-ния нейрохирургии №6
Russian Federation, Saint PetersburgA. V. Polezhaev
Almazov National Medical Research Center
Email: tsibern1@gmail.com
ORCID iD: 0000-0001-9450-1516
к.м.н., науч. сотр. НИЛ нейроэндокринологии
Russian Federation, Saint PetersburgN. V. Kuritsyna
Almazov National Medical Research Center
Email: tsibern1@gmail.com
ORCID iD: 0000-0003-1337-1719
врач-эндокринолог ЛРК-1
Russian Federation, Saint PetersburgA. A. Paltsev
Almazov National Medical Research Center
Email: tsibern1@gmail.com
ORCID iD: 0000-0002-9966-2965
к.м.н., зав. отд-нием нейрохирургии №6
Russian Federation, Saint PetersburgA. V. Alkhazishvili
Almazov National Medical Research Center
Email: tsibern1@gmail.com
ORCID iD: 0000-0002-7250-6786
аспирант каф. лучевой диагностики и медицинской визуализации, врач-рентгенолог детского ЛРК
Russian Federation, Saint PetersburgE. N. Grineva
Almazov National Medical Research Center
Email: tsibern1@gmail.com
ORCID iD: 0000-0003-0042-7680
д.м.н., проф., дир. Института эндокринологии
Russian Federation, Saint PetersburgReferences
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