The agreed experts’ position of the Eurasian Association of Therapists on tactics of management of patients with comorbid pathology infected with SARS-Cov-2
- Authors: Arutiunov G.P.1, Tarlovskaia E.I.2, Koziolova N.A.3, Boldina M.V.2, Batiushin M.M.4, Ametov A.S.5, Arutiunov A.G.1, Belevskii A.S.1, Galstian G.R.6, Grigor’eva N.I.2, Dzhunusbekova G.A.7, Esaian A.M.8, Mal’chikova S.V.9, Mit’kovskaia N.P.10, Mkrtumian A.M.11, Orlova I.A.12, Petrova M.M.13, Rebrov A.P.14, Ruzanov D.I.15, Salukhov V.V.16, Sisakian A.S.17, Skibitskii V.V.18, Sugraliev A.B.19, Fomin I.V.2, Khalimov I.S.16, Chesnikova A.I.4, Shaposhnik I.I.20, Shestakova M.V.6
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Affiliations:
- Pirogov Russian National Research Medical University
- Volga Research Medical University
- Wagner Perm State Medical University
- Rostov State Medical University
- Russian Medical Academy of Continuous Professional Education
- Endocrinology Research Centre
- Kazakh Medical University of Continuing Education
- Pavlov First Saint Petersburg State Medical University
- Kirov State Medical University
- Belarusian State Medical University
- Yevdokimov Moscow State University of Medicine and Dentistry
- Lomonosov Moscow State University
- Voino-Yasenetski Krasnoyarsk State Medical University
- Razumovsky Saratov State Medical University
- Gomel State Medical University
- Kirov Military Medical Academy
- Yerevan State Medical University
- Kuban State Medical University
- Asfendiyarov Kazakh National Medical University
- South Ural State Medical University
- Issue: Vol 92, No 9 (2020)
- Pages: 108-124
- Section: Consensuns
- URL: https://journals.rcsi.science/0040-3660/article/view/46864
- DOI: https://doi.org/10.26442/00403660.2020.09.000703
- ID: 46864
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Abstract
The agreement of experts of the Eurasian Association of Therapists (EAT) discusses pathogenesis and treatment of COVID-19. Modern data on the characteristics of cardiovascular, kidney, respiratory damage in SARS-infected CoV-2 are presented. The tactics of managing patients initially having cardiovascular diseases, diabetes mellitus, chronic obstructive pulmonary disease, bronchial asthma, chronic kidney disease are discussed in detail. The article presents data on drug interaction of drugs.
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##article.viewOnOriginalSite##About the authors
G. P. Arutiunov
Pirogov Russian National Research Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-9659-7010
чл.-кор. РАН, д.м.н., зав. каф. внутренних болезней и общей физиотерапии ФГАОУ ВО «РНИМУ им. Н.И. Пирогова»
Russian Federation, MoscowE. I. Tarlovskaia
Volga Research Medical University
Author for correspondence.
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-9659-7010
д.м.н., проф., зав. каф. терапии и кардиологии ФГБОУ ВО ПИМУ
Russian Federation, Nizhny NovgorodN. A. Koziolova
Wagner Perm State Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0001-7003-5186
д.м.н., проф., зав. каф. пропедевтики внутренних болезней №2 ФГБОУ ВО «ПГМУ им. акад. Е.А. Вагнера»
Russian Federation, PermM. V. Boldina
Volga Research Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-1794-0707
к.м.н., рук. Городского пульмонологического консультативного центра г. Нижнего Новгорода, ассистент каф. терапии и кардиологии ФГБОУ ВО ПИМУ
Russian Federation, Nizhny NovgorodM. M. Batiushin
Rostov State Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-2733-4524
д.м.н., проф. каф. внутренних болезней №2, зав. нефрологическим отд-нием ФГБОУ ВО РостГМУ
Russian Federation, Rostov-on-DonA. S. Ametov
Russian Medical Academy of Continuous Professional Education
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-7936-7619
д.м.н., проф., зав. каф. эндокринологии ФГБОУ ДПО РМАНПО
Russian Federation, MoscowA. G. Arutiunov
Pirogov Russian National Research Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0003-1180-3549
д.м.н., доц., проф. каф. внутренних болезней и общей физиотерапии ФГАОУ ВО «РНИМУ им. Н.И. Пирогова»
Russian Federation, MoscowA. S. Belevskii
Pirogov Russian National Research Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0001-6050-724X
д.м.н., проф. каф. пульмонологии ФГБОУ ВО «РНИМУ им. Н.И. Пирогова»
Russian Federation, MoscowG. R. Galstian
Endocrinology Research Centre
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0001-6581-4521
д.м.н., проф., и.о. зам. дир. Института диабета, зав. отд-нием диабетической стопы ФГБУ «НМИЦ эндокринологии»
Russian Federation, MoscowN. I. Grigor’eva
Volga Research Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0001-6795-7884
д.м.н., доц., зав. каф. факультетской и поликлинической терапии ФГБОУ ВО ПИМУ
Russian Federation, Nizhny NovgorodG. A. Dzhunusbekova
Kazakh Medical University of Continuing Education
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0001-7452-5625
д.м.н., проф., зав. каф. кардиологии КМУПО
Kazakhstan, AlmatyA. M. Esaian
Pavlov First Saint Petersburg State Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-7202-3151
д.м.н., проф., зав. каф. нефрологии и диализа ФПО ФГБОУ ВО «Первый СПб ГМУ им. акад. И.П. Павлова»
Russian Federation, Saint PetersburgS. V. Mal’chikova
Kirov State Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-9088-721X
д.м.н., проф., зав. каф. кардиологии и внутренних болезней БГМУ
Russian Federation, KirovN. P. Mit’kovskaia
Belarusian State Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-9088-721X
д.м.н., проф., зав. каф. кардиологии и внутренних болезней БГМУ
Belarus, MinskA. M. Mkrtumian
Yevdokimov Moscow State University of Medicine and Dentistry
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0003-1316-5245
д.м.н., проф., зав. каф. эндокринологии и диабетологии лечебного фак-та ФГБОУ ВО «МГМСУ им. А.И. Евдокимова»
Russian Federation, MoscowI. A. Orlova
Lomonosov Moscow State University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-8160-5612
д.м.н., проф., зав. каф. терапии фак-та фундаментальной медицины ФГБОУ ВО «МГУ им. М.В. Ломоносова»
Russian Federation, MoscowM. M. Petrova
Voino-Yasenetski Krasnoyarsk State Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-8493-0058
д.м.н., проф., зав. каф. поликлинической терапии, семейной медицины и ЗОЖ с курсом ПО ФГБОУ ВО «КГМУ им. проф. В.Ф. Войно-Ясенецкого»
Russian Federation, KrasnoyarskA. P. Rebrov
Razumovsky Saratov State Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-3463-7734
д.м.н., проф., зав. каф. госпитальной терапии ФГБОУ ВО «СГМУ им. В.И. Разумовского»
Russian Federation, SaratovD. I. Ruzanov
Gomel State Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0001-5291-4937
к.м.н., доц. каф. пульмонологии и фтизиатрии ГомГМУ
Belarus, GomelV. V. Salukhov
Kirov Military Medical Academy
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0003-1851-0941
д.м.н., проф., нач. 1-й каф. терапии усовершенствования врачей ФГБВОУ ВО «ВМА им. С.М. Кирова»
Russian Federation, Saint PetersburgA. S. Sisakian
Yerevan State Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0003-2986-0525
д.м.н., проф., зав. каф. кардиологии фак-та общей медицины ЕрГМУ
Armenia, YerevanV. V. Skibitskii
Kuban State Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-4855-418X
д.м.н., проф., зав. каф. госпитальной терапии ФГБОУ ВО КГМУ
Russian Federation, KrasnodarA. B. Sugraliev
Asfendiyarov Kazakh National Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-8255-4159
к.м.н., доц., зав. каф. внутренних болезней №1 НАО «КазНМУ им. С.Д. Асфендиярова»
Kazakhstan, AlmatyI. V. Fomin
Volga Research Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0003-0258-5279
д.м.н., доц., зав. каф. госпитальной терапии ФГБОУ ВО ПИМУ
Russian Federation, Nizhny NovgorodI. S. Khalimov
Kirov Military Medical Academy
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-7755-7275
д.м.н., проф., нач. каф. военно-полевой терапии ФГБВОУ ВО «ВМА им. С.М. Кирова»
Russian Federation, Saint PetersburgA. I. Chesnikova
Rostov State Medical University
Email: etarlovskaya@mail.ru
д.м.н., проф., проф. каф. внутренних болезней №1 ФГБОУ ВО РостГМУ
Russian Federation, Rostov-on-DonI. I. Shaposhnik
South Ural State Medical University
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-7731-7730
д.м.н., проф., зав. каф. пропедевтики внутренних болезней ФГБОУ ВО ЮУГМУ
Russian Federation, ChelyabinskM. V. Shestakova
Endocrinology Research Centre
Email: etarlovskaya@mail.ru
ORCID iD: 0000-0002-5057-127X
акад. РАН, д.м.н., проф., зам. дир. ФГБУ «НМИЦ эндокринологии», дир. Института диабета
Russian Federation, MoscowReferences
- Yang J, Zheng Y, Gou X, et al. Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis. Int J Infect Dis. 2020 Mar 12. pii: S1201-9712(20)30136-3. doi: 10.1016/j.ijid.2020.03.017
- Wang B, Li R, Hufng Y, et al. Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis. Aging (Albany NY). 2020 Apr 8;12. doi: 10.18632/aging.103000
- Wei-jie Guan, Wen-hua Liang, Yi Zhao, et al. Comorbidity and its impact on 1590 patients with Covid-19 in China: A Nationwide Analysis. Eur Respir J. 2020. doi: 10.1183/13993003.00547-2020
- Chow N, et al. Preliminary estimates of the prevalence of selected underlying health conditions among patients with coronavirus disease 2019 – United States, February 12–March 28, 2020. MMWR Morb Mortal Wkly Rep 2020 Apr 3;69:382. doi: 10.15585/mmwr.mm6913e2
- Garg S, Kim L, Whitaker M, et al. Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 – COVID-NET, 14 States, March 1–30, 2020. MMWR Morb Mortal Wkly Rep. ePub: 8 April 2020. doi: 10.15585/mmwr.mm6915e3
- The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) – China, 2020. China CDC Weekly. 2020;2(8):10. doi: 10.46234/ccdcw2020.032
- Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) United States, February 12–March 16, 2020. CDC Morbidity and Mortality Weekly Report. 2020;69. doi: 10.15585/mmwr.mm6912e2
- Report sulle caratteristiche dei pazienti deceduti positivi a COVID-19 in Italia Il presente report è basato sui dati aggiornati al 20 Marzo 2020. Istituto Superioe di Sanita, 2020. https://www.epicentro.iss.it/coronavirus/ sars-cov-2-decessi-italia
- Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. J Am Med Assoc. 2020 Mar 23. doi: 10.1001/jama.2020.4683
- Covid-19. Situation au 15 mars 2020 à minuit. Santé publique France, 2020. 18.03.2020. https://www.caducee.net/actualite-medicale/14761/covid-19-le-point-de-situation-epidemiologique-sur-le-coronavirus-sars-cov-2.html
- Ki M. Epidemiologic characteristics of early cases with 2019 novel coronavirus (2019-nCoV) disease in Korea. Epidemiol Health. 2020;42:e2020007. doi: 10.4178/epih.e2020007
- Barns rolle i spredning av SARS-CoV-2 (Covid-19) – en hurtigoversikt. Hurtigoppsummering. Oslo: Folkehelseinstituttet, 2020. 23.03.2020. https://www.fhi.no/globalassets/dokumenterfiler/rapporter/2020/barns-rolle-i-spredning--av-sars-cov-2-covid-19-rapport-2020-v2.pdf
- Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese center for disease Control and prevention. J Am Med Assoc. 2020 Feb 24. doi: 10.1001/jama.2020.2648
- Palmieri L, Andrianou X, Bella A, et al. Characteristics of COVID-19 patients dying in Italy Report based on available data on March 20th, 2020. https://www.epicentro.iss.it/coronavirus/bollettino/Report-COVID-2019_20_marzo_eng.pdf
- Shi S, Qin M, Shen B, et al. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. JAMA Cardiol. 2020 March 25. doi: 10.1001/jamacardio.2020.0950
- Guo T, Fan Y, Chen M, et al. Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020 March 27. doi: 10.1001/jamacardio.2020.1017
- Li B, Yang J, Zhao F, et al. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. Clin Res Cardiol. 2020 Mar 11. doi: 10.1007/s00392-020-01626-9.
- Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential Effects of Coronaviruses on the Cardiovascular System: A Review. JAMA Cardiol. 2020 March 27. doi: 10.1001/jamacardio.2020.1286
- Профилактика, диагностика и лечение новой коронавирусной инфекции (2019-nCoV). Временные методические рекомендации. Минздрав России. Версия V. 08.04.2020 [Prevention, diagnosis and treatment of a new coronavirus infection (2019-nCoV). The provisional guidelines. Ministry of Health of Russia. Version V. 08.04.2020 (In Russ.)]. https://static-1.rosminzdrav.ru/system/attachments/attaches/000/049/951/original/09042020_%D0%9C%D0%A0_COVID-19_v5.pdf
- Шляхто Е.В., Конради А.О., Арутюнов Г. П и др. Руководство по диагностике и лечению болезней системы кровообращения в контексте пандемии COVID-19. Российский кардиологический журнал. 2020;25(3):3801 [Shlyakhto EV, Konradi A O, Arutyunov GP, et al. Guidelines for the diagnosis and treatment of circulatory diseases in the context of the COVID-19 pandemic. Russian Journal of Cardiology. 2020;25(3):3801 (In Russ.)]. doi: 10.15829/1560-4071-2020-3-3801
- Massachusetts General Hospital COVID-19. Treatment Guidance Version 1.36, 4/5/2020 5:00PM. The General Hospital Corporation. All Rights Reserved. https://medach.pro/post/2322
- The Liverpool Drug Interaction Group. https://www.covid19-druginteractions.org/
- Tisdale JE. Drug-induced QT interval prolongation and torsades de pointes: Role of the pharmacist in risk assessment, prevention and management. Can Pharm J (Ott). 2016 May;149(3):139-52. doi: 10.1177/1715163516641136
- Lane JCE, Weaver J, et al. Safety of hydroxychloroquine, alone and in combination with azithromycin, in light of rapid wide-spread use for COVID-19: a multinational, network cohort and self-controlled case series study. doi: 10.1101/2020.04.08.20054551
- Ventricular Arrhythmia Risk Due to Hydroxychloroquine-Azithromycin Treatment For COVID-19 Mar 29, 2020. https://www.acc.org/latest-in-cardiology/articles/2020/03/27/14/00/ventricular-arrhythmia-risk-due-to-hydroxychloroquine-azithromycin-treatment-for-covid-19
- Vaduganathan M, Vardeny O, Michel T, et al. Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19. March 30 2020. doi: 10.1056/NEJMsr2005760
- Kuba K, Imai Y, Rao S, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 2005;11(8):875-9. doi: 10.1038 / nm1267
- Mitchel L. Zoler Evidence Suggests Possible RAS-Blocker Benefit in Patients With COVID-19 Medscape Medical News. April 17 2020. https://www.medscape.com/viewarticle/928902?src=soc_fb_share
- Henry C, Zaizafoun M, Stock E, et al. Impact of angiotensin-converting enzyme inhibitors and statins on viral pneumonia. Proc (Bayl Univ Med Cent). 2018;31(4):419-23. doi: 10.1080/08998280.2018.1499293
- Liu Y, Huang F, Xu J, et al. Anti-hypertensive Angiotensin II receptor blockers associated to mitigation of disease severity in elderly COVID-19 patients. medRxiv preprint. doi: 10.1101/2020.03.20.20039586
- 03.2020 HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19 – American College of Cardiology. https://www.acc.org/latest-in-cardiology/articles/2020/03/17/08/59/hfsa-acc-aha-statement-addresses-concerns-re-using-raas-antagonists-in-covid-19
- Position Statement of the ESC Council on Hypertension on ACE-Inhibitors and Angiotensin Receptor Blockers 13 Mar 2020. https://www.escardio.org/Councils/Council-on-Hypertension-(CHT)/News/position-statement-of-the-esc-council-on-hypertension-on-ace-inhibitors-and-ang
- Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? March 11, 2020. doi: 10.1016/S2213-2600(20)30116-8
- Fedson DS. Treating influenza with statins and other immunomodulatory agents. Antiviral Res 2013;99:417-35. doi: 10.1016/j.antiviral.2013.06.018
- Zheng Y, Ma Y, Zhang J, et al. COVID-19 and the cardiovascular system. Nat Rev Cardiol 2020. doi: 10.1038/s41569-020-0360-5
- Zhou M, Zhang X, Qu J. Coronavirus disease 2019 (COVID-19): a clinical update. Front Med. 2020 Apr 2. doi: 10.1007/s11684-020-0767-8
- Danzi G, Loffi M, Galeazzi G, Gherbesi E. Acute pulmonary embolism and COVID-19 pneumonia: a random association? Eur Heart J. 2020;ehaa254. doi: 10.1093/eurheartj/ehaa254
- Jecko Thachil, Ning Tang, Satoshi Gando et al. ISTH interim guidance on recognition and management of coagulopathy in COVID-19. https://onlinelibrary.wiley.com/doi/epdf/10.1111/jth.14810
- Hunt B, Retter A, McClintock C. Practical guidance for the prevention of thrombosis and management of coagulopathy and disseminated intravascular coagulation of patients infected with COVID-19. 25th March 2020. https://thrombosisuk.org/downloads/T&H%20and%20COVID.pdf
- World Health Organization. Cardiovascular diseases (CVDs) Fact sheet No 317. Internet. 2015 Jan. http://www.who.int/mediacentre/factsheets/fs317/en//
- Tancredi M, Rosengren A, Svensson AM, et al. Excess Mortality among Persons with Type 2 Diabetes. N Engl J Med. 2015;373:1720-32. doi: 10.1056/NEJMoa1504347
- Yang JK, Feng Y, Yuan MY, et al. Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS. Diabet Med 2006;23(6):623e8. doi: 10.1111/j.1464-5491.2006.01861.x
- Allard R, Leclerc P, Tremblay C, Tannenbaum TN. Diabetes and the severity of pandemic influenza A (H1N1) infection. Diabetes Care. 2010;33(7):1491e3. doi: 10.2337/dc09-2215
- Al-Tawfiq JA, Hinedi K, Ghandour J, et al. Middle East respiratory syndrome coronavirus: a case control study of hospitalized patients. Clin Infect Dis. 2014;59:160e5. doi: 10.1093/cid/ciu226.
- Alraddadi BM, Watson JT, Almarashi A, et al. Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans. Saudi Arabia 2014. Emerg Infect Dis 2016;22:49e55. doi: 10.3201/eid2201.151340
- Fadini GP, Morieri ML, Longato E, Avogaro A. Prevalence and impact of diabetes among people infected with SARS-CoV-2. J Endocrinol Invest. 2020 Mar 28. doi: 10.1007/s40618-020-01236-2
- Preliminary estimates of the prevalence of selected underlying health conditions among patients with coronavirus disease 2019 d United States, February 12 – March 28, 2020. CDC COVID-19 response team. https://www.cdc.gov/mmwr/volumes/69/wr/mm6913e2.htm
- Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497e506. doi: 10.1016/S0140-6736(20)30183-5
- Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronaviruse infected pneumonia in wuhan, China. J Am Med Assoc. 2020;323(11):1061e9. doi: 10.1001/jama.2020.1585
- Zhang JJ, Dong X, Cao YY et al. Clinical characteristics of 140 patients infected with SARSCoV-2 in Wuhan, China. Allergy. 2020 Feb 19. doi: 10.1111/all.14238
- Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in wuhan, China. JAMA Intern Med. 2020 March 13. doi: 10.1001/jamainternmed.2020.0994
- Garg S, Kim L, Whitaker M, et al. Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 – COVID-NET, 14 States, March 1-30, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(15):458-64. doi: 10.15585/mmwr.mm6915e3
- Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. March 2020;9. doi: 10.1016/S0140-6736(20)30566-3
- Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese center for disease control and prevention. J Am Med Assoc. 2020 Feb 24. doi: 10.1001/jama.2020.2648
- Yang JK, Lin SS, Ji XJ, Guo LM. Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta Diabetol. 2010;47(3):193e9. doi: 10.1007/s00592-009-0109-4
- Liu W, Li H. COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism. ChemRxiv. Preprint. 2020. doi: 10.26434/chemrxiv.11938173.v7
- Pal R, Bhadada SK. Should anti-diabetic medications be reconsidered amid COVID-19 pandemic? Diabetes Res Clin Pract. 2020;108146. doi: 10.1016/j.diabres.2020.108146
- Knapp S. Diabetes and infection: is there a link? – A minireview clinical section/mini-review. Gerontology. 2013;59:99-104. doi: 10.1159/000345107
- Badawi A, Ryoo SG. Prevalence of diabetes in the 2009 influenza A (H1N1) and the Middle East respiratory syndrome coronavirus: a systematic review and meta-analysis. J Public Health Res. 2016;5(3):733. doi: 10.4081/jphr.2016.733
- Ma WX, Ran XW. The Management of Blood Glucose Should be Emphasized in the Treatment of COVID-19. Sichuan Da Xue Xue Bao Yi Xue Ban. 2020;51(2):146-50. doi: 10.12182/20200360606
- Yao RQ, Ren C, Wu GS, et al. Is intensive glucose control bad for critically ill patients? A systematic review and meta-analysis. Int J Biol Sci. 2020;16(9):1658-75. doi: 10.7150/ijbs.43447
- Available from: http://www.almazovcentre.ru/?p=62944
- Moghissi ES, Korytkowski MT, DiNardo M, et al. American Association of Clinical Endocrinologists. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Diabetes Care. 2009;32:1119-31. doi: 10.4158/EP09102.RA
- Zelniker TA, Wiviott SD, Raz I, et al. SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials. Lancet. 2019;393(10166):31-9. doi: 10.1016/S0140-6736(18)32590-X
- Hallow KM, Greasley PJ, Helmlinger G, et al. Evaluation of renal and cardiovascular protection mechanisms of SGLT2 inhibitors: model-based analysis of clinical data. Am J Physiol Renal Physiol. 2018;315(5):F1295-F1306. doi: 10.1152/ajprenal.00202.2018
- Fralick M, Schneeweiss S, Patorno E. Risk of Diabetic Ketoacidosis after Initiation of an SGLT2 Inhibitor. N Engl J Med. 2017;376(23):2300-02. doi: 10.1056/NEJMc1701990
- Cahn A, Mosenzon O, Wiviott SD, et al. Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study. Diabetes Care. 2020;43(2):468-75. doi: 10.2337/dc19-1476
- Bethel MA, Patel RA, Merrill P, et al. Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis. Lancet Diabetes Endocrinol. 2018;6(2):105-13. doi: 10.1016/S2213-8587(17)30412-6
- Nassif ME, Kosiborod M. A Review of Cardiovascular Outcomes Trials of Glucose-Lowering Therapies and Their Effects on Heart Failure Outcomes. Am J Cardiol. 2019;124(Suppl. 1):S12-S19. doi: 10.1016/j.amjcard.2019.10.025
- Romaní-Perez M, Outeirino-Iglesias V, Moya CM, et al. Activation of the GLP-1 receptor by liraglutide increases ACE2 expression, reversing right ventricle hypertrophy, and improving the production of SP-A and SP-B in the lungs of type 1 diabetes rats. Endocrinology. 2015;156(10):3559e69. doi: 10.1210/en.2014-1685
- Marso SP, Daniels GH, Brown-Frandsen K, et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2016;375(4):311-22. doi: 10.1056/NEJMoa1603827
- Muniyappa R, Gubbi S. COVID-19 Pandemic, Corona Viruses, and Diabetes Mellitus. Am J Physiol Endocrinol Metab. 2020 Mar 31. doi: 10.1152/ajpendo.00124.2020
- Eurich DT, Weir DL, Majumdar SR, et al. Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: systematic review of observational studies involving 34,000 patients. Circ Heart Fail. 2013;6(3):395-402. doi: 10.1161/CIRCHEARTFAILURE.112.000162
- Available from: https://webinar-endo.ru/archive/08042020koronavirusnaya-infekciya-covid-19-i-saharnyy-diabet-chto-izvestno-na-segodnyashniy
- Salpeter SR, Greyber E, Pasternak GA, Salpeter EE. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev. 2010;2010(4):CD002967. doi: 10.1002/14651858.CD002967.pub4
- Seferović PM, Petrie MC, Filippatos GS, et al. Type 2 diabetes mellitus and heart failure: a position statement from the Heart FailureAssociation of the European Society of Cardiology. Eur J Heart Fail. 2018;20(5):853-72. doi: 10.1002/ejhf.1170
- Verma S, Goldenberg R, Bhatt D, et al. Dipeptidyl peptidase-4 inhibitors and the risk of heart failure: a systematic review and meta-analysis. CMAJ Open. 2017;5(1):E152-E177. doi: 10.9778/cmajo.20160058
- Iacobellis G. COVID-19 and Diabetes: can DPP4 inhibition play a role? Diabetes Res Clin Pract. 2020;162:108125. doi: 10.1016/ j.diabres.2020.108125
- Gorricho J, Garjon J, Alonso A, et al. Use of oral antidiabetic agents and risk of community-acquired pneumonia: a nested case-control study. Br J Clin Pharmacol. 2017;83(9):2034e44. doi: 10.1111/bcp.13288
- Alraddadi BM, Watson JT, Almarashi A, et al. Risk factors for primary Middle East respiratory syndrome coronavirus illnessin humans. Saudi Arabia 2014. Emerg Infect Dis 2016;22:49e55. doi: 10.3201/eid2201.151340
- Zhou D, Dai S-M, Tong Q. COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression. J Antimicrob Chemother [Internet]. 2020 Mar 25. https://academic. oup.com/jac/advance-article/doi/10.1093/jac/dkaa114/5810487
- Brufsky A. Hyperglycemia, Hydroxychloroquine, and the COVID-19 Epidemic. J Med Virol. 2020 Apr 15. doi: 10.1002/jmv.2588
- Jin-Jin Zhang, Xiang Dong, Yi-Yuan Cao, et al. Clinical Characteristics of 140 Patients Infected With SARS-CoV-2 in Wuhan, China. 2020 Feb 19. doi: 10.1111/all.14238
- Guan WJ, Ni ZY, Hu Y, et al., for the China Medical Treatment Expert Group for Covid-19. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020. doi: 10.1056/NEJMoa2002032
- Xiaochen Li, Shuyun Xu, Muqing Yu, et al. Risk factors for severity and mortality in adult COVID-19 in patients in Wuhan. Journal of Allergy and Clinical Immunology. 2020 Apr 9. doi: 10.1016/j.jaci.2020.04.006
- Yang Jing, Ya Zheng, Xi Gou, et al. Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis. Int J Infect Dis. 2020 Mar 12. doi: 10.1016/j.ijid.2020.03.017
- Vardava CI, Nikitara K. COVID-19 and smoking: A systematic review of the evidence Tob Induc Dis. 2020;18:20. doi: 10.18332/tid/119324
- Global initiative for asthma (GINA) 2020. https://ginasthma.org/ gina-reports/
- Global initiative on chronic obstructive pulmonary disease (GOLD) 2020. https://goldcopd.org/gold-covid-19-guidance/
- Naicker S, Yang CW, Hwang SJ, et al. The Novel Coronavirus 2019 Epidemic and Kidneys. Kidney Int. 2020. doi: 10.1016/j.kint.2020.03.001
- Pan X-W, Xu D, Zhang H, et al. Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis. Intensive Care Med. 2020. 17.04.2020. doi: 10.1007/s00134-020-06026-1
- Yao X, Li T, He Z, et al. Histopathological study on multiple sites of puncture of the remains of 3 cases of novel coronavirus pneumonia (COVID-19). Chin J Pathol. 2020;49. doi: 10.3760/cma.j.cn112151-20200312-00193
- Huang C, Wang Y, Li X, et al. Clinical Features of Patients Infected With 2019 Novel Coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5
- Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;201585. doi: 10.1001/jama.2020.1585
- Yang X, Yu Y, Xu J, et al. Clinical Course and Outcomes of Critically Ill Patients With SARS-CoV-2 Pneumonia in Wuhan, China: A Single-Centered, Retrospective, Observational Study. Lancet Respir Med. 2020. doi: 10.1016/S2213-2600(20)30079-5
- Deng Y, Liu W, Liu K, et al. Clinical Characteristics of Fatal and Recovered Cases of Coronavirus Disease 2019 (COVID-19) in Wuhan, China: A Retrospective Study. Chin Med J (Engl). 2020. doi: 10.1097/CM9.0000000000000824
- Cheng Y, Luo R, Wang K, et al. Kidney Disease Is Associated With In-Hospital Death of Patients With COVID-19. Kidney Int. 2020;S0085-2538(20):30255-6. doi: 10.1016/j.kint.2020.03.005
- Ma Y, Diao B, Lv X, et al. 2019 novel coronavirus disease in hemodialysis (HD) patients: report from one HD center in Wuhan, China. Blog – NephJC. 2020. doi: 10.1101/2020.02.24.20027201
- Информация по коронавирусной инфекции COVID-19. Ассоциация Нефрологов. 17.04.2020 [Information on COVID-19 coronavirus infection. Association of Nephrologists. 17.04.2020 (In Russ.)]. http://www.rusnephrology.org/professional/
- Izzedine H, Jhaveri KD, Perazella MA. COVID-19 therapeutic options for patients with kidney disease. Kidney Int. 2020. doi: 10.1016/j.kint.2020.03.015
- Available from: https://www.era-edta.org/en/covid-19-newsand-information/#toggle-id-23
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