Modulation of cardiac contractility in patients with chronic heart failure and atrial fibrillation

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Abstract

Aim. to evaluate the effectiveness of cardiac contractility modulation (MSS) in patients with chronic heart failure (CHF) and atrial fibrillation (AF).

Materials and methods. The following studies were performed in 40 patients with CHF and AF before implantation of the MSS device and after 2 and 6 months of follow-up: 12-channel ECG, transthoracic EchoCG, 6-minute walk test, determination of the level of Pro-natriuretic N-terminal peptide (NT-proBNP), daily ECG monitoring, and a questionnaire based on the Minnesota quality of life questionnaire for patients with CHF (MHFLQ). All patients received long-term optimal drug therapy for CHF before surgery.

Results. The results obtained indicate a statistically significant positive effect of the use of MSS in patients with CHF and AF on LV FV, the functional class of CHF, and levels of NT-proBNP regardless of the etiology of CHF.

Conclusion. The use of MSS may be promising for the treatment of heart failure in patients with CHF and AF.

About the authors

T. M. Uskach

National Medical Research Center for Cardiology; Russian Medical Academy of Continuous Professional Education

Email: a_safiulina@mail.ru
ORCID iD: 0000-0003-4318-0315

д.м.н., в.н.с. отд. заболеваний миокарда и сердечной недостаточности ФГБУ «НМИЦ кардиологии», проф. каф. кардиологии ФГБУ ДПО РМАНПО

Russian Federation, Moscow

A. A. Safiullina

National Medical Research Center for Cardiology

Author for correspondence.
Email: a_safiulina@mail.ru
ORCID iD: 0000-0003-3483-4698

к.м.н., н.с. отд. заболеваний миокарда и сердечной недостаточности ФГБУ «НМИЦ кардиологии»

Russian Federation, Moscow

O. V. Sapel’nikov

National Medical Research Center for Cardiology

Email: a_safiulina@mail.ru
ORCID iD: 0000-0002-5186-2474

д.м.н., рук. лаб. хирургических и рентгенхирургических методов лечения нарушений ритма сердца отд. сердечно-сосудистой хирургии ФГБУ «НМИЦ кардиологии»

Russian Federation, Moscow

V. A. Amanatova

National Medical Research Center for Cardiology

Email: a_safiulina@mail.ru
ORCID iD: 0000-0002-0678-9538

ординатор отд. заболеваний миокарда и сердечной недостаточности ФГБУ «НМИЦ кардиологии»

Russian Federation, Moscow

O. A. Nikolaeva

Davydovsky Сity Clinical Hospital

Email: a_safiulina@mail.ru
ORCID iD: 0000-0001-6833-8938

к.м.н, врач терапевт/кардиолог, ГБУЗ «ГКБ №23 им. И.В. Давыдовского», центр персонализированной медицины

Russian Federation, Moscow

I. R. Grishin

National Medical Research Center for Cardiology

Email: a_safiulina@mail.ru
ORCID iD: 0000-0002-2689-2751

к.м.н., сердечно-сосудистый хирург отд. сердечно-сосудистой хирургии ФГБУ «НМИЦ кардиологии»

Russian Federation, Moscow

B. M. Nazarov

City Polyclinic №191

Email: a_safiulina@mail.ru
ORCID iD: 0000-0003-2145-1284

к.м.н., врач-кардиолог, зав. филиалом №3 ГБУЗ ГП №191

Russian Federation, Moscow

S. N. Tereshchenko

National Medical Research Center for Cardiology; Russian Medical Academy of Continuous Professional Education

Email: a_safiulina@mail.ru
ORCID iD: 0000-0001-9234-6129

д.м.н., проф., рук. отд. заболеваний миокарда и сердечной недостаточности ФГБУ «НМИЦ кардиологии», зав. каф. кардиологии ФГБУ ДПО РМАНПО

Russian Federation, Moscow

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