Mental disorders and cognitive impairment in patients with antiphospholipid syndrome
- Authors: Borisova A.B.1, Lisitsyna T.A.2, Veltishchev D.Y.1,3, Reshetnyak T.M.2,4, Seravina O.F.1, Kovalevskaya O.B.1, Krasnov V.N.1,3, Nasonov E.L.2
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Affiliations:
- Moscow Research Institute of Psychiatry – branch of Serbskiy National Medical Research Center for Psychiatry and Addiction
- Nasonova Research Institute of Rheumatology
- Pirogov Russian National Research Medical University
- Russian Medical Academy of Continuous Professional Education
- Issue: Vol 92, No 5 (2020)
- Pages: 92-103
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/34590
- DOI: https://doi.org/10.26442/00403660.2020.05.000625
- ID: 34590
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Abstract
Mental disorders (mainly anxiety and depressive disorders) and cognitive impairment are often found in patients with antiphospholipid syndrome (APS), but their prevalence, structure, and mechanisms of occurrence are not well researched. The review provides literature data on the frequency, spectrum and possible causes of mental disorders and cognitive impairment in patients with APS, the pathogenetic mechanisms of these disorders (in particular, the important role of antiphospholipid antibodies, stress factors, chronic inflammation), the relationship between APS, mental disorders and as well as cognitive impairment is examined. Special attention is paid to the influence of mental disorders and cognitive impairment on patients’ adherence to treatment, their quality of life, as well as the particularities of psychopharmacotherapy of mental disorders in patients with APS. The aim of the review is to actualize the interdisciplinary problem of mental disorders and cognitive impairment in patients with APS and the need to introduce a partnership model of care.
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##article.viewOnOriginalSite##About the authors
A. B. Borisova
Moscow Research Institute of Psychiatry – branch of Serbskiy National Medical Research Center for Psychiatry and Addiction
Author for correspondence.
Email: desolatorius@yandex.ru
ORCID iD: 0000-0001-6802-0268
мл. науч. сотр. отд-ния психических расстройств при соматических заболеваниях
Russian Federation, MoscowT. A. Lisitsyna
Nasonova Research Institute of Rheumatology
Email: desolatorius@yandex.ru
ORCID iD: 0000-0001-9437-406X
д.м.н., вед. науч. сотр. лаб. сосудистой ревматологии
Russian Federation, MoscowD. Yu. Veltishchev
Moscow Research Institute of Psychiatry – branch of Serbskiy National Medical Research Center for Psychiatry and Addiction; Pirogov Russian National Research Medical University
Email: desolatorius@yandex.ru
д.м.н., проф. каф. психиатрии
T. M. Reshetnyak
Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuous Professional Education
Email: desolatorius@yandex.ru
ResearcherId: T-9886-2018
д.м.н., проф. каф. ревматологии; рук. лаб. сосудистой ревматологии
O. F. Seravina
Moscow Research Institute of Psychiatry – branch of Serbskiy National Medical Research Center for Psychiatry and Addiction
Email: desolatorius@yandex.ru
науч. сотр. отд-ния психических расстройств при соматических заболеваниях
Russian Federation, MoscowO. B. Kovalevskaya
Moscow Research Institute of Psychiatry – branch of Serbskiy National Medical Research Center for Psychiatry and Addiction
Email: desolatorius@yandex.ru
науч. сотр. отд-ния психических расстройств при соматических заболеваниях
Russian Federation, MoscowV. N. Krasnov
Moscow Research Institute of Psychiatry – branch of Serbskiy National Medical Research Center for Psychiatry and Addiction; Pirogov Russian National Research Medical University
Email: desolatorius@yandex.ru
ResearcherId: A-5117-2013
рук. отд.; зав. каф. психиатрии
Russian Federation, MoscowE. L. Nasonov
Nasonova Research Institute of Rheumatology
Email: desolatorius@yandex.ru
науч. рук.
Russian Federation, MoscowReferences
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