Idiopathic multicentric Castleman’s disease

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Abstract

Idiopathic multicentric Castleman’s disease is a rare lymphoproliferative disorder that has many similar laboratory, radiological, clinical and pathological manifestations with various conditions, including IgG4-related disease. Increased activity of cytokines, especially interleukin-6, leads to systemic inflammatory symptoms with the development of lymphadenopathy and rarely extranodal lesions. Histological changes in the lymph nodesin hyaline vascular and plasma cell variants of Castleman’s disease are hardly distinguishable from the pattern of reactive, tumor and IgG4-related lymphadenopathy. Idiopathic multicentric Castleman’s disease can be diagnosed only when infection with human herpesvirus-8 type and human immunodeficiency virus is excluded. In the article, the authors describe two cases of idiopathic multicentric Castleman’s disease, including the first world literature description of extranodal damage of the hip muscle in this disorder. In addition, the authors gave a review of the literature on the main clinical, laboratory and morphological manifestations, which allow confirming the diagnosis of Castleman’s disease.

About the authors

V. I. Vasilyev

Nasonova Research Institute of Rheumatology

Email: bodya92@inbox.ru
ORCID iD: 0000-0003-4350-1166

 д.м.н., проф., вед. науч. сотр. лаб. интенсивных методов терапии ревматических заболеваний

Russian Federation, Moscow

S. G. Palshina

Nasonova Research Institute of Rheumatology

Email: bodya92@inbox.ru
ORCID iD: 0000-0003-3389-7064

к.м.н., мл. науч. сотр. лаб. интенсивных методов терапии ревматических заболеваний

Russian Federation, Moscow

A. I. Pavlovskaya

Blokhin National Medical Research Center of Oncology

Email: bodya92@inbox.ru

к.м.н., вед. науч. сотр. отд. патологической анатомии опухолей человека

Russian Federation, Moscow

N. V. Kokosadze

Blokhin National Medical Research Center of Oncology

Email: bodya92@inbox.ru

к.м.н., ст. науч. сотр. отд. патологической анатомии опухолей человека

Russian Federation, Moscow

B. D. Chaltsev

Nasonova Research Institute of Rheumatology

Author for correspondence.
Email: bodya92@inbox.ru
ORCID iD: 0000-0003-4188-3578

мл. науч. сотр. лаб. интенсивных методов терапии ревматических заболеваний

Russian Federation, Moscow

L. A. Shornikova

Yevdokimov Moscow State University of Medicine and Dentistry

Email: bodya92@inbox.ru
ORCID iD: 0000-0002-2607-6041

студентка лечебного фак-та

Russian Federation, Moscow

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