Rebamipide using in gastroesophageal reflux disease treatment

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Abstract

Rebamipide is a mucoprotective drug which was developed in Japan in 1990. The therapeutic effect of rebamipide based on the induction of cyclooxygenase-2 and increasing level of prostaglandins, inhibition of oxygen free radicals production, epidermal growth factor stimulation, vascular endothelial growth factor, nitric oxide, and decreasing of lipid peroxidation and neutrophils migration. The combination of proton pump inhibitors and rebamipide is more effective in relieving of gastroesophageal reflux disease symptoms and reducing recurrence rate of disease. Using rebamipide in the treatment of gastroesophageal reflux disease is justified because this drug has a unique mechanism of action, which eliminating the main stages of pathogenesis of the disease.

About the authors

V. T. Ivashkin

Sechenov First Moscow State Medical University (Sechenov University)

Email: maximgonik@gmail.com
ORCID iD: 0000-0002-6815-6015

акад. РАН, д.м.н., проф., зав. каф. пропедевтики внутренних болезней, гастроэнтерологии, гепатологии

Russian Federation, Moscow

A. S. Trukhmanov

Sechenov First Moscow State Medical University (Sechenov University)

Email: maximgonik@gmail.com
ORCID iD: 0000-0003-3362-2968

д.м.н., проф. каф. пропедевтики внутренних болезней, гастроэнтерологии, гепатологии

Russian Federation, Moscow

M. I. Gonik

Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: maximgonik@gmail.com
ORCID iD: 0000-0002-0605-8057

клинический ординатор каф. пропедевтики внутренних болезней, гастроэнтерологии, гепатологии

Russian Federation, Moscow

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Supplementary files

Supplementary Files
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2. Fig. 1. Levels of cytoprotection of the esophagus [8].

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3. Fig. 2. Features of intercellular compounds in different types of epithelium [3].

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4. Fig. 3. Correlation of IL-8 expression and the degree of esophagitis in GERD [4].

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5. Fig. 4. Dependence of the reduction of NPS pressure on the GHG dose in possums [12].

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6. Fig. 5. Scheme of the pathological process of acid-dependent diseases of the esophagus with the participation of oxygen free radicals [8].

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7. Fig. 6. Change in the level of expression of tight contact proteins during modeling of GERD in rats [21].

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8. Fig. 7. Change in the expression level of microbiota in rats in the rebamipid and control group [22].

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9. Fig. 8. Change in the symptoms of reflux esophagitis in 501 patients in the monotherapy group with esomeprazole and in the combination group of rebamipid and esomeprazole [24].

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