Features of the course of gallstone disease in patients with non-alcoholic fatty liver disease

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Abstract

Aim. To update information about comorbidity of non-alcoholic fatty liver disease (NAFLD) and gallstones disease (GD), evaluation of clinical and laboratory data, including insulin, leptin and adiponectin in individuals with NAFLD in combination with GD.

Materials and methods. According to the design, we conducted an open comparative study of 169 patients with NAFLD. The following comparison groups were formed: group 1 (n=95) – patients with NAFLD without GD, group 2 (n=35) – patients with NAFLD and GD and group 3 (n=39) – patients with NAFLD, GD and previous cholecystectomy.

Results. A high prevalence of coronary heart disease was found in the group of patients with GD and cholecystectomy (χ2=6.198, p≤0.05); positive, statistically significant correlation relationships of cholelithiasis, cholecystectomy with ischemic heart disease (rs=0.172, p≤0.05 and rs=0.241, p≤0.05, respectively). There was a statistically significant decrease in total bilirubin and total protein in patients of group 3 (H=7.376, p≤0.03 and H=6.345, p≤0.04). The level of leptin is statistically significantly higher and positively interrelated with cholecystectomy (H=5.812, p≤0.05, rs=0.313, p≤0.05).

Conclusion. Patients with NAFLD, GD and previous cholecystectomy have a high prevalence of coronary heart disease; the phenomenon of insulin and leptin resistance, high level of adiponectin were revealed in patients with NAFLD and gallstones; hyperleptinemia was observed among patients with NAFLD, GD after cholecystectomy.

About the authors

N. A. Cherkashchenko

West-Siberian Medical Center

Email: mts-8-90@mail.ru
ORCID iD: 0000-0003-3743-143X

зав. терапевтическим отд-нием, врач-гастроэнтеролог, терапевт

Russian Federation, Omsk

M. A. Livzan

Omsk State Medical University

Email: mts-8-90@mail.ru
ORCID iD: 0000-0002-6581-7017
Scopus Author ID: 24341682600

д.м.н., проф., зав. каф. факультетской терапии, профессиональных болезней, ректор

Russian Federation, Omsk

T. S. Krolevets

Omsk State Medical University

Author for correspondence.
Email: mts-8-90@mail.ru
ORCID iD: 0000-0002-7452-7230
Scopus Author ID: 56848263100

д.м.н., проф., зав. каф. факультетской терапии, профессиональных болезней, ректор

Russian Federation, Omsk

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