The clinical status and treatment options for osteoarthritis in patients with frailty


Cite item

Full Text

Abstract

Aging is an independent risk factor for the development of many diseases and geriatric syndromes. Osteoarthritis (OA), as the most common joint disease in the elderly, can be attributed to age - associated conditions. And the most significant geriatric syndrome, which dramatically affects the management and prognosis of an elderly, is frailty. The review provides current information on the prevalence of OA and frailty, their clinical and prognostic significance, and also shows the mutually aggravating role of these two conditions. The difference between non - and medication management of patients with OA and frailty is emphasized.

About the authors

A V Naumov

Pirogov Russian National Research Medical University

Moscow, Russia

N O Khovasova

Pirogov Russian National Research Medical University

Moscow, Russia

V I Moroz

Pirogov Russian National Research Medical University

Moscow, Russia

O N Tkacheva

Pirogov Russian National Research Medical University

Moscow, Russia

O A Shavlovskaya

Sechenov First Moscow State Medical University (Sechenov University)

Moscow, Russia

References

  1. Lawrence R.C, Felson D.T, Helmick C.G, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II. Arthritis Rheum. 2008;58(1):26-35.
  2. Murphy L, Schwartz T.A, Helmick C.G, et al. Lifetime risk of symptomatic knee osteoarthritis. Arthritis Rheum. 2008;59(9):1207-13. doi: 10.1002/art.24021
  3. Lawrence J.S, Bremner J.M, Bier F. Osteoarthrosis. Prevalence in the population and relationship between symptoms and X-ray changes. Ann Rheum Dis. 1966;25(1):1-24. doi: 10.1136/annrheumd00506-0006
  4. Miller M.E, Rejeski W.J, Messier S.P, et al. Modifiers of change in physical functioning in older adults with knee pain: the Observational Arthritis Study in Seniors (OASIS). Arthritis Rheum. 2001;45(4):331-9. doi: 10.1002/1529-0131(200108)45:4<331::aid-art345>3.0.co;2-6
  5. Felson D.T, Naimark A, Anderson J, et al. The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 1987;30(8):914-8. doi: 10.1002/art.1780300811
  6. Jordan J.M, Helmick C.G, Renner J.B, Luta J, Dragomir A.D, Woodard J, Fang F, Schwartz T.A, Nelson A.E, Abbate L.M, Callahan L.F. Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project. J Rheumatol. 2009;36(4):809-15. doi: 10.3899/jrheum.080677
  7. Felson D.T. Risk factors for osteoarthritis: understanding joint vulnerability. Clin Orthopaed Relat Res. 2004;(427 Suppl):S16-21. doi: 10.1097/01.blo.0000144971.12731.a2
  8. Chaganti R.K, Parimi N, Cawthon P, Dam T.L, Nevitt M.C, Lane N.E. Association of 25-hydroxyvitamin D with prevalent osteoarthritis of the hip in elderly men: the osteoporotic fractures in men study. Arthritis Rheum. 2010;62(2):511-4. doi: 10.1002/art.27241
  9. Gelber A.C. Joint injury in young adults and risk for subsequent knee and hip osteoarthritis. Ann Intern Med. 2000;133(5):321-8. doi: 10.7326/0003-4819-133-5-200009050-00007
  10. Roos H, Adalberth T, Dahlberg L, Lohmander L.S. Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age. Osteoarthritis Cartilage. 1995;3(4):261-7. doi: 10.1016/s1063-4584(05)80017-2
  11. Rosenthal A.K. Calcium crystal deposition and osteoarthritis. Rheum Dis Clin N Am. 2006;32(2):401-12. doi: 10.1016/j.rdc.2006.02.004
  12. Macfarlane G.J, Barnish M.S, Jones G.T. Persons with chronic wide - spread pain experience excess mortality: longitudinal results from UK Biobank and meta - analysis. Ann Rheum Dis. 2017;76:1815-22. doi: 10.1136/annrheumdis-2017-211476
  13. Sampson E.L, White N, Lord K, et al. Pain, agitation, and behavioural problems in people with dementia admitted to general hospital wards: a longitudinal cohort study. Pain. 2015;156:675-83. doi: 10.1097/j.pain.0000000000000095
  14. Rajkumar A.P, Ballard C, Fossey J, et al. Epidemiology of pain in people with dementia living in care homes: longitudinal course, prevalence, and treatment implications. J Am Med Direct Assoc. 2017;18:453.e1-e6. doi: 10.1016/j.jamda.2017.01.024
  15. Meraya A.M, Dwibedi N, Sambamoorthi U. Polypharmacy and Health-Related Quality of Life Among US Adults With Arthritis, Medical Expenditure Panel Survey, 2010-2012. Prevent Chron Dis. 2016;13:E132. doi: 10.5888/pcd13.160092
  16. Whitlock E.L, Diaz-Ramirez L.G, Glymour M.M, Boscardin W.J, Covinsky K.E, Smith A.K. Association between persistent pain and memory decline and dementia in a longitudinal cohort of elders. JAMA Intern Medic. 2017;177:1146-53. doi: 10.1001/jamainternmed.2017.1622
  17. Pitcher M.H, Von Korff M, Bushnell M.C, Porter L. Prevalence and Pro - file of High - Impact Chronic Pain in the United States. J Pain. 2018;20(2):146-60. doi: 10.1016/j.jpain.2018.07.006
  18. Walston J, Hadley E.C, Ferrucci L, Guralnik J.M, Newman A.B, Studenski S.A. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the american geriatrics society/national institute on aging research conference on frailty in older adults. J Am Geriatr Soc. 2006;54(6):991-1001. doi: 10.1111/j.1532-5415.2006.00745.x
  19. Клинические рекомендации Министерства здравоохранения Российской Федерации «Старческая астения». 2018;8-9.
  20. Rodríguez-Mañas L, Féart C, Mann G, Viña J, Chatterji S, Chodzko-Zajko W, Gonzalez-Colaço Harmand M, Bergman H, Carcaillon L, Nicholson C, Scuteri A, Sinclair A, Pelaez M, Van der Cammen T, Beland F, Bickenbach J, Delamarche P, Ferrucci L, Fried L.P, Gutiérrez-Robledo L.M, Rockwood K, Rodríguez Artalejo F, Serviddio G, Vega E. Searching for an operational definition of frailty: a Delphi method based consensus statement: the frailty operative definition - consensus conference project. J Gerontol: Ser A. 2013;68(1):62-7. doi: 10.1093/gerona/gls119
  21. Collard R.M, Boter H, Schoevers R.A, Oude Voshaar R.C. Prevalence of frailty in community - dwelling older persons: a systematic review. J Am Geriatr Soc. 2012.60(8):1487-92. doi: 10.1111/j.1532-5415.2012.04054.x
  22. American Medical Association white paper on elderly health. Report of the council on scientific affairs. Arch Intern Med. 1990;150(12):2459-72. doi: 10.1001/archinte.150.12.2459
  23. Murray C.J, Vos T, Lozano R, et al. Disability - adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2197-223. doi: 10.1016/S0140-6736(12)61689-4
  24. Misra D, Felson D.T, Silliman R.A, Nevitt M, Lewis C.E, Torner J, Neogi T. Knee osteoarthritis and frailty: findings from the Multicenter Osteoarthritis Study and Osteoarthritis Initiative. J Gerontol Ser A: Biol Sci Med Sci. 2015;70(3):339-44. doi: 10.1093/gerona/glu102
  25. Лучихина Л.В., Мендель О.И., Мендель В., Голухов Г.Н. Остеоартрит и возраст. Роль старения в этиологии и патогенезе заболевания. Современная ревматология. 2017;11(1):4-11 [. doi: 10.14412/1996-7012-2017-1-4-11
  26. Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, Panourgia M.P, Invidia L, Celani L, Scurti M, Cevenini E, Castellani G, Salvioli S. Inflammaging and anti - inflammaging: A systemic perspective on aging and longevity emerged from studies in humans. Mechan Ageing Devel. 2007;128(1):92-105. doi: 10.1016/j.mad.2006.11.016
  27. Ensrud K.E, Ewing S.K, Cawthon P.M, Fink H.A, Taylor B.C, Cauley J.A, Dam T-T, Marshall L.M, Orwoll E.S, Cummings S.R, for the Osteoporotic Fractures in Men Research Group. A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men. J Am Geriatr Soc. 2009;57:492-8. doi: 10.1111/j.1532-5415.2009.02137.x
  28. Felson D.T, Niu J, Yang T, Torner J, Lewis C.E, Aliabadi P, Sack B, Sharma L, Guermazi A, Goggins J, Nevitt M.C. Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI. Osteoarthritis Cartilage. 2013;21(6):789-95. doi: 10.1016/j.joca.2013.03.001
  29. Mc Guigan F.E, Bartosch P, Åkesson K.E. Musculoskeletal health and frailty. Best Pract Res Clin Rheumatol. 2017;31(2):145-59. doi: 10.1016/j.berh.2017.11.002
  30. Nakamura K.A. "Super - aged" society and the "locomotive syndrome". J Orthopaed Sci. 2008;13:1-2. doi: 10.1007/s00776-007-1202-6
  31. Ogata T, Muranaga S, Ishibashi H, Ohe T, Izumida R, Yoshimura N, et al. Development of a screening program to assess motor function in the adult population: a cross - sectional observational study. J Orthopaed Sci. 2015;20:888-985. doi: 10.1007/s00776-015-0737-1
  32. Yoshimura N, Oka H, Muraki S, Akune T, Hirabayashi N, Akune T, Matsuda S, Nojiri T, Hatanaka K, IshimotoYu, Nagata K, Yoshida M, Tokimura F, Kawaguchi H, Nakamura K. Reference values for hand grip strength, muscle mass, walking time, and one - leg standing time as indices for locomotive syndrome and associated disability: the second survey of the ROAD study. J Orthopaed Sci. 2011;16:768-77. doi: 10.1007/s00776-011-0160-1
  33. Kimura A, Seichi A, Konno S, Yabuki S, Hayashi K. Prevalence of locomotive syndrome in Japan: a nationwide, cross - sectional Internet survey. J Orthopaed Sci. 2014;19:792-7. doi: 10.1007/s00776-014-0606-3
  34. Yoshimura N, Muraki S, Nakamura K, Tanaka S. Epidemiology of the locomotive syndrome: The research on osteoarthritis/osteoporosis against disability study 2005-2015. Mod Rheumatol. 2017;27(1):1-7. doi: 10.1080/14397595.2016.1226471
  35. Ministry of Health, Labour, and Welfare. The outline of the results of National Livelihood Survey 2013. In: The Practitioner's Handbook to the Social Services. Elsevier, 2013. P. 70-6. doi: 10.1016/b978-1-4832-1368-2.50012-4
  36. Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T. Cohort profile: research on osteoarthritis/osteoporosis against disability study. Int J Epidemiol. 2010;39:988-95. doi: 10.1093/ije/dyp276
  37. Yoshimura N, Muraki S, Oka H, Mabuchi A, En-Yo Y, Yoshida M, Saika A, Yoshida H, Suzuki T, Yamamoto S, Ishibashi H, Kawaguchi H, Nakamura K, Akune T. Prevalence of knee osteoarthritis, lumbar spondylosis and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study. J Bone Mineral Metabol. 2009;27:620-8. doi: 10.1007/s00774-009-0080-8
  38. Locomotive Challenge Council. Locomotive syndrome. In: Locomotive Challenge Council, ed. Locomotive syndrome pamphlet 2013. Tokyo: Japanese Orthopaedic Association; 2013.
  39. Muramoto A, Imagama S, Ito Z, Hirano K, Ishiguro N, Hasegawa Y. Physical performance tests are useful for evaluating and monitoring the severity of locomotive syndrome. J Orthopaed Sci. 2012;17:782-8. doi: 10.1007/s00776-012-0283-z
  40. Bannuru R.R, Osani M.C, Vaysbrot E.E, Arden N.K, Bennell K, Bierma-Zeinstra S.M.A, Kraus V.B, Lohmander L.S, Abbott J.H, Bhandari M, Blanco F.J, Espinosa R, Haugen I.K, Lin J, Mandl L.A, Moilanen E, Nakamura N, Snyder-Mackler L, Trojian T, Underwood M, Mc Alindon T.E. OARSI guidelines for the non - surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019;27(11):1578-89. doi: 10.1016/j.joca.2019.06.011
  41. Guyatt G.H, Oxman A.D, Vist G.E, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schünemann H.J. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336:924-6. doi: 10.1136/bmj.39489.470347.ad
  42. Hochberg M.C. Serious joint - related adverse events in randomized controlled trials of antinerve growth factor monoclonal antibodies. Osteoarthritis Cartilage. 2015;23:18-21. doi: 10.1016/j.joca.2014.10.005
  43. Deveza L.A, Hunter D.J, Van Spil W.E. Too much opioid, too much harm. Osteoarthritis Cartilage. 2018;26:293-5. doi: 10.1016/j.joca.2017.12.003
  44. Jeffery M.M, Hooten W.M, Henk H.J, Bellolio M.F, Hess E.P, Meara E, Ross J, Shah N.D. Trends in opioid use in commercially insured and Medicare Advantage populations in 2007-16: retrospective cohort study. BMJ. 2018;362:2833. doi: 10.1136/bmj.k4825
  45. Inacio M.C.S, Cashman K, Pratt N.L, Gillam M.H, Caughey G, Graves S.E, Roughead E.E. Prevalence and changes in analgesic medication utilisation 1 year prior to total joint replacement in an older cohort of patients. Osteoarthritis Cartilage. 2018;26:356-62. doi: 10.1016/j.joca.2017.11.016
  46. Birke H, Kurita G.P, Sjøgren P, Højsted J, Simonsen M.K, Juel K, Ekholm O. Chronic non - cancer pain and the epidemic prescription of opioids in the Danish population: trends from 2000 to 2013. Acta Anaesthesiol Scand. 2016;60:623-33. doi: 10.1111/aas.12700
  47. Volkow N.D, Mc Lellan A.T. Opioid abuse in chronic pain - misconceptions and mitigation strategies. New Engl J Med. 2016;374:1253-63. doi: 10.1056/nejmra1507771
  48. Vowles K.E, Mc Entee M.L, Julnes P.S, Frohe T, Ney J.P, Van der Goes D.N. Rates of opioid misuse, abuse, and addiction in chronic pain: a systematic review and data synthesis. Pain. 2015;156:569-76. doi: 10.1097/01.j.pain.0000460357.01998.f1
  49. Da Costa B.R, Nüesch E, Kasteler R, Husni E, Welch V, Rutjes A.W, Jüni P. Oral or transdermal opioids for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2014. doi: 10.1002/14651858.cd003115.pub4
  50. Krebs E.E, Gravely A, Nugent S, Jensen A.C, DeRonne B, Goldsmith E.S, et al. Effect of opioid vs nonopioid medications on pain - related function in patients with chronic back pain or hip or knee osteoarthritis pain: the SPACE randomized clinical trial. JAMA. 2018;319:872-82. doi: 10.1001/jama.2018.0899
  51. Smith S.R, Deshpande B.R, Collins J.E, Katz J.N, Losina E. Comparative pain reduction of oral non - steroidal anti - inflammatory drugs and opioids for knee osteoarthritis: systematic analytic review. Osteoarthritis Cartilage. 2016;24:962-72. doi: 10.1016/j.joca.2015.02.655
  52. Алексеева Л.И., Таскина Е.А., Кашеварова Н.Г. Остеоартрит: эпидемиология, классификация, факторы риска и прогрессирования, клиника, диагностика, лечение. Современная ревматология. 2019;13(2):9-21. doi: 10.14412/1996-7012-2019-2-9-21
  53. Алексеева Л.И., Шарапова Е.П., Кашеварова Н.Г. и др. Сравнительное исследование эффективности и безопасности препарата Хондрогард® при комбинированном (внутрисуставное и внутримышечное) и внутримышечном введении у пациентов с остеоартритом коленных суставов. Современная ревматология. 2018;12(2):44-9. doi: 10.14412/1996-7012-2018-2-44-49
  54. Наумов А.В., Ткачева О.Н., Ховасова Н.О. Клинические возможности комплексного подхода в лечении рецидива хронической боли в коленных суставах у пациентов с коморбидными заболеваниями. РМЖ. 2019;1(II):1-2.
  55. Ballew S.H, Chen Y, Daya N.R, Godino J.G, Windham B.G, Mc Adams-De Marco M, Coresh J, Selvin E, Grams M.E. Frailty, kidney function, and polypharmacy: the atherosclerosis risk in communities (ARIC) study. Am J Kidney Dis. 2016;67:218-26. doi: 10.1053/j.ajkd.2016.08.034
  56. Vitale C, Spoletini I, Rosano G.M. Frailty in Heart Failure: Implications for Management. Card Failure Rev. 2018;4(2):104-6. doi: 10.15420/cfr.2018.22.2
  57. Conzade R, Grill-Heike E, Bischoff-Ferrari A, Ferrari U, Horsch A, Koenig W, Peters A, Thorand B. Vitamin D in Relation to Incident Sarcopenia and Changes in Muscle Parameters Among Older Adults: The KORA-Age Study. Calc Tis Intern. 2019;104(1):1-10. doi: 10.1007/s00223-019-00558-5
  58. Morante J.J.H, Martínez C.G, Morillas-Ruiz J.M. Dietary Factors Associated with Frailty in Old Adults: A Review of Nutritional Interventions to Prevent Frailty Development. Nutrients. 2019;11(1):102. doi: 10.3390/nu11010102
  59. Buta B, Choudhury P.P, Xue Q.L, et al. The Association of Vitamin D Deficiency and Incident Frailty in Older Women: The Role of Cardiometabolic Diseases. J Am Geriatr Soc. 2017;65(3):619-24. doi: 10.1111/jgs.14677
  60. Arokoski M.H, Arokoski J.P, Haara M, Kankaanpaa M, Vesterinen M, Niemitukia L.H. Hip muscle strength and muscle cross sectional area in men with and without hip osteoarthritis. J Rheumatol. 2002;29:2185-95.
  61. Toda Y, Segal N, Toda T, Kato A, Toda F. A decline in lower extremity lean body mass per body weight is characteristic of women with early phase osteoarthritis of the knee. J Rheumatol. 2000;27:2449-54.
  62. Zhai G, Blizzard L, Srikanth V, Ding C, Cooley H, Cicuttini F. Correlates of knee pain in older adults: Tasmanian older adult Cohort study. Arthritis Rheum. 2006;55:264-71. doi: 10.1002/art.21835
  63. O’Reilly S.C, Jones A, Muir K.R, Doherty M. Quadriceps weakness in knee osteoarthritis: the effect on pain and disability. Ann Rheum Dis. 1998;57:588-94. doi: 10.1136/ard.57.10.588
  64. Nevitt M.C, Cummings S.R, Kidd S, Black D. Risk factors for recurrent nonsyncopal falls: a prospective study. J Am Med Assoc. 1989;261:2663-8. doi: 10.1001/jama.261.18.2663
  65. Stabler T.V, Huang Z, Montell E, Vergés J, Kraus V.B. Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules. Osteoarthritis Cartilage. 2017;25(1):166-74. doi: 10.1016/j.joca.2016.08.012
  66. Ngoc Hoan Le, Chu-Sook Kim, Taesun Park, Jung Han Yoon Park, Mi-Kyung Sung, Dong Gun Lee, Sun-Myung Hong, Suck-Young Choe, Tsuyoshi Goto, Teruo Kawada, Rina Yu. Quercetin protects against obesity - induced skeletal muscle inflammation and atrophy. Mediat Inflamm. 2014;2014:1-10. doi: 10.1155/2014/834294
  67. Fioravanti A, Collodel G. In Vitro Effects of Chondroitin Sulfate. Advanc Pharmacol. 2006;53:449-65. doi: 10.1016/s1054-3589(05)53022-9
  68. Takeuchi S, Nakano S-I, Nakamura K, Ozoe A, Chien P, Yoshihara H, еt al. Roles of chondroitin sulfate proteoglycan 4 in fibrogenic/adipogenic differentiation in skeletal muscle tissues. Exper Cell Res. 2016;347(2):367-77. doi: 10.1016/j.yexcr.2016.08.023

Copyright (c) 2019 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies