Email this article Central hypothyroidism
- Authors: Petunina NA1, Trukhina LV1, Martirosian NS1
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Affiliations:
- Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 91, No 10 (2019)
- Pages: 135-138
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/33720
- DOI: https://doi.org/10.26442/00403660.2019.10.000358
- ID: 33720
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Abstract
Central hypothyroidism is a rare cause of hypothyroidism, consequence of various disorders affecting pituitary (secondary) or hypothalamus (tertiary hypothyroidism). Difficulties in the diagnosis and management of patients are due to the nontypical clinical picture, frequent combination with impaired function of other pituitary hormones, difficulties in laboratory assessment in high TSH levels or low - normal T4 free levels. Diagnosis is based on a confirmed decrease in the level of free T4 with a low or normal level of TSH. The standard treatment for hypothyroidism of any etiology remains monotherapy with levothyroxine, which allows to restore the euthyroid state in most patients. The criterion for the effectiveness of therapy is to maintain the level of T4 free in the upper half of the reference norm interval. The article presents a modern understanding of epidemiology, pathogenesis and strategies for managing patients with central hypothyroidism.
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##article.viewOnOriginalSite##About the authors
N A Petunina
Sechenov First Moscow State Medical University (Sechenov University)д.м.н., проф., зав. каф. эндокринологии лечебного факультета; ORCID: 0000-0001-9390-1200 Moscow, Russia
L V Trukhina
Sechenov First Moscow State Medical University (Sechenov University)к.м.н., доц. каф. эндокринологии лечебного факультета; ORCID: 0000-0001-8997-4984 Moscow, Russia
N S Martirosian
Sechenov First Moscow State Medical University (Sechenov University)
Email: narinarine@list.ru
к.м.н., ассистент каф. эндокринологии лечебного факультета; ORCID: 0000-0002-0202-1257 Moscow, Russia
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