Gastroesophageal reflux disease and esophagitis associated with the use of drugs: the modern state of the problem


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Abstract

From the standpoint of evidence - based medicine, the ability of various drugs to induce the development of gastroesophageal reflux disease and esophagitis is considered. Thus, all known drugs can be divided into 3 groups: drugs that have the ability to reduce pressure in the lower esophageal sphincter, for example, β-adrenoreceptor agonists, α-adrenoreceptor antagonists, anticholinergics, calcium channel blockers, nitrates, benzodiazepines (diazepam), estrogen, progesterone, aminophylline (theophylline), tricyclic antidepressants, selective serotonin reuptake inhibitors, glucocorticosteroids; means providing a direct damaging effect on the esophageal mucosa, as well as lowering its resistance reflyuktatu, e.g., bisphosphonates, acetylsalicylic acid / non - steroidal anti - inflammatory agents, anticoagulants, antiplatelet drugs, iron preparations, ascorbic acid, potassium chloride, quinidine, phenytoin, calcium dobesilate, 131I sodium iodide, antibiotics (tetracycline, doxycycline, clindamycin, ciprofloxacin, ornidazole, clindamycin, rifampicin), antitumor agents; drugs that impede gastric emptying: calcium channel blockers, anticholinergics. These data can be used in practice in the choice of treatment tactics, especially in individuals with a diagnosis of gastroesophageal reflux disease or heartburn.

About the authors

A M Osadchuk

Samara State Medical University

Email: maxlife2004@mail.ru
д.м.н., проф. каф. госпитальной терапии с курсами поликлинической терапии и трансфузиологии ФГБОУ ВО «СамГМУ»; тел.: +7(927)606-09-40; e-mail: maxlife2004@mail.ru; ORCID: 0000-0002-8488-9235 Samara, Russia

I L Davydkin

Samara State Medical University

д.м.н., проф., зав. каф. госпитальной терапии с курсами поликлинической терапии и трансфузиологии ФГБОУ ВО «СамГМУ»; ORCID: 0000-0003-0645-7645 Samara, Russia

T A Gricenko

Samara State Medical University

к.м.н., доц. каф. госпитальной терапии с курсами поликлинической терапии и трансфузиологии, врач-гематолог первого гематологического отделения клиник ФГБОУ ВО «СамГМУ»; ORCID: 0000-0002-2794-5122 Samara, Russia

M A Osadchuk

Sechenov First Moscow State Medical University (Sechenov University)

д.м.н., проф., зав. каф. поликлинической терапии лечебного факультета ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; ORCID: 0000-0003-0485-6802 Moscow, Russia

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