Sorafenib - induced thyroiditis in patient with a relapse of acute myelomonocytic leukemia with FLT3-ITD mutation


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Abstract

Sorafenib has been used in acute myeloid leukemias with FLT3-ITD mutation improving the outcomes. However the high incidence of treatment - emergent adverse event may be associated with treatment using sorafenib with cytotoxic chemotherapy. We have reported a case of severe thyroiditis in patient with a relapse of acute myelomonocytic leukemia.

About the authors

Ya B Balzhanova

National Research Center for Hematology

врач-гематолог отд-ния интенсивной высокодозной химиотерапии гематологических заболеваний с круглосуточным и дневным стационарами ФГБУ «НМИЦ гематологии»; ORCID: 0000-0001-8973-9407 Moscow, Russia

E N Parovichnikova

National Research Center for Hematology

д.м.н., врач-гематолог, зав. отд. химиотерапии гемобластозов, депрессий кроветворения и трансплантации костного мозга ФГБУ «НМИЦ гематологии»; ORCID: 0000-0001-6177-3566 Moscow, Russia

A N Sokolov

National Research Center for Hematology

к.м.н., врач-гематолог, с.н.с. отд-ния интенсивной высокодозной химиотерапии гемобластозов и депрессий кроветворения с круглосуточным и дневным стационарами ФГБУ «НМИЦ гематологии»; ORCID: 0000-0003-1494-7978 Moscow, Russia

V V Ryzhko

National Research Center for Hematology

к.м.н., врач-гематолог отд-ния интенсивной высокодозной химиотерапии гематологических заболеваний с круглосуточным и дневным стационарами ФГБУ «НМИЦ гематологии»; ORCID: 0000-0003-1221-3495 Moscow, Russia

M A Samtsova

National Research Center for Hematology

врач-гематолог отд-ния интенсивной высокодозной химиотерапии гематологических заболеваний с круглосуточным и дневным стационарами ФГБУ «НМИЦ гематологии»; ORCID: 0000-0001-9984-389X Moscow, Russia

E O Gribanova

National Research Center for Hematology

к.м.н., врач-гематолог, зав. отд-нием интенсивной высокодозной химиотерапии гематологических заболеваний с круглосуточным и дневным стационарами ФГБУ «НМИЦ»; ORCID: 0000-0002-4155-7820 Moscow, Russia

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