The role of translocations involving c-MYC/8q24, BCL2/18q21 and/or BCL6/3q27 genes in patients with follicular lymphoma. Retrospective analysis of single - centre data
- Authors: Misyurina AE1, Kravchenko SK1, Kovrigina AM1, Magomedova AU1, Plastinina LV1, Obukhova TN1, Misyurin AV2, Misyurin VA2, Grebenuk LA1, Babaeva FE1, Baryakh EA3, Vorobiev AI1
-
Affiliations:
- National Research Center for Hematology
- Blokhin National Medical Cancer Research Center
- City Clinical Hospital №52
- Issue: Vol 91, No 7 (2019)
- Pages: 52-62
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/33600
- DOI: https://doi.org/10.26442/00403660.2019.07.000070
- ID: 33600
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Abstract
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##article.viewOnOriginalSite##About the authors
A E Misyurina
National Research Center for Hematology
Email: anna.lukina1@gmail.com
к.м.н., врач-гематолог отд-ния интенсивной высокодозной химиотерапии гемобластозов с круглосуточным и дневным стационаром ФГБУ «НМИЦ гематологии» Минздрава России Moscow, Russia
S K Kravchenko
National Research Center for Hematologyк.м.н., зав. отд-нием интенсивной высокодозной химиотерапии гемобластозов с круглосуточным и дневным стационаром ФГБУ «НМИЦ гематологии» Минздрава России Moscow, Russia
A M Kovrigina
National Research Center for Hematologyд.б.н., проф., зав. патологоанатомическим отд-нием ФГБУ «НМИЦ гематологии» Минздрава России Moscow, Russia
A U Magomedova
National Research Center for Hematologyд.м.н., в.н.с. отд-ния интенсивной высокодозной химиотерапии гемобластозов с круглосуточным и дневным стационаром ФГБУ «НМИЦ гематологии» Минздрава России Moscow, Russia
L V Plastinina
National Research Center for Hematologyк.м.н., врач-гематолог консультативного гематологического отд-ния с дневным стационаром по проведению интенсивной высокодозной химиотерапии ФГБУ «НМИЦ гематологии» Минздрава России Moscow, Russia
T N Obukhova
National Research Center for Hematologyк.м.н., зав. лаб. кариологии ФГБУ «НМИЦ гематологии» Минздрава России Moscow, Russia
A V Misyurin
Blokhin National Medical Cancer Research Centerд.б.н., зав. лаб. рекомбинантных опухолевых антигенов ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России Moscow, Russia
V A Misyurin
Blokhin National Medical Cancer Research Centerк.б.н., с.н.с. лаб. экспериментальной диагностики и биотерапии опухолей ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России Moscow, Russia
L A Grebenuk
National Research Center for Hematologyлабораторный генетик лаб. кариологии ФГБУ «НМИЦ гематологии» Минздрава России Moscow, Russia
F E Babaeva
National Research Center for Hematologyврач-гематолог отд-ния интенсивной высокодозной химиотерапии гемобластозов круглосуточным и дневным стационаром ФГБУ «НМИЦ гематологии» Минздрава России Moscow, Russia
E A Baryakh
City Clinical Hospital №52врач-гематолог отд-ния гематологии и интенсивной терапии ГКБ №52 Moscow, Russia
A I Vorobiev
National Research Center for Hematologyакад. РАН, д.м.н., проф., главный н.с. отд-ния интенсивной высокодозной химиотерапии гемобластозов с круглосуточным и дневным стационаром ФГБУ «НМИЦ гематологии» Минздрава России Moscow, Russia
References
- Aukema S.M, Siebert R, Schuuring E, van Imhoff G.W, Kluin-Nelemans H.C, Boerma E.J, Kluin P.M. Double - hit B-cell lymphomas. Blood. 2011;117:2319-31. doi: 10.1182/blood-2010-09-297879
- Мисюрин А.В. Основы молекулярной диагностики онкогематологических заболеваний. Российский биотерапевтический журнал. 2016;15(4):18-24. doi: 10.17650/1726-9784-2016-15-4-18-24
- Li S, Lin P, Young K.H, Kanagal-Shamanna R, Yin C.C, Medeiros L.J. MYC/BCL2 double - hit high - grade B-Cell lymphoma. Advances in anatomic pathology. 2013;20:315-26. doi: 10.1097/PAP.0b013e3182a289f2
- Johnson N.A, Savage K.J, Ludkovski O, Ben-Neriah S, Woods R, Steidl C, Dyer M.J, Siebert R, Kuruvilla J, Klasa R, Connors J.M, Gascoyne R.D, Horsman D.E. Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival. Blood. 2009;114:2273-9. doi: 10.1182/blood-2009-03-212191
- Le Gouill S, Talmant P, Touzeau C, Moreau A, Garand R, Juge-Morineau N, Gaillard F, Gastinne T, Milpied N, Moreau P, Harousseau J.L, Avet-Loiseau H. The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement. Haematologica. 2007;92:1335-42. doi: 10.3324/haematol.11305
- Lin P, Medeiros L.J. High - grade B-cell lymphoma/leukemia associated with t(14;18) and 8q24/MYC rearrangement: a neoplasm of germinal center immunophenotype with poor prognosis. Haematologica. 2007;92:1297-301. doi: 10.3324/haematol.11263
- Niitsu N, Okamoto M, Miura I, Hirano M. Clinical features and prognosis of de novo diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC translocations. Leukemia. 2009;23:777-83. doi: 10.1038/leu.2008.344
- Pedersen M.O, Gang A.O, Poulsen T.S, Knudsen H, Lauritzen A.F, Nielsen S.L, Gang U.O, Norgaard P. Double - hit BCL2/MYC translocations in a consecutive cohort of patients with large B-cell lymphoma - a single center's experience. European J Hematology. 2012;89:63-71. doi: 10.1111/j.1600-0609.2012.017 87.x
- Snuderl M, Kolman O.K, Chen Y.B, Hsu J.J, Ackerman A.M, Dal Cin P, Ferry J.A, Harris N.L, Hasserjian R.P, Zukerberg L.R, Abramson J.S, Hochberg E.P, Lee H, Lee A.I, Toomey C.E, Sohani A.R. B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma. American J Surgical Pathology. 2010;34:327-40. doi: 10.1097/ PAS.0b013e3181cd3aeb
- Барях Е.А., Мисюрина А.Е., Ковригина А.М., Мисюрин В.А., Кравченко С.К. B-клеточная лимфома, неклассифицируемая, занимающая промежуточное положение между диффузной B-крупноклеточной лимфомой и лимфомой Беркитта. Терапевтический архив. 2015;87(4):91-7. doi: 10.17116/terarkh201587491-97
- Ji M, Jang S, Lee J.H, Seo E.J. Double - hit myeloma with IGH/MYC and IGH/CCND1 translocations. Ann Hematol. 2013;92(8):1129-31. doi: 10.1007/ s00277-012-1668-y
- Hao S, Sanger W, Onciu M, Lai R, Schlette E.J, Medeiros L.J. Mantle cell lymphoma with 8q24 chromosomal abnormalities: a report of 5 cases with blastoid features. Mod Pathol. 2002;15:1266-72. doi: 10.1097/01.MP.0000 037310.82136.99
- Huh Y.O, Lin K.I, Vega F, Schlette E, Yin C.C, Keating M.J, Luthra R, Medeiros L.J, Abruzzo L.V. MYC translocation in chronic lymphocytic leukaemia is associated with increased prolymphocytes and a poor prognosis. Br J Haematol. 2008;142:36-44. doi: 10.1111/j.1365-2141.2008.07152.x
- Mohamed A.N, Palutke M, Eisenberg L, Al-Katib A. Chromosomal analyses of 52 cases of follicular lymphoma with t(14;18), including blastic/blastoid variant. Cancer Genetics and Cytogenetics. 2001;126:45-51.
- Horn H, Schmelter C, Leich E, Salaverria I, Katzenberger T, Ott M.M, Kalla J, Romero M, Siebert R, Rosenwald A, Ott G. Follicular lymphoma grade 3b is a distinct neoplasm according to cytogenetic and immunohistochemical profiles. Haematologica. 2011;96(9):1327-34. doi: 10.3324/haematol.2011.042531
- Bosga-Bouwer A.G, van den Berg A, Haralambieva E, de Jong D, Boonstra R, Kluin P, van den Berg E, Poppema S. Molecular, cytogenetic, and immunophenotypic characterization of follicular lymphoma grade 3B; a separate entity or part of the spectrum of diffuse large B-cell lymphoma or follicular lymphoma? Hum Pathol. 2006;37(5):528-33. doi: 10.1016/j.hum path.2005.12.005
- Ott G, Rosenwald A, Campo E. Understanding MYC-driven aggressive B-cell lymphomas: pathogenesis and classification. Blood. 2013;122(24):3884-91. doi: 10.1182/blood-2013-05-498329
- Korac P, Dotlic S, Domins M. "Double hit" lymphoma or secondary MYC translocation lymphoma? Period biol. 2012;114(4):527-37. doi: 10.3390/genes 8040115
- Macpherson N, Lesack D, Klasa R, Horsman D, Connors J.M, Barnett M, Gascoyne R.D. Small Noncleaved, Non-Burkitt's (Burkitt-Like) Lymphoma: Cytogenetics Predict Outcome and Reflect Clinical Presentation. J Clin Oncol. 1999;17(5):1558-67. doi: 10.1200/JCO.1999.17.5.1558
- Барях Е.А., Мисюрина А.Е., Ковригина А.М., Обухова Т.Н., Кравченко С.К., Магомедова А.У., Зингерман Б.В., Мисюрина Е.Н., Потешкина Н.Г., Лысенко М.А., Воробьев А.И. Клинические особенности и терапия double - hit и double - expressor лимфом. Современная онкология. 2016;18(5):22-30.
- Swerdlow S.H, Campo E, Harris N.L, Jaffe E.S, Pileri S.A, Stein H, Thiele J, Vardiman J.W. Classification of Tumours of Haematopoietic and Lymphoid Tissues. WHO Classification of Tumours, Revised 4th Edition, Volume 2. Lyon: IARC Press, 2017.
- Momose S, Weißbach S, Pischimarov J, Nedeva T, Bach E, Rudelius M, Geissinger E, Staiger A.M, Ott G, Rosenwald A. The diagnostic gray zone between Burkitt lymphoma and diffuse large B-cell lymphoma is also a gray zone of the mutational spectrum. Leukemia. 2015;29(8):1789-91. doi: 10.1038/ leu.2015.34
- Swerdlow S.H. Diagnosis of 'double hit' diffuse large B-cell lymphoma and B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma: when and how, FISH versus IHC. Hematology Am Soc Hematol Educ Program. 2014;(1):90-9. doi: 10.1182/asheducation-2014.1.90
- Campo E. MYC in DLBCL: partners matter. Blood. 2015;126(22):2439-40. doi: 10.1182/blood-2015-10-671362
- Hummel M, Bentink S, Berger H, Klapper W, Wessendorf S, Barth TF, Bernd H.W, Cogliatti S.B, Dierlamm J, Feller A.C, Hansmann M.L, Haralambieva E, Harder L, Hasenclever D, Kühn M, Lenze D, Lichter P, Martin-Subero J.I, Möller P, Müller-Hermelink H.K, Ott G, Parwaresch R.M, Pott C, Rosenwald A, Rosolowski M, Schwaenen C, Stürzenhofecker B, Szczepanowski M, Trautmann H, Wacker H.H, Spang R, Loeffler M, Trümper L, Stein H, Siebert R. Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe. A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N Engl J Med. 2006;354(23):2419-30. doi: 10.1056/NEJMoa055351
- Li S, Lin P, Fayad L.E, Lennon P.A, Miranda R.N, Yin C.C, Lin E, Medeiros L.J. B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18)(q32;q21): an aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome. Modern Pathology. 2012;25:145-56. doi: 10.1038/modpathol.2011.147
- Cheah C.Y, Oki Y, Westin J.R, Turturro F. A clinician's guide to double hit lymphomas. Br J Haematol. 2015;168(6):784-95. doi: 10.1111/bjh.13276
- Tomita N, Tokunaka M, Nakamura N, Takeuchi K, Koike J, Motomura S, Miyamoto K, Kikuchi A, Hyo R, Yakushijin Y, Masaki Y, Fujii S, Hayashi T, Ishigatsubo Y, Miura I. Clinicopathological features of lymphoma/ leukemia patients carrying both BCL2 and MYC translocations. Haematologica. 2009; 94(7):935-43. doi: 10.3324/haematol.2008.005355
- Oki Y, Noorani M, Lin P, Davis R.E, Neelapu S.S, Ma L, Ahmed M, Rodriguez M.A, Hagemeister F.B, Fowler N, Wang M, Fanale M.A, Nastoupil L, Samaniego F, Lee H.J, Dabaja B.S, Pinnix C.C, Medeiros L.J, Nieto Y, Khouri I, Kwak L.W, Turturro F, Romaguera J.E, Fayad L.E, Westin J.R. Double hit lymphoma: the MD Anderson Cancer Center clinical experience. Br J Haematol. 2014;166(6):891-901. doi: 10.1111/bjh.12982
- Petrich A.M, Gandhi M, Jovanovic B, Castillo J.J, Rajguru S, Yang D.T, Shah K.A, Whyman J.D, Lansigan F, Hernandez-Ilizaliturri F.J, Lee L.X, Barta S.K, Melinamani S, Karmali R, Adeimy C, Smith S, Dalal N, Nabhan C, Peace D, Vose J, Evens A.M, Shah N, Fenske T.S, Zelenetz A.D, Landsburg D.J, Howlett C, Mato A, Jaglal M, Chavez J.C, Tsai J.P, Reddy N, Li S, Handler C, Flowers C.R, Cohen J.B, Blum K.A, Song K, Sun H.L, Press O, Cassaday R, Jaso J, Medeiros L.J, Sohani A.R, Abramson J.S. Impact of induction regimen and stem cell transplantation on outcomes in double - hit lymphoma: a multicenter retrospective analysis. Blood. 2014;124(15):2354-61. doi: 10.1182/blood-20 14-05-578963
- Sun H, Savage K.J, Karsan A, Slack G.W, Gascoyne R.D, Toze C.L, Sehn L.H, Abou Mourad Y, Barnett M.J, Broady R.C, Connors J.M, Forrest D.L, Gerrie A.S, Hogge D.E, Narayanan S, Nevill T.J, Nantel S.H, Power M.M, Sutherland H.J, Villa D, Shepherd J.D, Song K.W. Outcome of Patients With Non-Hodgkin Lymphomas With Concurrent MYC and BCL2 Rearrangements Treated With CODOX-M/IVAC With Rituximab Followed by Hematopoietic Stem Cell Transplantation. H Sun, Clinical Lymphoma, Myeloma & Leukemia. 2015; 15(6):341-8. doi: 10.1016/j.clml.2014.12.015
- Kanagal-Shamanna R, Medeiros L.J, Lu G, Wang S.A, Manning J.T, Lin P, Penn G.M, Young K.H, You M.J, Vega F, Bassett R, Miranda R.N. High - grade B cell lymphoma, unclassifiable, with blastoid features: an unusual morphological subgroup associated frequently with BCL2 and/or MYC gene rearrangements and a poor prognosis. Histopathology. 2012;61(5):945-54. doi: 10.1111/j.1365-2559.2012.04301.x
- Li S, Saksena A, Desai P, Xu J, Zuo Z, Lin P, Tang G, Yin C.C, Seegmiller A, Jorgensen J.L, Miranda R.N, Reddy N.M, Bueso-Ramos C, Medeiros L.J. Prognostic impact of history of follicular lymphoma, induction regimen and stem cell transplant in patients with MYC/BCL2 double hit lymphoma. Oncotarget. 2016;7(25):38122-32. doi: 10.18632/oncotarget.9473
- Christie L, Kernohan N, Levison D, Sales M, Cunningham J, Gillespie K, Batstone P, Meiklejohn D, Goodlad J. C-MYC translocation in t(14;18) positive follicular lymphoma at presentation: An adverse prognostic indicator? Leuk lymphoma. 2008;49:470-6. doi: 10.1080/10428190701836845
- Yano T, Jaffe E.S, Longo D.L, Raffeld M. MYC rearrangements in histologically progressed follicular lymphomas. Blood. 1992;80:758-67.
- Vafaii P, Shao H. “Double hit” follicular lymphoma with low proliferation index: A unique case and literature review. Adv Mod Oncol Res. 2017; 3(2):126-30. doi: 10.18282/amor.v3.i3.169
- Kanda-Akano Y, Nomura K, Fujita Y, Horiike S, Nishida K, Nagai M, Miura I, Nakamura S, Seto M, Iida S, Ueda R, Taniwaki M. Molecular - cytogenetic characterization of non-Hodgkin’s lymphoma with double and cryptic translocations of the immunoglobulin heavy chain gene. Leuk Lymphoma. 2004;45(8):1559-67. doi: 10.1080/10428190310001625674
- Voorhees P.M, Carder K.A, Smith S.V, Ayscue L.H, Rao K.W, Dunphy C.H. Follicular lymphoma with a Burkitt translocation - Predictor of an aggressive clinical course: A case report and review of the literature. Arch Pathol Lab Med. 2004;128(2):210-3. doi: 10.1043/1543-2165(2004)128<210:FLWABT> 2.0.CO;2
- Kanungo A, Medeiros L.J, Abruzzo L.V, Lin P. Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/ c-MYC translocation generally have a poor prognosis. Mod Pathol. 2006;19(1):25-33. doi: 10.1038/mod pathol.3800500
- Miao Y, Hu S, Lu X, Li S, Wang W, Medeiros L.J, Lin P. Double - hit follicular lymphoma with MYC and BCL2 translocations: A study of 7 cases with a review of literature. Hum Pathol. 2016;58:72-7. doi: 10.1016/j.humpath. 2016.07.025
- Kridel R, Sehn L.H, Gascoyne R.D. Can Histologic Transformation of Follicular Lymphoma Be Predicted and Prevented? Blood. 2017;130(3):258-66. doi: 10.1182/blood-2017-03-691345
- Pasqualucci L, Khiabanian H, Fangazio M, Vasishtha M, Messina M, Holmes A.B, Ouillette P, Trifonov V, Rossi D, Tabbò F, Ponzoni M, Chadburn A, Murty V.V, Bhagat G, Gaidano G, Inghirami G, Malek S.N, Rabadan R, Dalla-Favera R. Genetics of Follicular Lymphoma Transformation. Cell Rep. 2014;6(1):130-40. doi: 10.1016/j.celrep.2013.12.027
- Lo Coco F, Gaidano G, Louie D.C, Offit K, Chaganti R.S, Dalla-Favera R. P53 mutations are associated with histologic transformation of follicular lymphoma. Blood. 1993;82(8):2289-95.
- Sander C.A, Yano T, Clark H.M, Harris C, Longo D.L, Jaffe E.S, Raffeld M. P53 mutation is associated with progression in follicular lymphomas. Blood. 1993; 82(7):1994-2004.
- Au W.Y, Horsman D.E, Gascoyne R.D, Viswanatha D.S, Klasa R.J, Connors J.M. The spectrum of lymphoma with 8q24 aberrations: a clinical, pathological and cytogenetic study of 87 consecutive cases. Leuk Lymphoma. 2004;45(3):519-28.
- Lossos I.S, Alizadeh A.A, Diehn M, Warnke R, Thorstenson Y, Oefner P.J, Brown P.O, Botstein D, Levy R. Transformation of follicular lymphoma to diffuse large - cell lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes. Proc Natl Acad Sci USA. 2002; 99(13):8886-91. doi: 10.1073/pnas.132253599
- Alhejaily A, Day A.G, Feilotter H.E, Baetz T, Lebrun D.P. Inactivation of the CDKN2A tumor suppressor gene by deletion or methylation is common at diagnosis in follicular lymphoma and associated with poor clinical outcome. Clin Cancer Res. 2014;20(6):1676-86. doi: 10.1158/1078-0432.CCR-13-2175
- Fitzgibbon J, Iqbal S, Davies A, O'shea D, Carlotti E, Chaplin T, Matthews J, Raghavan M, Norton A, Lister T.A, Young B.D. Genome - wide detection of recurring sites of uniparental disomy in follicular and transformed follicular lymphoma. Leukemia. 2007;21(7):1514-20. doi: 10.1038/sj.leu.2404696
- Elenitoba-Johnson K.S, Gascoyne R.D, Lim M.S, Chhanabai M, Jaffe E.S, Raffeld M. Homozygous deletions at chromosome 9p21 involving p16 and p15 are associated with histologic progression in follicle center lymphoma. Blood. 1998;91(12):4677-85.
- Pinyol M, Cobo F, Bea S, Jares P, Nayach I, Fernandez P.L, Montserrat E, Cardesa A, Campo E. p16(INK4a) gene inactivation by deletions, mutations, and hypermethylation is associated with transformed and aggressive variants of non-Hodgkin’s lymphomas. Blood. 1998;91(8):2977-84.
- Vaidyanathan G, Ngamphaiboon N, Hernandez-Ilizaliturri F.J. Clinical spectrum and prognosis of follicular lymphoma with blastoid transformation: case series and a review of the literature. Ann Hematol. 2011;90(8):955-62. doi: 10.1007/s00277-011-1162-y
- Natkunam Y, Warnke R.A, Zehnder J.L, Jones C.D, Milatovich-Cherry A, Cornbleet P.J. Blastic/Blastoid Transformation of Follicular Lymphoma: Immunohistologic and Molecular Analyses of Five Cases. Amer J Surgical Pathology. 2000;24(4):525-34.
- Нестерова Е.С., Кравченко С.К., Мангасарова Я.К., Барях Е.А., Мисюрина А.Е., Воробьев В.И., Пластинина Л.В., Чернова Н.Г., Ковригина А.М., Обухова Т.Н., Клясова Г.А., Шевелев А.А., Костина И.Э., Гемджян Э.Г., Гапонова Т.В., Воробьев А.И. Фолликулярная лимфома. Высокодозная иммунохимиотерапия с трансплантацией аутологичных стволовых клеток крови: результаты первого проспективного исследования в России. Терапевтический архив. 2016;88(7):62-71. doi: 10.17116/terarkh201688762-71
- Yunis J.J, Soreng A.L. Constitutive fragile sites and cancer. Science. 1984;226:1199-204.
- Thangavelu M, Olopade O, Beckman E, Vardiman J.W, Larson R.A, McKeithan T.W, Le Beau M.M, Rowley J.D. Clinical, morphologic, and cytogenetic characteristics of patients with lymphoid malignancies characterized by both t(14;18)(q32;q21) and t(8;14)(q24; q32) or t(8;22)(q24;q11). Genes Chromosomes Cancer. 1990;2:147-58.
- Offit K, Jhanwar S.C, Ladanyi M, Filippa D.A, Chaganti R.S. Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin’s lymphoma: correlations between recurrent aberrations, histology, and exposure to cytotoxic treatment. Genes Chromosomes Cancer. 1991;3:189-201.
- Karsan A, Gascoyne R.D, Coupland R.W, Shepherd J.D, Phillips G.L, Horsman D.E. Combination of t(14;18) and a Burkitt’s type translocation in B-cell malignancies. Leuk Lymphoma. 1993;10;433-41.
- Stamatoullas A, Buchonnet G, Lepretre S, Lenain P, Lenormand B, Duval C, Callat M.P, Gaulard P, Bastard C, Tilly H. De novo acute B-cell leukemia/lymphoma with t(14;18). Leukemia. 2000;14:1960-6.
- Cohen J.B, Geyer S.M, Lozanski G, Zhao W, Heerema N.A, Hall N.C, Nagar V.A, Hemminger J.A, Jones J.A, Porcu P, Christian B.A, Baiocchi R.A, Maddocks K.J, Flynn J.M, Devine S.M, Blum K.A. Complete response to induction therapy in patients with Myc - positive and double - hit non-Hodgkin lymphoma is associated with prolonged progression - free survival. Cancer. 2014; 120(11):1677-85. doi: 10.1002/cncr.28642
- Boerma E.G, Siebert R, Kluin P.M, Baudis M. Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of today’s knowledge. Leukemia. 2009;23(2):225-34. doi: 10.1038/leu.2008.281
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