Analysis of the gene polymorphism of matrix metalloproteinase-2 and -9 in patients with coronary heart disease
- Authors: Shevchenko A.V.1, Golovanova O.V.1, Konenkov V.I.1, Tolkacheva O.M.2, Maksimov V.N.3, Voevoda M.I.3, Romashchenko A.G.4, Shevchenko AV5, Golovanova OV5, Konenkov VI5, Tolkacheva OM6, Maksimov VN7, Voyevoda MI7, Romashchenko AG8
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Affiliations:
- ГУ НИИ клинической и экспериментальной лимфологии СО РАМН, Новосибирск, лаборатория клинической иммуногенетики
- городская клиническая больница № 29
- ГУ НИИ терапии СО РАМН
- Институт цитологии и генетики СО РАН
- Clinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical Sciences
- Town Clinical Hospital Twenty-Nine
- Research Institute of Therapy, Siberian Branch, Russian Academy of Medical Sciences
- Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences
- Issue: Vol 82, No 1 (2010)
- Pages: 31-34
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/33382
- ID: 33382
Cite item
Full Text
Abstract
Materials and methods. The influence of single nucleotide polymorphism in the promoter region of the gene of matrix metalloproteinase (MMP)-2 at position -1306 and that of MMP-9 at position -1562 on the development of complications was studied in 181 patients with atherosclerosis by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of amplification products.
Results. A significant genotype increase with enhanced MMP-9 gene transcriptional activity was found in the patients aged 55 years inclusively who had been diagnosed as having myocardial infarction as compared with an older age group and, on the contrary, a rise in the MMP-2 genotype with a high promoter activity in the older age group.
Conclusion. The findings suggest that the functional polymorphism in the promoter region of the MMP-2 and MMP-9 genes plays a certain role in the development of acute coronary events.
About the authors
Alla Vladimirovna Shevchenko
ГУ НИИ клинической и экспериментальной лимфологии СО РАМН, Новосибирск, лаборатория клинической иммуногенетики
Email: shalla64@mail.ru
канд. биол. наук, ст. науч. сотр., лаб. клинической иммуногенетики; ГУ НИИ клинической и экспериментальной лимфологии СО РАМН, Новосибирск, лаборатория клинической иммуногенетики
Ol'ga Valer'evna Golovanova
ГУ НИИ клинической и экспериментальной лимфологии СО РАМН, Новосибирск, лаборатория клинической иммуногенетики
Email: golovanova_olga@mail.ru
канд. биол. наук, ст. научн. сотр., лаб. клинической иммуногенетики; ГУ НИИ клинической и экспериментальной лимфологии СО РАМН, Новосибирск, лаборатория клинической иммуногенетики
Vladimir Iosifovich Konenkov
ГУ НИИ клинической и экспериментальной лимфологии СО РАМН, Новосибирск, лаборатория клинической иммуногенетики
Email: konen@soramn.ru
проф., акад. РАМН, дир. НИИ клинической и экспериментальной лимфологии СО РАМН; ГУ НИИ клинической и экспериментальной лимфологии СО РАМН, Новосибирск, лаборатория клинической иммуногенетики
Ol'ga Mikhaylovna Tolkacheva
городская клиническая больница № 29
Email: tolkacheva-olga@mail.ru
аспирант, НИИ терапии СО РАМН; городская клиническая больница № 29
Vladimir Nikolaevich Maksimov
ГУ НИИ терапии СО РАМН
Email: medik11@mail.ru
д-р мед. наук, вед. науч. сотр., лаб. молекулярно-генетических исследований; ГУ НИИ терапии СО РАМН
Mikhail Ivanovich Voevoda
ГУ НИИ терапии СО РАМН
Email: voevoda@iimed.ru
д-р мед. наук, проф., член-корр. РАМН, дир. НИИ терапии СО РАМН; ГУ НИИ терапии СО РАМН
Aida Gerasimovna Romashchenko
Институт цитологии и генетики СО РАН
Email: romasch@bionet.nsc.ru
канд. биол. наук, зав. лабораторией, лаб. молекулярных основ генетики животных; Институт цитологии и генетики СО РАН
A V Shevchenko
Clinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical SciencesClinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical Sciences
O V Golovanova
Clinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical SciencesClinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical Sciences
V I Konenkov
Clinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical SciencesClinical Immunogenetics Laboratory, Research Institute of Clinical and Experimental Lymphology, Siberian Branch, Russian Academy of Medical Sciences
O M Tolkacheva
Town Clinical Hospital Twenty-NineTown Clinical Hospital Twenty-Nine
V N Maksimov
Research Institute of Therapy, Siberian Branch, Russian Academy of Medical SciencesResearch Institute of Therapy, Siberian Branch, Russian Academy of Medical Sciences
M I Voyevoda
Research Institute of Therapy, Siberian Branch, Russian Academy of Medical SciencesResearch Institute of Therapy, Siberian Branch, Russian Academy of Medical Sciences
A G Romashchenko
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of SciencesInstitute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences
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