Association of SOCS5 gene polymorphism with allergic bronchial asthma


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Abstract

Aim: to study the association of mononucleotide polymorphism rs6737848 SOCS5 gene with the risk of development of allergic bronchial asthma. Material and methods. Totally 59 patients studied (19 males, 40 females) with allergic bronchial asthma and 50 healthy people (29 males, 21 females) of controls. All patients underwent clinical and instrumental and laboratory investigations in KICH №20 (Krasnoyarsk city) and molecular-genetic investigation of DNA in the Russia-Italian laboratory “MAGI” (Krasnoyarsk city) and Institution of Internal and Preventive Medicine (Novosibirsk city). Statistics included standard programs: Statistica for Windows 7.0. Results. The results of the study showed statistical predominance of prevalent genotype СС of SOCS5 gene in allergic bronchial asthma patients, comparing to control group. Conclusion. Homozygous genotype of СС gene of SOCS5 is a risk factor for allergic bronchial asthma.

About the authors

A B Averyanov

Krasnoyarsk State Medical University named after of professor V.F. Voino-Yasenetsky of the Ministry of Health of the Russian Federation, Department of internal diseases №1

Email: Averyanov_a007@mail.ru
аспирант каф. внутренних болезней №1 ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России; тел.: +7(913)512-98-46; e-mail: Averyanova007@mail.ru; ORCID: 0000-0002-9944-6568

I I Chercashina

Krasnoyarsk State Medical University named after of professor V.F. Voino-Yasenetsky of the Ministry of Health of the Russian Federation, Department of internal diseases №1

д.м.н., проф. каф. внутренних болезней №1 ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России

S Yu Nikulina

Krasnoyarsk State Medical University named after of professor V.F. Voino-Yasenetsky of the Ministry of Health of the Russian Federation, Department of internal diseases №1

д.м.н., проф., зав. каф. внутренних болезней №1, проректор по учебной работе ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России

V N Maksimov

Research Institutе of Internal and Preventive Medicine - Branch of the Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences

д.м.н., проф., зав. лаб. молекулярно-генетических исследований терапевтических заболеваний НИИТПМ - филиал ИЦиГ СО РАН

V A Shestovitskiy

Prof. V.F. Voino-Yasenetski Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation, Department of Therapy

д.м.н., проф., каф. терапии ИПО ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России

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