Vitamin D deficiency and cardiovascular pathology


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Abstract

Vitamin D deficiency is widespread worldwide and present in about 30-50% of population. In most cases, this problem is associated with musculoskeletal system pathology: rickets in children, and osteomalacia or osteoporosis in adults. However, in recent years, convincing data was obtained on the links between vitamin D deficiency and cardiovascular pathology. Low Vitamin D levels in humans are associated with the unfavorable cardiovascular risk factors, such as arterial hypertension (AH), diabetes mellitus, and dyslipidemia, which are the predictors of the severe cardiovascular diseases, including strokes and infarctions. It has been demonstrated that vitamin D has a strong vasoptotective effect via endothelial dysfunction improvement, prevents blood vessels and myocardium remodeling, improves blood pressure parameters, reduces the risk of development of left ventricular hypertrophy, slows down fibrosis, reduces the risk of atherosclerosis, reduces insulin resistance, and also affects inflammation and immunity. This article provides data of Russian and foreign studies demonstrating the effect of Vitamin D deficiency on the development of atherosclerosis, AH, heart rhythm disorder and progression of chronic heart failure.

About the authors

V I Podzolkov

Federal state Autonomous educational institution of higher professional education First Moscow state medical University named after I.M. Sechenov of Ministry of Health of the Russian Federation (Sechenov University)

д.м.н., проф., зав. каф. фак. терапии №2, директор фак. терапевтической клиники УКБ №4, http://orcid.org/0000-0002-0758-5609 Moscow, Russia

A E Pokrovskaya

Federal state Autonomous educational institution of higher professional education First Moscow state medical University named after I.M. Sechenov of Ministry of Health of the Russian Federation (Sechenov University)

к.м.н., доцент каф. фак. терапии №2; тел.: 8(903)195-78-70; e-mail: a.e.pokrovskaya@mail.ru; http://orcid.org/0000-0002-8875-9032 Moscow, Russia

O I Panasenko

Federal state Autonomous educational institution of higher professional education First Moscow state medical University named after I.M. Sechenov of Ministry of Health of the Russian Federation (Sechenov University)

студентка Ⅴ курса лечебного фак-та, https://orcid.org/0000-0003-3656-5655 Moscow, Russia

References

  1. Дедов И.И., Мельниченко Г.А. Клинические рекомендации. Дефицит витамина D: диагностика, лечение и профилактика. М., 2014; с.10-5.
  2. Wang T.J, Pencina M.J, Booth S.L, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008;117:503-51. https://doi.org/10.1161/circulationaha.107.706127
  3. Giovannucci E, Liu Y, Hollis B.W, Rimm E.B. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008;168:1174-80. https://doi.org/10.1001/archinte.168.11.1174
  4. Dobnig H, Pilz S, Scharnagl H, et al. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin D levels with all - cause and cardiovascular mortality. Arch Intern Med. 2008;168:1340-49. https://doi.org/10.1001/archinte.168.12.1340
  5. Tomson J, Emberson J, Hill M, et al. Vitamin D and risk of death from vascular and non - vascular causes in the Whitehall study and meta - analyses of 12 000 deaths. Eur Heart J. 2013;34(18):1365-74. https://doi.org/10.1093/eurheartj/ehs426
  6. Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation. 2004;109(Suppl 1): III27-III32. doi: 10.1161/01.CIR. 0000131515.03336.f8
  7. Lavie C.J, Dinicolantonio J.J, Milani R.V. Vitamin D and cardiovascular health. Circulation. 2013;128:2404-6. https://doi.org/10.1161/circulationaha.113.002902
  8. Menezes A.R, Lamb M.C, Lavie C.J, Di Nicolantonio J.J. Vitamin D and atherosclerosis. Curr Opin Cardiol. 2014;29(6):571-7. https://doi.org/10.1097/hco.0000000000000108
  9. Norman P.E, Powell J.T. Vitamin D and Cardiovascular Disease. Circulation Research. 2014;114:379-93. https://doi.org/10.1161/circresaha. 113.301241
  10. Melaku L, Mossie A. Molecular mediators and controlling mechanism of vascular calcification. Int J Clin Exp Physiol. 2017;4:3-14. https://doi.org/10.4103/ijcep.ijcep_3_17
  11. Hsu J.J, Tintut Y, Demer L.L. Vitamin D and osteogenic differentiation in the artery wall. Clin J Am Soc Nephrol. 2008 Sep;3(5):1542-7. https://doi.org/10.2215/cjn.01220308
  12. Mayer O.Jr, Filipovský J, Seidlerová J, Vaněk J, Dolejšová M, Vrzalová J, Cífková R. The association between low 25-hydroxyvitamin D and increased aortic stiffness. J Hum Hypertens. 2012 Nov;26(11):650-5. https://doi.org/10.1038/jhh.2011.94
  13. Holick M.F. Vitamin D and Health: Evolution, Biologic, Functions, and Recommended Dietary Intakes for Vitamin D. Clinic Rev Bone Miner Metab. 2009;7:2-19. https://doi.org/10.1007/s12018-009-9026-x
  14. Nathan Carlson, Robert Mah, Maria Aburto, Mark Jason Peters, Meagan V Dupper, Lie Hong Chen. Hypovitaminosis D. Correction and High-Sensitivity C-Reactive Protein Levels in Hypertensive Adults. Perm J. 2013 Fall;17(4):19-21. https://doi.org/10.7812/tpp/13-007
  15. Liefaard M.C, Ligthart S, Vitezova A, Hofman A, Uitterlinden A.G, Kiefte de Jong J.C, et al. Vitamin D and C-Reactive Protein: A Mendelian Randomization Study. PLoS ONE. 2015;10(7):e0131740. https://doi.org/ 10.1371/journal.pone. 0131740
  16. Zittermann A, Schulze Schleithoff S, Tenderich G, Berthold H.K, Korfer T, et al. Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? J Am Coll Cardiol. 2003 Jan; 41:105-12. https://doi.org/10.1016/s0735-1097(02)02624-4
  17. Zittermann A, Dembinski J, Stehle P. Low vitamin D status is associated with low cord blood levels of the immunosuppressive cytokine interleukin-10. Pediatr Allergy Immunol. 2004;15:242-6. https://doi.org/ 10.1111/j.1399-3038.2004.00140.x
  18. Mallat Z, Besnard S, Duriez M, et al. Protective role of interleukin-10 in atherosclerosis. Circ Res. 1999;85:E17-24. https://doi.org/10.1161/ 01.res.85.8.e17
  19. Schleithoff S.S, Zittermann A, Tenderich G, Berthold H.K, Stehle P, Koerfer R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double - blind, randomized, placebo - controlled trial. Am J Clin Nutr. 2006;83:754-9. https://doi.org/ 10.1093/ajcn/83.4.754
  20. Hlavatya Tibor, Krajcovicovaa Anna, Payerb Juraj. Vitamin D Therapy in Inflammatory Bowel Diseases: Who, in What Form, and How Much? J Crohn's and Colitis. 2015;198-209. https://doi.org/10.1093/ ecco-jcc/jju004
  21. Dadaei T, Safapoor M.H, Asadzadeh Aghdaei H, Balaii H, Pourhoseingholi M.A, Naderi N, et al. Effect of vitamin D3 supplementation on TNF-α serum level and disease activity index in Iranian IBD patients. Gastroenterol Hepatol Bed Bench. 2015;8(1):49-55.
  22. Lynn Kane, Kelly Moore, Dieter Lütjohann, et al. Vitamin D3 Effects on Lipids Differ in Statin and NonStatin-Treated Humans: Superiority of Free 25-OH D Levels in Detecting Relationships. J Clin Endocrinol Metab. 2013 Nov;98(11):4400-9. https://doi.org/10.1210/jc.2013-1922
  23. Jegger D, da Silva R, Jeanrenaud X, Nasratullah M, Tevaearai H, von Segesser L.K, Segers P, Gaillard V, Atkinson J, Lartaud I, Stergiopulo N. Ventricular - arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine. Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1942-51. https://doi.org/10.1152/ajpheart.00091.2006
  24. Rostand S.G. Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension. 1979;30:150-6. https://doi.org/10.1161/01.hyp.30.2.150
  25. Martins D, Wolf M, Pan D, et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2007;167:1159-116524. https://doi.org/10.1001/ archinte.167.11.1159
  26. Forman J.P, Giovannucci E, Holmes M.D, Bischoff-Ferrari H.A, Tworoger S.S, Willett W.C, et al. Plasma 25 hydroxyvitamin D levels and risk of incident hypertension. Hypertension. 2007;49(5):1063-9. https://doi.org/10.1161/hypertensionaha.107.087288
  27. Каронова Т.Л., Андреева А.Т., Злотникова Е.К., Гринева Е.Н. Дефицит витамина D и артериальная гипертензия: что общего? Артериальная гипертензия. 2017;23(4):275-81. https://doi.org/10.18705/1607-419x-2017-23-4-275-281
  28. Forman J.P, Curhan G.C, Taylor E.N. Plasma 25 hydroxyvitamin D levels and risk of incident hypertension among young women. Hypertension. 2008;52(5):828-32. https://doi.org/10.1161/hypertensionaha.107.087288
  29. Mehta V, Agarwal S. Does Vitamin D Deficiency Lead to Hypertension? Cureus. 2017 Feb 17;9(2):e1038. https://doi.org/10.7759/cureus.1038
  30. Драпкина О.М., Шепель Р.Н. Плейотропные эффекты витамина D. Рациональная Фармакотерапия в Кардиологии. 2016;12(2):227-33. https://doi.org/10.20996/1819-6446-2016-12-2-227-233
  31. Andrukhova O, Slavic S, Zeitz U, Riesen S.C, Heppelmann M.S, Ambrisko T.D, et al. Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice. Mol Endocrinol. 2014;28(1):53-64. https://doi.org/10.1210/me.2013-1252
  32. Харламов А.Н., Перриш А.Н., Габинский Я.Л., Ронне Х., Иванова Е.Ю. Витамин D в лечении кардиоренального синдрома у больных хронической нефропатией. Кардиология. 2012;3:33-45
  33. Gunta S.S, Thadhani R.I, Mak R.H. The effect of vitamin D status on risk factors for cardiovascular disease. Nature Reviews Nephrology. 2013;9(6):337-47. doi: 10.1038/nrneph.2013.74
  34. Nadir M.A, Szwejkowski B.R, Witham M.D. Vitamin D and cardiovascular prevention. Cardiovasc Ther. 2010;28(4):5-12. https://doi.org/ 10.1111/j.1755-5922.2010.00192.x
  35. Филатова Т.Е., Низов А.А., Давыдов В.В. Опыт лечения гипертонической болезни у пациентов мужского пола с ожирением, гипергликемией натощак и дефицитом витамина D. Российский медико - биологический вестник им. ак. И.П. Павлова. 2017;25(1):69-75. https://doi.org/10.23888/pavlovj2017169-75
  36. Robert K. Scragg, Carlos A. Camargo Jr. and Robert U. Simpson. Relation of Serum 25-Hydroxyvitamin D to Heart Rate and Cardiac Work (from the National Health and Nutrition). Am J Cardiol. 2010;105:122-8. https://doi.org/10.1016/j.amjcard.2009.08.661
  37. Cerit, Levent Bermuda triangle; heart failure, atrial fibrillation, and vitamin D deficiency. J Cardiovasc Medicine. 2017;18(Issue2):121. https://doi.org/10.2459/jcm.0000000000000407
  38. Shoben A.B, Kestenbaum B, Levin G, et al. Seasonal variation in 25-hydroxyvitamin D concentrations in the cardiovascular health study. Am J Epidemiol. 2011;174:1363-72. https://doi.org/10.1093 /aje/kwr258
  39. Zhiwei Zhang, Yajuan Yang, Chee Yuan Ng, Dandan Wang, Jianlong Wang, Guangping Li, Tong Liu, PhD. Meta - analysis of Vitamin D Deficiencyand Risk of Atrial Fibrillation. Clin. Cardiol. 2016;39(9):537-43. https://doi.org/10.1002/clc.22563
  40. Kimie Ohkubo, Ichiro Watanabe, Yasuo Okumura, et al. Usefulness of High Sensitivity C-Reactive Protein in Predicting Recurrence of Atrial Fibrillation after Electrical Cardioversion. J Nihon Univ Med Ass. 2015;74(5):233-7. https://doi.org/10.4264/numa.74.5_233
  41. Murphy N.F, Stewart S, Mac Intyre K, et al. Seasonal variation in morbidity and mortality related to atrial fibrillation. Int J Cardiol. 2004;97:283-8.
  42. Emren S.V, Aldemir M, Ada F. Does Deficiency of Vitamin D Increase New Onset Atrial Fibrillation after Coronary Artery Bypass Grafting Surgery? Heart Surg Forum. 2016 Aug 22;19(4):180-4. https://doi.org/ 10.1532/hsf.1531
  43. Ларина В.Н., Распопова Т.Н. Минеральная плотность костной ткани и костный обмен при хронической сердечной недостаточности. Кардиология. 2016;56(7):33-45. https://doi.org/10.18565/ cardio.2016.7.39-46
  44. Pilz S, Marz W, Wellnitz B, Seelhorst U, Fahrleitner-Pammer A, Dimai H, Boehm B, Dobnig H. Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross - sectional study of patients referred for coronary angiography. J Clin Endocrinol Metab. 2008;93(10):3927-35. https://doi.org/10.1210/jc.2008-0784
  45. Andersson P, Rydberg E, Willenheimer R. Primary hyperparathyroidism and heart disease a review. Eur Heart J. 2004;25:1776-87. https://doi.org/10.1016/j.ehj.2004.07.010
  46. Finkel T, Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408:239-47. https://doi.org/10.1038/35041687
  47. Kamen D.L, Tangpricha V. Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity. J Mol Med. 2010;88:441-50. https://doi.org/10.1007/s00109-010-0590-9
  48. Hullett D.A, Cantorna M.T, Redaelli C, et al. Prolongation of allograft survival by 1,25-dihydroxy Vitamin D3. Transplantation. 1998;66(7):824-8. https://doi.org/10.1097/00007890-199810150-00002
  49. Драпкина О.М., Шепель Р.Н. Теломеры и хроническая сердечная недостаточность. Кардиология. 2014;54(4):60-7. https://doi.org/10.18565/cardio.2014.4.60-67
  50. Singh N.P, Sahni V, Garg D, Nair M. Effect of pharmacological suppression of secondary hyperparathyroidism on cardiovascular hemodynamics in predialysis CKD patients: a preliminary observation. Hemodial Int. 2007;11:417-23. https://doi.org/10.1111/j.1542-4758.2007.00211.x
  51. Artaza J.N, Mehrotra R, Norris K.C. Vitamin D and the cardiovascular system. Clin J Am Soc Nephrol. 2009;4:1515-22. https://doi.org/10.2215/cjn.02260409
  52. Verdoia M, Schaffer A, Sartori C, et al. Vitamin D deficiency is independently associated with the extent of coronary artery disease. Eur J Clin Invest. 2014;44:634-42. https://doi.org/10.1111/eci.12281
  53. Пигарова Е.А., Рожинская Л.Я., Белая Ж.Е., Дзеранова Л.К., Каронова Т.Л., Ильин А.В., Мельниченко Г.А., Дедов И.И. Клинические рекомендации Российской ассоциации эндокринологов по диагностике, лечению и профилактике дефицита витамина D у взрослых. Проблемы эндокринологии. 2016;4:60-84. https://doi.org/10.14341/probl201662460-84

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