Renal denervation with a resistant arterial hypertension: the results of a five-year follow-up


Cite item

Full Text

Abstract

Aim. To evaluate the 5-year results of renal denervation (RDN) in patients with resistant arterial hypertension (AH). Materials and methods. The study included 14 patients to whom, during the 2011-2013 period RDN has been completed. Before and after the intervention, office blood pressure, quality of life indicators according to the EQ-5D questionnaire, mass index bodies, indicators of kidney function were duly assessed. Results. Five years after RDN, office BP decreased from 165/110 to 139/95 mm Hg. Art. (p<0.05), with the average number of of drugs decreased from 4.6 to 3.1. 12 months after the RDA, the quality of Life, based on the questionnaire EQ-5D has increased from 60 to 80 points, by the fifth year the indicator fell to 74 points. Body mass index during 5 years decreased from 33.8 ± 3.5 to 30.9 ± 3.0 kg/m2. Mean plasma creatinine initially and after 5 years remained within the normal range, the mean the GFR score after 5 years being decreased by 9.5 ml/min/1.73 m2. Conclusion. RDN can be regarded as effective and safe method of additional treatment of patients with resistant hypertension.

About the authors

P V Glybochko

Scientific Research Institute of Human Morphology and Reproductive Health, Department of faculty therapy number 1 of the Faculty of Medicine, Federal state autonomous educational institution of higher professional education I.M.Sechenov First Moscow State Medical University (Sechenov University)

д.м.н., проф., акад. РАН, ректор, директор НИИ уронефрологии и репродуктивного здоровья человека Moscow, Russia

A A Svetankova

Scientific Research Institute of Human Morphology and Reproductive Health, Department of faculty therapy number 1 of the Faculty of Medicine, Federal state autonomous educational institution of higher professional education I.M.Sechenov First Moscow State Medical University (Sechenov University)

аспирант каф. фак. терапии №1 лечебного фак-та Moscow, Russia

A V Rodionov

Scientific Research Institute of Human Morphology and Reproductive Health, Department of faculty therapy number 1 of the Faculty of Medicine, Federal state autonomous educational institution of higher professional education I.M.Sechenov First Moscow State Medical University (Sechenov University)

к.м.н., доцент каф. фак. терапии №1 лечебного фак-та Moscow, Russia

A S Maltseva

Scientific Research Institute of Human Morphology and Reproductive Health, Department of faculty therapy number 1 of the Faculty of Medicine, Federal state autonomous educational institution of higher professional education I.M.Sechenov First Moscow State Medical University (Sechenov University)

студентка международной школы «Медицина будущего» ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России (Сеченовский университет) Moscow, Russia

V A Sulimov

Scientific Research Institute of Human Morphology and Reproductive Health, Department of faculty therapy number 1 of the Faculty of Medicine, Federal state autonomous educational institution of higher professional education I.M.Sechenov First Moscow State Medical University (Sechenov University)

д.м.н., проф., зав. каф. фак. терапии №1 лечебного фак-та ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России (Сеченовский университет) Moscow, Russia

V V Fomin

Scientific Research Institute of Human Morphology and Reproductive Health, Department of faculty therapy number 1 of the Faculty of Medicine, Federal state autonomous educational institution of higher professional education I.M.Sechenov First Moscow State Medical University (Sechenov University)

Email: fomin_vic@mail.ru
д.м.н., проф., член-корр. РАН, проректор по научно-исследовательской и клинической работе, зав. каф. фак. терапии; ORCID 0000-0002-2682-4417 Moscow, Russia

References

  1. Schlaich M, Sobotka P, Krum H, et al. Renal denervation as a therapeutic approach for hypertension: novel implications for an old concept. Hypertension. 2009;54:1195-201.
  2. Esler M.D, Krum H, Schlaich M, et al. Renal Sympathetic Denervation for Treatment of Drug-Resistant Hypertension. One-Year Results From the Symplicity HTN-2 Randomized, Controlled Trial. Circulation. 2012;126:2979-82.
  3. Bhatt D.L, Kandzari D.E, O'Neill W.W, et al. A controlled trial of renal denervation for resistant hypertension. N Engl J Med. 2014;370:1393-401.
  4. Kandzari D.E, Bhatt D.L, Brar S, et al. Predictors of blood pressure response in the Symplcity HTN-3 trial. Eur Heart J. 2015;36:219-27.
  5. Townsend R.R, Mahfoud F, Kandzari D.E, et al. Catheter - based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised, sham - controlled, proof - of - concept trial. Lancet. 2017 Nov 11;390(10108):2160-70.
  6. Kandzari D.E, Böhm M, Mahfoud F, et al. Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial. Lancet. 2018;391(10137):2346-55. doi: https://doi.org/10.1016/S0140-6736(18)30951-6.
  7. Сулимов В.А., Родионов А.В., Светанкова А.А. Ренальная денервация в лечении резистентной артериальной гипертензии: результаты одногодичного наблюдения. Рациональная фармакотерапия в кардиологии. 2015;11(3):304-8.
  8. Böhm M, Mancia G, Schmieder R, et al. Global SYMPLICITY Registry: 3 Year Safety and Efficacy Data Hypertension. 2017;70:A092.
  9. Зюбанова И.В., Мордовин В.Ф., Фальковская А.Ю., Пекарский С.Е. Изменения показателей суточного мониторирования артериального давления под влиянием ренальной денервации в течение 12-месячного наблюдения. Сибирский медицинский журнал (Томск). 2015;3:44-8.
  10. Мусаев А.А., Арипов М.А., Алимбаев С.А. и др. Влияние ренальной денервации на качество жизни пациентов с резистентной артериальной гипертензией. Вестник Казахского Национального медицинского университета. 2015;4:86-7.
  11. Glassock R.J, Winearls C. Ageing and the Glomerular Filtration Rate: Truths and Consequences. Transactions of the American Clinical and Climatological Association. Trans Amer Clin Climatol Ass. 2009;120:419-28.
  12. Williams B, Mancia G, et al. J Hypertens. 2018 and Eur Heart J 2018, in press.

Copyright (c) 2018 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies