Vitamin D: effects on pregnancy, maternal, fetal and postnatal outcomes


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Abstract

A high prevalence of vitamin D deficiency and its negative consequences for health is identified as area of primary concern for scientists and clinicians worldwide. Vitamin D deficiency affects not only bone health but many socially significant acute and chronic diseases. Observational studies support that pregnant and lactating women, children and teenagers represent the high risk groups for developing vitamin D deficiency. Current evidence highlights a crucial role of vitamin D in providing the fetal life-support system and fetus development, including implantation, placental formation, intra - and postpartum periods. Hypovitaminosis D during pregnancy is associated with a higher incidence of placental insufficiency, spontaneous abortions and preterm birth, preeclampsia, gestational diabetes, impaired fetal and childhood growth, increased risk of autoimmune diseases for offsprings. Potential mechanisms for the observed associations contain metabolic, immunomodulatory and antiinflammatory effects of vitamin D. Epigenetic modifications in vitamin D-associated genes and fetal programming are of particular interest. The concept of preventing vitamin D deficiency is actively discussed, including supplementation in different ethnic groups, required doses, time of initiation and therapy duration, influence on gestation and childbirth. An adequate supply of vitamin D during pregnancy improves the maternal and fetal outcomes, short and long term health of the offspring. Still current data on relationship between maternal vitamin D status and pregnancy outcomes remains controversial. The large observational and interventional randomized control trials are required to create evidence-based guidelines for the supplementation of vitamin D in pregnant and lactating women.

About the authors

A K Eremkina

National Endocrinology Research Center, Ministry of Health of Russia

Email: parathyroid.enc@gmail.com
к.м.н., с.н.с. отд-ния патологии околощитовидных желез Moscow, Russia

N G Mokrysheva

National Endocrinology Research Center, Ministry of Health of Russia

д.м.н., проф., зав. отд-нием патологии околощитовидных желез Moscow, Russia

E A Pigarova

National Endocrinology Research Center, Ministry of Health of Russia

к.м.н., в.н.с. отд-ния нейроэндокринологии и остеопатий Moscow, Russia

S S Mirnaya

National Endocrinology Research Center, Ministry of Health of Russia

к.м.н., н.с. отд-ния патологии околощитовидных желез Moscow, Russia

References

  1. Пигарова Е.А., Рожинская Л.Я., Белая Ж.Е., Дзеранова Л.К., Каронова Т.Л., Ильин А.В., Мельниченко Г.А., Дедов И.И. Клинические рекомендации Российской ассоциации эндокринологов по диагностике, лечению и профилактике дефицита витамина D у взрослых. Проблемы эндокринологии. 2016;62(4):60-84. doi: 10.14341/probl201662460-84
  2. Saraf R, Morton S.M.B, Camargo C.A, Grant C.C. Global summary of maternal and newborn vitamin D status - a systematic review. Matern Child Nutr. 2016;12:647-668. doi: 10.1111/mcn.12210
  3. Kaushal M, Magon N. Vitamin D in pregnancy: A metabolic outlook. Indian J Endocrinol Metab. 2013;17(1):76-82. doi: 10.4103/2230-8210.107862
  4. Bikle D.D. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014;21(3):319-329. doi: 10.1016/j.chembiol.2013.12.016
  5. Jäpelt R.B, Jakobsen J. Vitamin D in plants: a review of occurrence, analysis, and biosynthesis. Front Plant Sci. 2013;4:136. doi: 10.3389/fpls.2013.00136
  6. Wimalawansa S.J. Vitamin D; What clinicians would like to know. Sri Lanka J Diabetes Endocrinol Metab. 2012;1(2):73-80. doi: 10.4038/sjdem.v2i2.4776
  7. Palermo N.E, Holick M.F. Vitamin D, bone health, and other health benefits in pediatric patients. J Pediatr Rehabil Med. 2014;7:179-192. doi: 10.3233/PRM-140287
  8. Haussler M.R, Haussler C.A, Jurutka P.W, Thompson P.D, Hsieh J.C, Remus L.S, Selznick S.H, Whitfield G.K. The vitamin D hormone and its nuclear receptor: molecular actions and disease states. J Endocrinol. 1997;154 Suppl:S57-73.
  9. Zehnder D, Bland R, Williams M.C, et al. Extrarenal expression of 25-hydroxyvitamin D3-1alphahydroxylase. J Clin Endocr Metab. 2001;86(2):888-894. doi: 10.1210/jcem.86.2.7220
  10. Hollis B.W, Wagner C.L. Nutritional vitamin D status during pregnancy: reasons for concern. CMAJ. 2006;174:1287-1290. doi: 10.1503/cmaj.060149
  11. Hollis B.W, Wagner C.L. Vitamin D supplementation during pregnancy: Improvements in birth outcomes and complications through direct genomic alteration. Mol Cell Endocrinol. 2017;453:113-130. doi: 10.1016/j.mce.2017.01.039
  12. Ginde A.A, Sullivan A.F, Mansbach J.M, Camargo C.A. Vitamin D insufficiency in pregnant and nonpregnant women of childbearing age in the United States. Am J Obstet Gynecol. 2010;202:436.e1-8. doi: 10.1016/j.ajog.2009.11.036
  13. Karras S, Paschou S.A, Kandaraki E, Anagnostis P, Annweiler C, Tarlatzis B.C, Hollis B.W, Grant W.B, Goulis D.G. Hypovitaminosis D in pregnancy in the Mediterranean region: a systematic review. Eur J Clin Nutr. 2016 Sep;70(9):979-986. doi: 10.1038/ejcn.2016.12
  14. Мокрышева Н.Г., Липатенкова А.К., Таллер Н.А. Первичный гиперпаратиреоз и беременность. Акушерство и гинекология. 2016;(10):18-25. doi: 10.18565/aig.2016.10.18-25
  15. Møller U.K, Streym S, Mosekilde L, Heickendorff L, Flyvbjerg A, Frystyk J, Jensen L.T, Rejnmark L. Changes in calcitropic hormones, bone markers and insulin - like growth factor I (IGF-I) during pregnancy and postpartum: a controlled cohort study. Osteoporos Int. 2013;24:1307-1320. doi: 10.1007/s00198-012-2062-2
  16. Kovacs C.S, Kronenberg H.M. Maternal-Fetal Calcium and Bone Metabolism During Pregnancy, Puerperium, and Lactation. Endocr Rev. 1997;18:832-872. doi: 10.1210/edrv.18.6.0319
  17. Gray T.K, Lester G.E, Lorenc R.S. Evidence for extra - renal 1 alpha - hydroxylation of 25-hydroxyvitamin D3 in pregnancy. Science. 1979;204:1311-1313.
  18. Hollis B.W, Wagner C.L. Vitamin D and pregnancy: skeletal effects, nonskeletal effects, and birth outcomes. Calcif Tissue Int. 2013;92:128-139. doi: 10.1007/s00223-012-9607-4
  19. Kovacs C.S. Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery. Physiol Rev. 2016;96:449-547. doi: 10.1152/physrev.00027.2015
  20. Zhong Y, Armbrecht H.J, Christakos S. Calcitonin, a regulator of the 25-hydroxyvitamin D3 1alpha - hydroxylase gene. J Biol Chem. 2009;284:11059-11069. doi: 10.1074/jbc.M806561200
  21. Weisman Y, Harell A, Edelstein S, David M, Spirer Z, Golander A. 1 alpha, 25-Dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 in vitro synthesis by human decidua and placenta. Nature. 1979;281:317-319.
  22. Novakovic B, Sibson M, Ng H.K, Manuelpillai U, Rakyan V, Down T, Beck S, Fournier T, Evain-Brion D, Dimitriadis E, Craig J.M, Morley R, Saffery R. Placenta - specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. J Biol Chem. 2009;284:14838-14848. doi: 10.1074/jbc.M809542200
  23. Adams J.S, Hewison M. Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase. Arch Biochem Biophys. 2012;523:95-102. doi: 10.1016/j.abb.2012.02.016
  24. Noff D, Edelstein S. Vitamin D and its hydroxylated metabolites in the rat. Placental and lacteal transport, subsequent metabolic pathways and tissue distribution. Horm Res. 1978;9:292-300.
  25. Hossein-nezhad A, Holick M.F. Vitamin D for health: a global perspective. Mayo Clin Proc. 2013 Jul;88(7):720-755. doi: 10.1016/j.mayocp.2013.05.011
  26. Young B.E, Cooper E.M, Mc Intyre A.W, Kent T, Witter F, Harris Z.L, O’Brien K.O. Placental vitamin D receptor (VDR) expression is related to neonatal vitamin D status, placental calcium transfer, and fetal bone length in pregnant adolescents. FASEB J. 2014;28:2029-2037. doi: 10.1096/fj.13-246736
  27. Wuertz C, Gilbert P, Baier W, Kunz C. Cross - sectional study of factors that influence the 25-hydroxyvitamin D status in pregnant women and in cord blood in Germany. Br J Nutr. 2013;110:1895-1902. doi: 10.1017/S0007114513001438
  28. Reichetzeder C, Dwi Putra S.E, Li J, Hocher B. Developmental Origins of Disease - Crisis Precipitates Change. Cell Physiol Biochem. 2016;39:919-938. doi: 10.1159/000447801
  29. Fetahu I.S, Höbaus J, Kállay E. Vitamin D and the epigenome. Front Physiol. 2014;5. doi: 10.3389/fphys.2014.0
  30. Barker D.J, Eriksson J.G, Forsen T, Osmond C. Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol. 2002;31(6):1235-1239.
  31. Morris G.S, Zhou Q, Hegsted M, Keenan M.J. Maternal consumption of a low vitamin D diet retards metabolic and contractile development in the neonatal rat heart. J Mol Cell Cardiol. 1995;27(6):1245-1250.
  32. Maka N, Makrakis J, Parkington H.C, Tare M, Morley R, Black M.J. Vitamin D deficiency during pregnancy and lactation stimulates nephrogenesis in rat offspring. Pediatr Nephrol. 2008;23(1):55-61. doi: 10.1007/s00467-007-0641-9
  33. Xue J, Schoenroc S.A, Valdar K.W, Tarantino L.M, Ideraabdullah F.Y. Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations. Clin Epigenetics. 2016;8:107. doi: 10.1186/s13148-016-0276-4
  34. Junge K.M, Bauer T, Geissler S, Hirche F, Thurmann L, Bauer M, Trump S, Bieg M, Weichenhan D, Gu L, et al. Increased vitamin D levels at birth and in early infancy increase offspring allergy risk - evidence for involvement of epigenetic mechanisms. J Allergy Clin Immunol. 2015;137:610-613. doi: 10.1016/j.jaci.2015.06.040
  35. Suderman M, Stene L.C, Bohlin J, Page C.M, Holvik K, Parr C.L, Magnus M.C, Håberg S.E, Joubert B.R, Wu M.C, London S.J, Relton C, Nystad W. 25-Hydroxyvitamin D in pregnancy and genome wide cord blood DNA methylation in two pregnancy cohorts (MoBa and ALSPAC). J Steroid Biochem Mol Biol. 2016;159:102-109. doi: 10.1016/j.jsbmb.2016.03.005
  36. Hossein-nezhad A, Spira A, Holick M.F. Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double - blind clinical trial. PLoS One. 2013;8(3):e58725. doi: 10.1371/journal.pone.0058725
  37. Zhou Y, Zhao L.J, Xu X, Ye A, Travers-Gustafson D, Zhou B, Wang H-W, Zhang W, Lee Hamm L, Deng H-W, Recker R.R, Lappe J.M. DNA methylation levels of CYP2R1 and CYP24A1 predict vitamin D response variation. J Steroid Biochem Mol Biol. 2014;144 Pt A:207-214. doi: 10.1016/j.jsbmb.2013.10.004
  38. Bärebring L, Schoenmakers I, Glantz A, Hulthén L, Jagner Å, Ellis J, Bärebring M, Bullarbo M, Augustin H, Vitamin D. Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort. Nutrients. 2016;8. doi: 10.3390/nu8100655
  39. Crozier S.R, Harvey N.C, Inskip H.M, Godfrey K.M, Cooper C, Robinson S.M, the S.S. Group. Maternal vitamin D status in pregnancy is associated with adiposity in the offspring: findings from the Southampton Women’s Survey. Am J Clin Nutr. 2012;96:57-63. doi: 10.3945/ajcn.112.037473
  40. Vinkhuyzen A, Eyles D, Burne T, Blanken L, Kruithof C, Verhulst F, et al. Prevalence and predictors of vitamin D deficiency based on maternal mid - gestation and neonatal cord bloods: the Generation R Study. J Steroid Biochem Mol Biol. 2015. doi: 10.1016/j.jsbmb.2015.09.018
  41. Perampalam S, Ganda K, Chow K-A, Opie N, Hickman P.E, Shadbolt B, Hennessy A, Grunstein H, Nolan C.J. Vitamin D status and its predictive factors in pregnancy in 2 Australian populations. Aust N Z J Obstet Gynaecol. 2011;51:353-359. doi: 10.1111/j.1479-828X.2011.01313.x
  42. Nobles C.J, Markenson G, Chasan-Taber L. Early pregnancy vitamin D status and risk for adverse maternal and infant outcomes in a bi - ethnic cohort: the Behaviors Affecting Baby and You (B.A.B.Y.) Study. Br J Nutr. 2015;215:2116-2128. doi: 10.1017/S0007114515003980
  43. Haggarty P, Campbell D, Knox S, Horgan G, Hoad G, Boulton E, et al. Vitamin D in pregnancy at high latitude in Scotland. Br J Nutr. 2013;109:898-905. doi: 10.1017/S0007114512002255
  44. Mcgrath J, Eyles D, Pedersen C, Anderson C, Ko P, Burne T, et al. (2010) Neonatal vitamin D status and risk of schizophrenia: a population - based case - control study. Arch Gen Psychiatry. 2010;67:889-894. doi: 10.1001/archgenpsychiatry.2010.110
  45. Day F, Forouhi N, Ong K, Perry J. (2015) Season of birth is associated with birth weight, pubertal timing, adult body size and educational attainment: a UK Biobank study. Heliyon. 2015;1:e00031. doi: 10.1016/j.heliyon.2015.e00031
  46. Wagner C.L, Greer F.R, American Academy of Pediatrics Section on B, American Academy of Pediatrics Committee on N. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008;122(5):1142-1152. doi: 10.1542/peds.2008-1862
  47. Gernand A.D, Bodnar L.M, Klebanoff M.A, Parks W.T, Simhan H.N. Maternal serum 25-hydroxyvitamin D and placental vascular pathology in a multicenter US cohort. Am J Clin Nutr. 2013;98(2):383-388.
  48. Murthi P, Yong H.E, Ngyuen T.P, Ellery S, Singh H, Rahman R, et al. Role of the Placental Vitamin D Receptor in Modulating Feto-Placental Growth in Fetal Growth Restriction and Preeclampsia-Affected Pregnancies. Front Physiol. 2016;7:43. doi: 10.3389/fphys.2016.00043
  49. Evans K.N, Bulmer J.N, Kilby M.D, Hewison M. Vitamin D and placental - decidual function. J Soc Gynecol Investig. 2004;11:263-271. doi: 10.1016/j.jsgi.2004.02.002
  50. Barrera D, Avila E, Hernández G, Halhali A, Biruete B, Larrea F, Díaz L. Estradiol and progesterone synthesis in human placenta is stimulated by calcitriol. J Steroid Biochem Mol Biol. 2007;103:529-532. doi: 10.1016/j.jsbmb.2006.12.097
  51. Du H, Daftary G.S, Lalwani S.I, Taylor H.S. Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells. Mol Endocrinol. 2005 Sep;19(9):2222-2233. doi: 10.1210/me.2004-0336
  52. Liu N.Q, Kaplan A.T, Lagishetty V, Ouyang Y.B, Ouyang Y, Simmons C.F, et al. Vitamin D and the regulation of placental inflammation. J Immunol. 2011;186(10):5968-5974. doi: 10.4049/jimmunol.1003332
  53. Пигарова Е.А., Плещева А.В., Дзеранова Л.К. Влияние витамина D на иммунную систему. Иммунология. 2015;(1):62-66.
  54. Barrera D, Avila E, Hernández G, Méndez I, González L, Halhali A, Larrea F, Morales A, Díaz L. Calcitriol affects hCG gene transcription in cultured human. Reprod Biol Endocrinol. 2008 Jan 22;6:3. doi: 10.1186/1477-7827-6-3
  55. Díaz L, Noyolaartínez N, Barrera D, Hernández G, Avila E, Halhali A, Larrea F. Calcitriol inhibits TNF-alpha - induced inflammatory cytokines in human trophoblasts. J Reprod Immunol. 2009;81:17-24. doi: 10.1016/j.jri.2009.02.005
  56. Rolle L, Memarzadeh Tehran M, Morell-García A, Raeva Y, Schumacher A, Hartig R, Costa S.D, Jensen F, Zenclussen A.C. Cutting edge: IL-10-producing regulatory B cells in early human pregnancy. Am J Reprod Immunol. 2013 Dec;70(6):448-453. doi: 10.1111/aji.12157
  57. Grayson R, Hawison, M. Vitamin D and human pregnancy. Fetal Maternal Med Rev. 2011;22(1):67-90. doi: 10.1017/S0965539511000039
  58. Selvaraj P. Vitamin D, vitamin D receptor, and cathelicidin in the treatment of tuberculosis. Vitam Horm. 2011;86:307-25. doi: 10.1016/B978-0-12-386960-9.00013-7
  59. Van Oostrum N, De Sutter P, Meys J, Verstraelen H. Risks associated with bacterial vaginosis in infertility patients: a systematic review and meta - analysis. Hum Reprod. 2013;28(7):1809-1815. doi: 10.1093/humrep/det096
  60. Christesen H.T, Falkenberg T, Lamont R.F, Jorgensen J.S. The impact of vitamin D on pregnancy: a systematic review. Acta Obstet Gynecol Scand. 2012;91(12):1357-1367. doi: 10.1111/aogs.12006
  61. Сидорова И.С. Решенные вопросы и нерешенные проблемы преэклампсии в России. Российский вестник акушера - гинеколога. 2015;15(2):4. doi: 10.17116/rosakush20151524-9
  62. Ghulmiyyah L, Sibai В. Maternal mortality from preeclampsia/eclampsia. Semin Perinatol. 2012 Feb;36(1):56-59. doi: 10.1053/j.semperi.2011.09.011
  63. Hypponen E. Vitamin D for the prevention of preeclampsia? A hypothesis. Nutr Rev. 2005;63(7):225-232. doi: 10.1301/nr.2005.jul.225-232
  64. Girardi G, Yarilin D, Thurman J.M, Holers V.M, Salmon J.E. Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J Exp Med. 2006 Sep 4;203(9):2165-2175. doi: 10.1084/jem.20061022
  65. Romero R, Nien J.K, Espinoza J, Todem D, Fu W, Chung H, Kusanovic J.P, Gotsch F, Erez O, Mazaki-Tovi S, Gomez R, Edwin S, Chaiworapongsa T, Levine R.J, Karumanchi S.A. A longitudinal study of angiogenic (placental growth factor) and anti - angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Neonatal Med. 2008 Jan;21(1):9-23. doi: 10.1080/14767050701830480
  66. Mulligan M.L, Felton S.K, Riek A.E, Bernal-Mizrachi C. Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol. 2010;202(5):429 e1-9. doi: 10.1016/j.ajog.2009.09.002
  67. Mirzakhani H, Litonjua A.A, Mc Elrath T.F, O'Connor G, Lee-Parritz A, Iverson R, et al. Early pregnancy vitamin D status and risk of preeclampsia. J Clin Invest. 2016;126(12):4702-4715. doi: 10.1172/JCI89031
  68. Pérez-López R, Pasupuleti V, Mezones-Holguin E, Benites-Zapata V.A, Thota P, Deshpande A, Hernandez A.V. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta - analysis of randomized controlled trials. Fertil Steril. 2015;103:1278-1288.e4. doi: 10.1016/j.fertnstert.2015.02.019
  69. Boyle V.T, Thorstensen E.B, Mourath D, Jones M.B, Mc Cowan L.M.E, Kenny L.C, Baker P.N. The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort. Br J Nutr. 2016;116:1409-1415. doi: 10.1017/S0007114516003202
  70. De-Regil L.M, Palacios C, Lombardo L.K, Peña-Rosas J.P. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2016;1:CD008873. doi: 10.1002/14651858.CD008873.pub3
  71. Robinson C.J, Alanis M.C, Wagner C.L, Hollis B.W, Johnson D.D. Plasma 25-hydroxy vitamin D levels in early - onset severe preeclampsia. Am J Obstet Gynecol. 2010;203:e361-e366.
  72. Wagner C.L, Mc Neil R, Hamilton S.A, Winkler J, Rodriguez Cook C, Warner G, Bivens B, Davis D.J, Smith P.G, Murphy M, Shary J.R, Hollis B.W. A randomized trial of vitamin D supplementation in 2 community health center networks in South Carolina. Am J Obstet Gynecol. 2013;208137.e1-13. doi: 10.1016/j.ajog.2012.10.888
  73. Li N, Wu H.M, Hang F, Zhang Y.S, Li M.J. Women with recurrent spontaneous abortion have decreased 25(OH) vitamin D and VDR at the fetal - maternal interface. Brazil J Med Biol Res. 2017;50(11):e6527. doi: 10.1590/1414-431X20176527
  74. Vijayendra C.A, Hemalatha R, Seshacharyulu M, Vasudeva M.M, Jayaprakash D, Dinesh K.B. Vitamin D deficiency in pregnant women impairs regulatory T cell function. J Steroid Biochem Mol Biol. 2014;147:48-55. doi: 10.1016/j.jsbmb.2014.11.020
  75. Hamzaoui A, Berraïes A, Hamdi B, Kaabachi W, Ammar J, Hamzaoui K. Vitamin D reduces the differentiation and expansion of Th17 cells in young asthmatic children. Immunobiology. 2014;219:873-879. doi: 10.1016/j.imbio.2014.07.009
  76. Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev. 2016;96:365-408. doi: 10.1152/physrev.00014.2015
  77. Taheri M, Baheiraei A, Foroushani A.R, Nikmanesh B, Modarres M. Treatment of vitamin D deficiency is an effective method in the elimination of asymptomatic bacterial vaginosis: A placebo - controlled randomized clinical trial. Indian J Med Res. 2015 Jun;141(6):799-806. doi: 10.4103/0971-5916.160707
  78. Hollis B.W, Johnson D, Hulsey T.C, Ebeling M, Wagner C.L. Vitamin D supplementation during pregnancy: double - blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res. 2011;26(10):2341-2357. doi: 10.1002/jbmr.463
  79. Gernand A.D, Klebanoff M.A, Simhan H.N, Bodnar L.M. Maternal vitamin D status, prolonged labor, cesarean delivery and instrumental delivery in an era with a low cesarean rate. J Perinatol. 2015;35:23-28. doi: 10.1038/jp.2014.139
  80. Merewood A, Mehta S.D, Chen T.C, Bauchner H, Holick M.F. Association between Vitamin D Deficiency and Primary Cesarean Section. J Clin Endocrinol Metab. 2009;94:940-945. doi: 10.1210/jc.2008-1217
  81. Savvidou M.D, Makgoba M, Castro P.T, Akolekar R, Nicolaides K.H. First - trimester maternal serum vitamin D and mode of delivery. Br J Nutr. 2012;108:1972-1975. doi: 10.1017/S0007114512000207
  82. Scholl T.O, Chen X, Stein P. Maternal Vitamin D Status and Delivery by Cesarean. Nutrients. 2012;4:319-330. doi: 10.3390/nu4040319
  83. Cho N.H. IDF Diabetes Atlas. 7th ed. Brussels: International Diabetes Federation; 2015.
  84. Burris H.H, Camargo C.A.Jr. Vitamin D and gestational diabetes mellitus. Curr Diab Rep. 2014;14(1):451. doi: 10.1007/s11892-013-0451-3
  85. Soheilykhah S, Mojibian M, Rashidi M, Rahimi-Saghand S, Jafari F. Maternal vitamin D status in gestational diabetes mellitus. Nutr Clin Pract. 2010;25(5):524-527. doi: 10.1177/0884533610379851
  86. Pittas A.G, Lau J, Hu F.B, et al. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta - analysis. J Clin Endocrinol Metab. 2007;92:2017-2029. doi: 10.1210/jc.2007-0298
  87. Wei S.Q, Qi H.P, Luo Z.C, Fraser W.D. Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta - analysis. J Matern Fetal Neonatal Med. 2013 Jun;26(9):889-899. doi: 10.3109/14767058.2013.765849
  88. Poel Y.H, Hummel P, Lips P et al. Vitamin D and gestational diabetes: a systematic review and meta - analysis. Eur J Intern Med. 2012 Jul;23(5):465-469. doi: 10.1016/j.ejim.2012.01.007
  89. Lu M, Xu Y, Lv L, Zhang M. Association between vitamin D status and the risk of gestational diabetes mellitus: a meta - analysis. Arch Gynecol Obstet. 2016. doi: 10.1007/s00404-016-4010-4
  90. Zhou J, Su L, Liu M, Liu Y, Cao X, Wang Z, Xiao H. Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China. Eur J Clin Nutr. 2014;68:925-930. doi: 10.1038/ejcn.2014.99
  91. Soheilykhah S, Mojibian M, Moghadam M.J, Shojaoddiny-Ardekani A. The effect of different doses of vitamin D supplementation on insulin resistance during pregnancy. Gynecol Endocrinol. 2013;29(4):396-399. doi: 10.3109/09513590.2012.752456
  92. Yap C, Cheung N.W, Gunton J.E et al. Vitamin D supplementation and the effects on glucose metabolism during pregnancy: a randomized controlled trial. Diabetes Care. 2014 Jul;37(7):1837-1844. doi: 10.2337/dc14-0155
  93. Akbari M, Mosazadeh M, Lankarani K.B, Tabrizi R, Samimi M, Karamali M, Jamilian M, Kolahdooz F, Asemi Z. The Effects of Vitamin D Supplementation on Glucose Metabolism and Lipid Profiles in Patients with Gestational Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Horm Metab Res. 2017 Sep;49(9):647-653. doi: 10.1055/s-0043-115225
  94. Curtis E.M, Moon R.J, Dennison E.M, Harvey N.C. Prenatal calcium and vitamin D intake, and bone mass in later life. Curr Osteoporos Rep. 2014;12:194-204. doi: 10.1007/s11914-014-0210-7
  95. Glazier D, Mawer E.B, Sibley C.P, Calbindin-D9K gene expression in rat chorioallantoic placenta is not regulated by 1,25-dihydroxyvitamin D3. Pediatr Res. 1995;37:720-725. doi: 10.1203/00006450-199506000-00008
  96. Kovacs C.S, Woodland M.L, Fudge N.J, Friel J.K. The vitamin D receptor is not required for fetal mineral homeostasis or for the regulation of placental calcium transfer in mice. Am J Physiol Endocrinol Metab. 2005;289:E133-144. doi: 10.1152/ajpendo.00354.2004
  97. Javaid M.K, Crozier S.R, Harvey N.C, Gale C.R, Dennison E.M, Boucher B.J, Arden N.K, Godfrey K.M, Cooper C. Princess Anne Hospital Study Group, Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet. 2006;367:36-43. doi: 10.1016/S0140-6736(06)67922-1
  98. Lawlor D.A, Wills A.K, Fraser A, Sayers A, Fraser W.D, Tobias J.H. Association of maternal vitamin D status during pregnancy with bone - mineral content in offspring: a prospective cohort study. Lancet. 2013;381:2176-2183. doi: 10.1016/S0140-6736(12)62203-X
  99. Cooper C, Harvey N.C, Bishop N.J, Kennedy S, Papageorghiou A.T, Schoenmakers I, Fraser R, Gandhi S.V, Carr A, D’Angelo S, Crozier S.R, Moon R.J, et al. Maternal gestational vitamin D supplementation and offspring bone health (MAVIDOS): a multicentre, double - blind, randomised placebo - controlled trial. Lancet Diabetes Endocrin. 2016;4(5):393-402. doi: 10.1016/S2213-8587(16)00044-9
  100. Miliku K, Vinkhuyzen A, Blanken L.M, Mc Grath J.J, Eyles D.W, Burne T.H, Hofman A, Tiemeier H, Steegers E.A, Gaillard R, Jaddoe V.W. Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes. Am J Clin Nutr. 2016. doi: 10.3945/ajcn.115.123752
  101. Chen Y-H, Fu L, Hao J-H, Yu Z, Zhu P, Wang H, Xu Y-Y, Zhang C, Tao F-B, Xu D-X. Maternal vitamin D deficiency during pregnancy elevates the risks of small for gestational age and low birth weight infants in Chinese population. J Clin Endocrinol Metab. 2015;100:1912-1919. doi: 10.1210/jc.2014-4407.J
  102. Tyrrell J, Richmond R.C, Palmer T.M, Feenstra B, Rangarajan J, Metrustry S, Cavadino A, Paternoster L, Armstrong L.L. Early Growth Genetics (EGG) Consortium, Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA. 2016;315:1129-1140. doi: 10.1001/jama.2016.1975
  103. Walsh J.M, Mc Gowan C.A, Kilbane M, Mc Kenna M.J, Mc Auliffe F.M. The Relationship Between Maternal and Fetal Vitamin D, Insulin Resistance, and Fetal Growth. Reprod Sci. 2013;20(5):536-541. doi: 10.1177/1933719112459222
  104. Leffelaar E.R, Vrijkotte T.G.M, van Eijsden M. Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: results of the multi - ethnic Amsterdam Born Children and their Development cohort. Br J Nutr. 2010;104:108-117. doi: 10.1017/S000711451000022X
  105. Marjamäki L, Niinistö S, Kenward M.G, Uusitalo L, Uusitalo U, Ovaskainen M-L, Kronberg-Kippilä C, Simell O, Veijola O.R, Ilonen J, Knip M, Virtanen S.M. Maternal intake of vitamin D during pregnancy and risk of advanced beta cell autoimmunity and type 1 diabetes in offspring. Diabetologia. 2010;53:1599-1607. doi: 10.1007/s00125-010-1734-8
  106. Stene L.C, Joner G. Norwegian Childhood Diabetes Study Group, Use of cod liver oil during the first year of life is associated with lower risk of childhood - onset type 1 diabetes: a large, population - based, case - control study. Am J Clin Nutr. 2003;78:1128-1134.
  107. Sørensen I.M, Joner G, Jenum P.A, Eskild A, Torjesen P.A, Stene L.C. Maternal serum levels of 25-hydroxyvitamin D during pregnancy and risk of type 1 diabetes in the offspring. Diabetes. 2012;61:175-178. doi: 10.2337/db11-0875
  108. Brekke H.K, Ludvigsson J. Vitamin D supplementation and diabetes - related autoimmunity in the ABIS study. Pediatr Diabetes. 2007;8:11-14. doi: 10.1111/j.1399-5448.2006.00223.x
  109. Hyppönen E, Läärä E, Reunanen A, Järvelin M.R, Virtanen S.M. Intake of vitamin D and risk of type 1 diabetes: a birth - cohort study. Lancet. 2001;358:1500-1503. doi: 10.1016/S0140-6736(01)06580-1
  110. Fronczak C.M, Barón A.E, Chase H.P, Ross C, Brady H.L, Hoffman M, Eisenbarth G.S, Rewers M, Norris J.M. In utero dietary exposures and risk of islet autoimmunity in children. Diabetes Care. 2003;26:3237-3242.
  111. Munger K.L, Åivo J, Hongell K, Soilu-Hänninen M, Surce H-M, Ascherio A. Vitamin D Status During Pregnancy and Risk of Multiple Sclerosis in Offspring of Women in the Finnish Maternity Cohort. JAMA Neurol. 2016;73:515-519. doi: 10.1001/jamaneurol.2015.4800
  112. Erkkola M, Kaila M, Nwarг B.I, Kronberg-Kippilä C, Ahonen S, Nevalainen J, Veijola R, Pekkanen J, Ilonen J, Simell O, Knip M, Virtanen S.M. Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year - old children. Clin Exp Allergy. 2009;39:875-882. doi: 10.1111/j.1365-2222.2009.03234.x
  113. Weisse K, Winkler S, Hirche F, Herberth G, Hinz D, Bauer M, Röder S, Rolle-Kampczyk U, von Bergen M, Olek S, Sack U, Richter T, Diez U, Borte M, Stangl G.I, Lehmann I. Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study. Allergy. 2013;68:220-228. doi: 10.1111/all.12081
  114. Zosky G.R, Hart P.H, Whitehouse A.J.O, et al. Vitamin D deficiency at 16 to 20 weeks’ gestation is associated with impaired lung function and asthma at 6 years of age. Ann Am Thorac Soc. 2014;11(4):571-577. doi: 10.1513/AnnalsATS.201312-423OCPMID: 24601713
  115. Camargo C.A. Jr, Ingham T, Wickens K, et al. Cord - blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics. 2011;127(1): e180-e187. doi: 10.1542/peds.2010-0442
  116. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010;91(5):1255-1260. doi: 10.3945/ajcn.2009.29094
  117. Levenson C.W, Figueirôa S.M. Gestational vitamin D deficiency: long - term effects on the brain. Nutr Rev. 2008;66:726-729. doi: 10.1111/j.1753-4887.2008.00122.x
  118. Eyles D, Brown J, Mackay-Sim A, et al. Vitamin D3 and brain development. Neuroscience. 2003;118:641-653. doi: 10.1016/s0306-4522(03)00040-x
  119. Grant W.B, Soles C.M. Epidemiologic evidence supporting the role of maternal vitamin D deficiency as a risk factor for the development of infantile autism. Dermatoendocrinology. 2009;1:223-228.
  120. Stubbs G, Henley K, Green J. Autism: Will vitamin D supplementation during pregnancy and early childhood reduce the recurrence rate of autism in newborn siblings? Med Hypotheses. 2016;88:74-78. doi: 10.1016/j.mehy.2016.01.015
  121. N. and A. (NDA) EFSA Panel on Dietetic Products, Dietary reference values for vitamin D. EFSA J. 2016;14:n/a-n/a. doi: 10.2903/j.efsa.2016.4547
  122. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, Dietary Reference Intakes for Calcium and Vitamin D. Washington (DC): National Academies Press (US); 2011.
  123. Munns C.F, Shaw N, Kiely M, Specker B.L, Thacher T.D, Ozono K, Michigami T, Tiosano D, et al. Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. J Clin Endocrinol Metab. 2016;101:394-415. doi: 10.1210/jc.2015-2175
  124. Dawodu A, Saadi H.F, Bekdache G, Javed Y, Altaye M, Hollis B.W. Randomized controlled trial (RCT) of vitamin D supplementation in pregnancy in a population with endemic vitamin D deficiency. J Clin Endocrinol Metab. 2013;98:2337-2346. doi: 10.1210/jc.2013-1154
  125. Grant C.C, Stewart A.W, Scragg R, Milne T, Rowden J, Ekeroma A, Wall C, Mitchell E.A, Crengle S, Trenholme A, Crane J, Camargo C.A. Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration. Pediatrics. 2014;133:e143-153. doi: 10.1542/peds.2013-2602

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