From Schönlein-Henoch purpura to IgA-vasculitis: pathogenetic aspects of the disease


Cite item

Full Text

Abstract

Investigation’s history and nomenclature’s evolution of the IgA-vasculitis are presented in the article. Pathogenesis of the renal and skin damages is discussed in details, particularly abnormalities of the IgA-immunity and systemic endotoxemia. Relevant world’s literature is cited.

About the authors

S V Guliaev

I.M. Sechenov First Moscow State Medical University Ministry of Health of Russia (Sechenov University)

Email: guldoc@mail.ru
к.м.н., доц. каф. внутренних, профессиональных болезней и ревматологии Moscow, Russia

L A Strizhakov

I.M. Sechenov First Moscow State Medical University Ministry of Health of Russia (Sechenov University)

д.м.н., проф. каф. внутренних, профессиональных болезней и ревматологии, руководитель Центра профессиональной патологии Минздрава России Moscow, Russia

S V Moiseev

I.M. Sechenov First Moscow State Medical University Ministry of Health of Russia (Sechenov University)

д.м.н., проф., зав. каф. внутренних, профессиональных болезней и ревматологии; директор клиники ревматологии, нефрологии и профпатологии им. Е.М. Тареева Moscow, Russia

V V Fomin

I.M. Sechenov First Moscow State Medical University Ministry of Health of Russia (Sechenov University)

член-корр. РАН, д.м.н., проф., проректор по лечебной работе, зав. каф. факультетской терапии №1, директор клиники факультетской терапии им. В.Н. Виноградова Moscow, Russia

References

  1. Heberden W. Commentaries on history and cure diseases. London; 1802.
  2. Schönlein J.L, in: Allgemeine und specielle Pathologie und Therapie. Vol. 2. 3rd ed. Wurzburg: Herisau; 1837. P. 48.
  3. Henoch E.H. Uber eine eigenthumbliche form von purpura. Berl Klin Wochnschr. 1874;11:641-643.
  4. Henoch E.H. Die hamorrhagische diathese - purpura. In: Vorlesungen uber Kinderkrankheiten. Berlin: Hirschwald; 1895. Bd 9. S. 847.
  5. Osler W. The Visceral Lesions of Purpura and Allied Conditions. Brit Med J. 1914;1:517.
  6. Frank E. Hamorrhagische Diathesen. In: Schittenhelm Handbuch der Krankheiten des Blutes und der blutbildenden Organe. Berlin: Springer; 1925.
  7. Jennette J.C, Falk R.J, Andrassy K, et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum. 1994 Feb;37(2):187-192.
  8. Насонова В.А. Геморрагический васкулит (Болезнь Шенлейна-Геноха). Москва: Медгиз; 1959. 175 с.
  9. Jennette J.C, Falk R.J, Bacon P.A. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65(1):1-11. doi: 10.1002/art.37715
  10. Berger J, Hinglais N. Les dépôts intercapillaires d'IgA-IgG. J Urol Nephrol. 1968;74:694-695.
  11. Kauffmann R.H, Herrmann W.A, Meÿer C.J, et al. Circulating IgA-immune complexes in Henoch-Schönlein purpura. A longitudinal study of their relationship to disease activity and vascular deposition of IgA. Am J Med. 1980;69(6):859-866.
  12. Pabst O. New concepts in the generation and functions of IgA. Nat Rev Immunol. 2012;12:821-832. doi: 10.1038/nri3322
  13. Jacob C.M, Pastorino A.C, Fahl K, et al. Autoimmunity in IgA deficiency: revisiting the role of IgA as a silent housekeeper. J Clin Immunol. 2008;28 Suppl 1:S56-61. doi: 10.1007/s10875-007-9163-2
  14. Novak J, Moldoveanu Z, Renfrow M.B. IgA nephropathy and Henoch-Schoenlein purpura nephritis: aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells. Contrib Nephrol. 2007;157:134-138. doi: 10.1159/000102455
  15. Heineke M.H, Ballering A.V, Jamin A. New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura). Autoimmun Rev. 2017;16(12):1246-1253. doi: 10.1016/j.autrev.2017.10.009
  16. Kokubo T, Hiki Y, Iwase H, Tanaka A, Toma K, Hotta K, Kobayashi Y. Protective role of IgA1 glycans against IgA1self - aggregation and adhesion to extracellular matrix proteins. J Am Soc Nephrol. 1998;9:2048-2054.
  17. Novak J, Julian B.A, Tomana M, et al. IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy. Semin Nephrol. 2008;28:78-87. doi: 10.1016/j.semnephrol.2007.10.009
  18. Davin J.C, Ten Berge I.J, Weening J.J. What is the difference between IgA nephropathy and Henoch-Schonlein purpura nephritis? Kidney Int. 2001;59:823-834. doi: 10.1046/j.1523-1755.2001.059003823.x
  19. Waldo F.B. Is Henoch-Schönlein purpura the systemic form of IgA nephropathy? Am J Kidney Dis. 1988;12(5):373-377.
  20. Smith A.C, Molyneux K, Feehally J, Barratt J. O-glycosylation of serum IgA1 antibodies against mucosal and systemic antigens in IgA nephropathy. J Am Soc Nephrol. 2006;17(12):3520-3528. doi: 10.1681/ASN.2006060658
  21. Launay P, Grossetete B, Arcos-Fajardo M, et al. Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-IgA complexes in patients and CD89 transgenic mice. J Exp Med. 2000;191:1999-2009.
  22. Haddad E, Moura I.C, Arcos-Fajardo M, Macher M.A, Baudouin V, Alberti C, Loirat C, Monteiro R.C, Peuchmaur M. Enhanced expression of the CD71 mesangial IgA1 receptor in Berger disease and Henoch-Schönlein nephritis: association between CD71 expression and IgA deposits. J Am Soc Nephrol. 2003;14:327-337.
  23. Wyatt R.J. The complement system in IgA nephropathy and Henoch-Schönlein purpura: functional and genetic aspects. Contrib Nephrology. 1993;104:82-91.
  24. Endo M, Ohi H, Ohsawa I, Fujita T, Matsushita M, Fujita T. Glomerular deposition of mannose - binding lectin (MBL) indicates a novel mechanism of complement activation in IgA-nephropathy. Nephrol Dial Transplant. 1998;13:1984-1990.
  25. Allen A.C, Willis F.R, Beattie T.J, Feehally J. Abnormal IgA glycosylation in Schönlein-Henoch purpura restricted to patients with clinical nephritis. Nephrol Dial Transplant. 1998;13:930-934.
  26. Vuong M.T, Hahn-Zoric M, Lundberg S, et al. Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy. Kidney Int. 2001;78:1281-1287.
  27. Van der Helm-van Mil A.H, Smith A.C, Pouria S, et al. Immunoglobulin A multiple myeloma presenting with Henoch-Schönlein purpura associated with reduced sialylation of IgA1. Br J Haematol. 2003;122(6):915-917.
  28. Van Hale H.M, Gibson L.E, Schroeter A.L. Henoch-Schönlein vasculitis: direct immunofluorescence study of uninvolved skin. J Am Acad Dermatol. 1986;15(4 Pt 1):665-670.
  29. Faille-Kuyper E.H, Kater L, Kuijten R.H, et al. Occurrence of vascular IgA deposits in clinically normal skin of patients with renal disease. Kidney Int. 1976;9(5):424-429.
  30. Thompson A.J, Chan Y.L, Woodroffe A.J, et al. Vascular IgA deposits in clinically normal skin of patients with renal disease. Pathology. 1980;12(3):407-413.
  31. Hené R.J, Velthuis P, van de Wiel A. et al. The relevance of IgA deposits in vessel walls of clinically normal skin. A prospective study. Arch Intern Med. 1986 Apr;146(4):745-749.
  32. Saklayen M.G, Schroeter A.L, Nafz M.A, Jalil K. IgA deposition in the skin of patients with alcoholic liver disease. J Cutan Pathol. 1996;23(1):12-18.
  33. Мухин Н.А., Гуляев С.В., Кривошеев О.Г. и др. Клиническое и прогностическое значение поражения желудочно - кишечного тракта при системных сосудистых пурпурах. Терапевтический архив. 2003;75(2):50-54.
  34. Bode C, Bode J.C. Effect of alcohol consumption on the gut. Best Pract Res Clin Gastroenterol. 2003;17(4):575-592.
  35. Shwartzman G. A new phenomenon of local skin reactivity to B. Typhosus culture filtrate. Exptl Biol Med. 1928;25(7):560-561.
  36. Кривошеев О.Г. Системные сосудистые пурпуры - клинико - этиологические варианты: Дис. канд. мед. наук. Москва; 1999.
  37. Davin J.C, Forget P, Mahieu P.R. Increased intestinal permeability to (51 Cr) EDTA is correlated with IgA immune complex - plasma levels in children with IgA-associated nephropathies. Acta Paediatr Scand. 1988;77(1):118-124.
  38. Davin J.C, Mahieu P.R. Sequential measurements of intestinal permeability to [51Cr] EDTA in children with Henoch-Schönlein purpura nephritis. Nephron. 1992;60(4):498-499.

Copyright (c) 2018 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies