Minimal hepatic encephalopathy: current clinical and pathogenetic aspects


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Abstract

The review considers modern ideas about the clinic and pathogenesis of minimal hepatic encephalopathy (MHE). It is discussed the present of cognitive impairment in this category of patients. The data of functional MRI are analyzed, and these results allow taking a fresh look at the origin of clinical disorders in this condition. The importance of cerebral connections disruption is emphasized. It is focused on the fact that in the functioning of the central nervous system the spontaneous activity of the brain has a significant importance. Separately is analyzed “the resting state”. It is concluded that MHE, despite its minimal manifestations, is a clinically significant condition requiring attention of a specialists. With that, it is often not diagnosed on time in clinical practice, which could lead to more severe damage of the cerebral functions. As evidenced by the data obtained at the present time, quite extensive changes in the neuronal activity are underlid of the cognitive deficit.

About the authors

I V Damulin

I.M. First Moscow State Medical University, Ministry of Health of Russia; A.S Loginov Moscow clinical scientific center of the Moscow healthcare Department

Email: damulin@mmascience.ru
д.м.н., проф. каф. нервных болезней и нейрохирургии Первого МГМУ им. И.М. Сеченова, вед. науч. сотр. МНКЦ им. А.С. Логинова Moscow, Russia

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