Comparative analysis of ovarian reserve in women with obesity in reproductive period


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Abstract

Objective. To evaluate the ovarian reserve function in female patients with obesity in comparison with women without obesity. Materials and methods. This study evaluated 500 caucasian women, age 20-30 years, 250 with obesity (body mass index, BMI ≥30 kg/m2) and 250 without obesity (BMI <30 kg/m2). Anthropometrics, serum concentrations of anti-Mullerian hormone (AMH), inhibin B, follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, and testosterone were compared as ovarian volume (cm3) and antral follicle count (AFC), determined by ovarian transvaginal ultrasonography. Results and discussion. We reveal statistically significant difference in following parameters: AMH (2.7±0.47 ng/ml vs. 3.8±0.63 ng/ml; p<0.05), testosterone (1.4±0.3 nmol/l vs. 0.7±0.2 nmol/l; p<0.01), ovarian volume (7.2±1.9 cm3 vs 9.5±1.7 cm3; p<0.05), and AFC (13.3±4.5 vs 20.7±7.2; p<0.01) in obesity group vs. control group respectively. Conclusion. Ovarian reserve function is significantly lower in obese patients than in healthy control subjects of young reproductive age, but ovarian reserve parameters are in normal reference range even in obese patients.

About the authors

O R Grigoryan

Scientific Center for Endocrinology, Ministry of Health of Russia

Email: iceberg1995@mail.ru
д.м.н., гл.н.с. отд-ния эндокринной гинекологии Института репродуктивной медицины Эндокринологического научного центра Moscow, Russia

R K Mikheev

Scientific Center for Endocrinology, Ministry of Health of Russia; A.I. Evdokimov Moscow State University of Medicine and Dentistry Ministry of Health of Russia

студент лечебного ф-та МГМСУ им. А.И. Евдокимова Moscow, Russia

E N Andreeva

Scientific Center for Endocrinology, Ministry of Health of Russia; A.I. Evdokimov Moscow State University of Medicine and Dentistry Ministry of Health of Russia

д.м.н., проф., зав. отд-нием эндокринной гинекологии, директор Института репродуктивной медицины Эндокринологического научного центра Moscow, Russia

I I Dedov

Scientific Center for Endocrinology, Ministry of Health of Russia

д.м.н., проф., акад. РАН, директор Эндокринологического научного центра Moscow, Russia

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