Variety of lung involvement in autoimmune liver diseases


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Abstract

The primary autoimmune liver diseases conventionally include primary biliary cholangitis, primary sclerosing cholangitis and autoimmune hepatitis. Despite of primary autoimmune affection of different parts of the hepatobiliary system, in the recent decades, a lot of data has emerged indicating the presence of extrahepatic manifestations of these diseases, in particular, lung lesions, such as nodular and interstitial changes with possible progression and development of fibrosis and respiratory failure. In case of lungs disease, both pulmonary parenchyma and lung vessels, pleura, and intrathoracic lymph nodes can be involved. The most sensitive and specific procedure to assess the extent of the lung lesions and their evolution is high-resolution computed tomography. Due to the possibility of long-term asymptomatic course of the pulmonary disease with development of irreversible changes in patients with autoimmune liver diseases, it seems reasonable to conduct screening studies aimed at early detection and treatment of lung lesions in this population.

About the authors

L A Akulkina

M.V. Lomonosov Moscow State University, Faculty of Base Medicine, Department of Internal medicine

Email: akullar.ru@mail.ru
клин. ординатор каф. внутренних болезней факультета фундаментальной медицины МГУ им. М.В.Ломоносова Москва, Россия

M Yu Brovko

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Tareev clinic of Internal Diseases

Email: michail.brovko@gmail.com
к.м.н., зав. отд-нием пульмонологии и профпатологии, Клиника им. Е.М.Тареева УКБ №3 Первого МГМУ им. И.М. Сеченова Москва, Россия

V I Sholomova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Tareev clinic of Internal Diseases; M.V. Lomonosov Moscow State University, Faculty of Base Medicine, Department of Internal medicine

Email: vsholomova@mail.ru
врач-пульмонолог отд-ния пульмонологии и профпатологии, Клиника им. Е.М.Тареева УКБ №3 Первого МГМУ им. И.М. Сеченова; ассистент каф. внутренних, профессиональных болезней и ревматологии медико-профилактического факультета, Первого МГМУ им. И.М. Сеченова; аспирант каф. внутренних болезней факультета фундаментальной медицины МГУ им. М.В. Ломоносова Москва, Россия

T P Rozina

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Tareev clinic of Internal Diseases; M.V. Lomonosov Moscow State University, Faculty of Base Medicine, Department of Internal medicine

Email: alrozin@yandex.ru
к.м.н., доц. каф. внутренних, профессиональных болезней и ревматологии медико-профилактического факультета Первого МГМУ им. И.М. Сеченова; доц. каф. внутренних болезней факультета фундаментальной медицины МГУ им. М.В.Ломоносова Москва, Россия

A S Yanakayeva

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Tareev clinic of Internal Diseases

Email: yanakaewa@gmail.com
врач-рентгенолог отд-ния лучевой диагностики, Клиника им. Е.М.Тареева УКБ №3 Первого МГМУ им. И.М. Сеченова Москва, Россия

L Ya Frantsuzevich

M.V. Lomonosov Moscow State University, Faculty of Base Medicine, Department of Internal medicine

Email: frantsuzevitch@mail.ru
клин. ординатор каф. внутренних болезней факультета фундаментальной медицины, МГУ им. М.В.Ломоносова Москва, Россия

M V Lebedeva

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Tareev clinic of Internal Diseases

Email: marinaamica@mail.ru
к.м.н., доц. каф. внутренних, профессиональных болезней и ревматологии медико-профилактического факультета Первого МГМУ им. И.М. Сеченова Москва, Россия

V V Fomin

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Faculty of Medicine, Chair of Internal Medicine No.1

Email: fomin@mma.ru
д.м.н., проф., член-корр. РАН, заведующий кафедрой факультетской терапии №1 лечебного факультета Первого МГМУ им. И.М. Сеченова Москва, Россия

References

  1. Martusewicz-Boros M.M, Boros P.W, Wiatr E. Respiratory system involvement in chronic liver diseases. Pol Arch Med Wewn. 2013; 123:635-642. doi: 10.20452/pamw.1980
  2. Lv X, Gao F, Liu Q, Zhang S, Huang Z, Zhu Y, Zong H, Li Q, Li S. Clinical and pathological characteristics of IgG4-related interstitial lung disease. Exp Ther Med. 2018;15:1465-1473. doi: 10.3892/etm. 2017.5554
  3. Al-Mujaini A, Al-Khabori M, Shenoy K, Wali U. Immunoglobulin G4-related disease: An update. Oman Med J. 2018;33:97-103. doi: 10.5001/omj.2018.20
  4. Ramachandraiah V, Aronow W, Chandy D. Pulmonary sarcoidosis: an update. Postgrad Med Taylor & Francis. 2017;129:149-158. doi: 10.1080/00325481.2017.1251818
  5. Mells G.F. Primary biliary cirrhosis: Family, genes, and bugs. Clin Liver Dis. 2014;3:69-73. doi: 10.1002/cld.308
  6. Shen M, Zhang F, Zhang X. Primary Biliary Cirrhosis Complicated With Interstitial Lung Disease: A Prospective Study in 178 Patients. J Clin Gastroenterol. 2009;43:676-679. doi: 10.1093/innovait/inq138
  7. Koksal D, Koksal A.S, Gurakar A. Pulmonary Manifestations among Patients with Primary Biliary Cirrhosis. J Clin Transl Hepatol. 2016;4:258-262. doi: 10.14218/JCTH.2016.00024
  8. Rodriguez-Roisin R, Pares A, Bruguera M, Coll J, Picado C. Pulmonary involvement in primary biliary cirrhosis. Thorax. 1981;36: 208-212.
  9. Uddenfeldt P, Bjerle P, Danielsson A, Nyström L. Lung Function Abnormalities in Patients with Primary Biliary Cirrhosis. Acta Med Scand. 1988;223:549-555.
  10. Krowka M.J, Grambsch P.M, Edell E.S, Cortese D.A, Dickson E.R. Primary biliary cirrhosis: relation between hepatic function and pulmonary function in patients who never smoked. Hepatology. 1991;13:1095-1100.
  11. Costa C, Sambataro A, Baldi S, Modena V, Todros L, Libertucci D, Coni F, Fusaro E, Revello F, Murgia A. Primary biliary cirrhosis: lung involvement. Liver. 1995;15:196-201.
  12. Wallaert B, Bonniere P, Prin L, Cortot A, Tonnel A.B, Voisin C. Primary biliary cirrhosis. Subclinical inflammatory alveolitis in patients with normal chest roentgenograms. Chest. 1986;90:842-848.
  13. Spiteri M.A, Johnson M, Epstein O, Sherlock S, Clarke S.W, Poulter L.W. Immunological features of lung lavage cells from patients with primary biliary cirrhosis may reflect those seen in pulmonary sarcoidosis. Gut. 1990;31:208-212.
  14. Kuś J, Bartosiewicz M, Siemion-Szcześniak I, Jędrych M, Radwan-Röhrenschef P, Lewandowska K, Langfort R, Oniszh K, Franczuk M, Kuś J, Wesołowski S. Interstitial lung disease in patients with primary biliary cirrhosis. Pneumonol Alergol Pol. 2012;80:471-481.
  15. Liu B, Zhang F.C, Zhang Z.L, Zhang W, Gao L.X. Interstitial lung disease and Sjögren’s syndrome in primary biliary cirrhosis: A causal or casual association? Clin Rheumatol. 2008;27:1299-1306. doi: 10.1007/ s10067-008-0917-x
  16. Franco I, Dubini A, Piciucchi S, Casoni G, Poletti V. Interstitial lung disease preceding primary biliary cirrhosis in a male patient. Rev Port Pneumol. 2015;21:214-217. doi: 10.1016/j.rppnen.2015.02.008
  17. Talwalkar J.A, Lindor K.D. Primary biliary cirrhosis. Lancet. 2003;362:53-61. doi: 10.1016/S0140-6736(03)13808-1
  18. Golding P.L, Smith M, Williams R. Multisystem involvement in chronic liver disease. Studies on the incidence and pathogenesis. Am J Med. 1973;55:772-782.
  19. Strobel E.S, Bonnet R.B, Werner P, Schaefer H.E. Clinical Rheumatology Case Report Bronehiolitis Obliterans Organising Pneumonia and Primary Biliary Cirrhosis-Like Lung Involvement in a Patient with Primary Biliary Cirrhosis. Clin Rheumatol. 1998;17:246-249.
  20. Stanley N.N, Woodgate D.J. Mottled chest radiograph and gas transfer defect in chronic liver disease. Thorax. 1972;27:315-323.
  21. Wallace J.G.Jr, Tong M.J, Ueki B.H, Quismorio F.P. Pulmonary involvement in primary biliary cirrhosis. J Clin Gastroenterol. 1987;9(4):431-435.
  22. Chatté G, Streichenberger N, Boillot O, Gille D, Loire R, Cordier J. Lymphocytic bronchitis / bronchiolitis in a patient with primary biliary cirrhosis. Eur Respir J. 1995;8:176-179.
  23. Wallwork J, Williams R, Calne R.Y. Transplantation of liver, heart, and lungs for primary biliary cirrhosis and primary pulmonary hypertension. Lancet. 1987;330:182-185.
  24. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Management of cholestatic liver diseases. J Hepatol. 2009;51:237-267. doi: 10.1016/j.jhep.2009.04.009
  25. La Russo N.F, Shneider B.L, Black D, Gores G.J, James S.P, Doo E, Hoofnagle J.H. Primary sclerosing cholangitis: Summary of a workshop. Hepatology 2006;44:746-764. doi: 10.1002/hep.21337
  26. Jonard P, Geubel A, Wallon J, et al. Primary sclerosing cholangitis and idiopathic pulmonary fibrosis: a case report. Acta Clin. Belg. 1989;44:24-30.
  27. Gossard A.A, Lindor K.D. Autoimmune hepatitis: A review. J Gastroenterol. 2012;47:498-503. doi: 10.1007/s00535-012-0586-z
  28. Ferri C, La Civita L, Fazzi P, Solfanelli S, Lombardini F, Begliomini E, Monti M, Longombardo G, Pasero G, Zignego L. Interstitial lung fibrosis and rheumatic disorders in patients with hepatitis C virus infection. Br J Rheumatol. 1997;36:360-365.
  29. Мухин Н.А., Абдурахманов Д.Т., Лопаткина Т.Н. и др. Схема Саммерскилла в лечении тяжелых форм аутоиммунного гепатита. Клиническая гепатология. 2011;(3):39-45.

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