Atypical Goodpasture’s disease: a clinical case report and literature review


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Abstract

Goodpasture’s disease (anti-GBM disease) is a rare small vessels vasculitis characterized by the presence of autoantibodies directed against the glomerular basement membrane (GBM) and alveolar basement membrane. Common feature of anti-GBM disease is a combination of rapidly progressive glomerulonephritis and alveolar hemorrhage (pulmonary-renal syndrome). We present a case of atypical disease course in a young male patient who developed alveolar hemorrhage without renal failure. The only symptom of renal involvement was isolated hematuria. Plasmapheresis combined with immunosuppression (cyclophosphamide and corticosteroids) was effective. We present a review of state-of-art data on the pathogenesis and disease course of anti-GBM disease.

About the authors

M L Bulanova

Vladimir Regional Clinical Hospital

Email: doctorbulanova@gmail.com
зам. гл. врача по терапевтической службе ГБУЗ ВО «ОКБ» Vladimir, Russia

D V Potapov

Vladimir Regional Clinical Hospital

зав. отд-нием анестезиологии и реанимации ГБУЗ ВО «ОКБ» Vladimir, Russia

N M Bulanov

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

с.н.с. НИО здоровьесберегающих технологий Первого МГМУ им. И.М. Сеченова; ORCID 0000-0002-3989-2590 Moscow, Russia

L V Lysenko(Kozlovskaya)

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

проф. каф. внутренних, профессиональных болезней и пульмонологии Первого МГМУ им. И.М. Сеченова Moscow, Russia

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