HCV-associated mixed cryoglobulinemia and b-cell non-Hodgkin's lymphoma - pathogenetically related problems


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Abstract

Hepatitis C virus (HCV) is a global population problem due to its high prevalence, usually late diagnosis, the difficulties of treatment. In the prognosis of patients with HCV not only hepatic, but increasingly frequent of extrahepatic HCV manifestations, such as mixed cryoglobulinemia (CG), are important. Mixed CG is currently considered as a B-cell benign lymphoproliferative disorders. The role of HCV virus in the pathogenesis of lymphoproliferative diseases is confirmed by a large number of epidemiological studies, as well as by the effectiveness of antiviral therapy in patients with non-Hodgkin’s lymphoma (NHL). The purpose of the review was to provide an overview of recent literature data and the meta-analysis of epidemiological data explaining the role of HCV in the development of NHL. The review also discusses the treatment for HCV-associated NHL by antiviral therapy or other therapeutic options, such as chemotherapy.

About the authors

S Yu Milovanova

I.M. Sechenov First Moscow State Medical Univesity, Ministry Health of Russia (Sechenov University)

Email: sveta@milovanova.ru
д.м.н., в.н.с. НИО здоровьесберегающих технологий Научно-технологического парка биомедицины Первого МГМУ им. И.М. Сеченова Moscow, Russia

L V Lysenko (Kozlovskaya)

I.M. Sechenov First Moscow State Medical Univesity, Ministry Health of Russia (Sechenov University)

проф. каф. внутренних, профессиональных болезней и ревматологии медико-профилактического факультета Первого МГМУ им. И.М. Сеченова Moscow, Russia

L Yu Milovanova

I.M. Sechenov First Moscow State Medical Univesity, Ministry Health of Russia (Sechenov University)

д.м.н., доц. каф. внутренних, профессиональных болезней и ревматологии медико-профилактического факультета Первого МГМУ им. И.М. Сеченова Moscow, Russia

N N Mrykhin

I.M. Sechenov First Moscow State Medical Univesity, Ministry Health of Russia (Sechenov University)

зав. лаб. Университетской клинической больницы (УКБ) № 3 Первого МГМУ им. И.М. Сеченова Moscow, Russia

A V Russkih

Clinical Hospital of Moscow Department of Ministry of Internal Affairs of the Russian Federation Health care Unit

д.м.н., зам. начальника Клинического госпиталя ФКУЗ «Медико-санитарная часть МВД России по г. Москве» Moscow, Russia

N A Muchin

I.M. Sechenov First Moscow State Medical Univesity, Ministry Health of Russia (Sechenov University)

д.м.н., проф., акад. РАН, зав. каф. внутренних, профессиональных болезней и ревматологии медико-профилактического факультета МГМУ им. И.М. Сеченова Moscow, Russia

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