Changes in the indices of prooxidant and antioxidant systems in blood plasma in men with atrophic gastritis and gastric cancer


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Abstract

Aim. To study changes in the indices of prooxidant and antioxidant systems in plasma in men with atrophic gastritis and gastric cancer. Materials and methods. The study included 60 healthy men, 42 patients with atrophic gastritis and 50 men, nicardipine patients with gastric cancer stage II according to TNM. All patients underwent serological diagnosis of diffuse atrophic gastritis (definition of pepsinogens and gastrin-17) and Helicobacter pylori infection. The diagnosis of "atrophic gastritis" was verified by morphological examination of biopsy specimens obtained during fibroesophagogastroduodenoscopy. Diagnosis of gastric cancer was carried out in the Krasnoyarsk regional oncologic dispensary on the basis of a comprehensive instrumental and morphological examination. All patients spectrophotometric methods in plasma was determined the content of diene conjugates (DC), malonic dialdehyde (MDA), glutathione-S-transferase (GST), glutathione peroxidase (GPO), superoxide dismutase (SOD) and catalase. Results. The concentration of SOD, GST, GPO and catalase had no significant differences in patients with atrophic gastritis and gastric cancer and prevailed in comparison with healthy persons. Patients with cancer of the stomach content in the blood plasma DK 2.7 times and MDA at 35.2 times higher than healthy individuals, indicating severe oxidative stress in patients with cancer. In patients with atrophic gastritis was observed similar but less pronounced pattern. Conclusion. The results indicate the presence of oxidative stress in men with atrophic gastritis and gastric cancer.

About the authors

V V Tsukanov

Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science (FRC KSC SB RAS) separate division “Scientific Research Institute of medical problems of the North” (SRI MPN)

д.м.н., проф., зав. клин. отд-нием патологии пищеварительной системы у взрослых и детей Krasnoyarsk

O V Smirnova

Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science (FRC KSC SB RAS) separate division “Scientific Research Institute of medical problems of the North” (SRI MPN)

д.м.н., проф., зав. лаб. клинической патофизиологии Krasnoyarsk

E V Kasparov

Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science (FRC KSC SB RAS) separate division “Scientific Research Institute of medical problems of the North” (SRI MPN)

д.м.н., проф., зам. директора ФИЦ КНЦ СО РАН по научно-организационной работе Krasnoyarsk

A A Sinyakov

Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science (FRC KSC SB RAS) separate division “Scientific Research Institute of medical problems of the North” (SRI MPN)

м.н.с. лаб. клинической патофизиологии Krasnoyarsk

A V Vasyutin

Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science (FRC KSC SB RAS) separate division “Scientific Research Institute of medical problems of the North” (SRI MPN)

к.м.н., с.н.с. клин. отд-ния патологии пищеварительной системы у взрослых и детей Krasnoyarsk

Yu L Tonkikh

Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science (FRC KSC SB RAS) separate division “Scientific Research Institute of medical problems of the North” (SRI MPN)

к.м.н., с.н.с. клин. отд-ния патологии пищеварительной системы у взрослых и детей Krasnoyarsk

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