Overexpression of DNA-methyltransferases in persistency of cccDNA pool in chronic hepatitis B
- Authors: Kostyushev DS1, Zueva AP1,2, Brezgin SA1,3, Lipatnikov AD1,4, Simirskii VN5, Glebe D6, Volchkova EV3, Shipulin GA1, Chulanov VP1,3
-
Affiliations:
- ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора
- ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»
- ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России
- ФГБОУ ВО «Российский химико-технологический университет им. Д.И. Менделеева» Минобрнауки России
- ФГБУН «Институт биологии развития им. Н.К. Кольцова» РАН
- Гессенский университет им. Ю. Либиха
- Issue: Vol 89, No 11 (2017)
- Pages: 21-26
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/32287
- DOI: https://doi.org/10.17116/terarkh2017891121-26
- ID: 32287
Cite item
Full Text
Abstract
Full Text
##article.viewOnOriginalSite##About the authors
D S Kostyushev
ФБУН «Центральный научно-исследовательский институт эпидемиологии» РоспотребнадзораМосква, Россия
A P Zueva
ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора; ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»Москва, Россия
S A Brezgin
ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора; ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава РоссииМосква, Россия
A D Lipatnikov
ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора; ФГБОУ ВО «Российский химико-технологический университет им. Д.И. Менделеева» Минобрнауки РоссииМосква, Россия
V N Simirskii
ФГБУН «Институт биологии развития им. Н.К. Кольцова» РАНМосква, Россия
D Glebe
Гессенский университет им. Ю. ЛибихаГессен, Германия
E V Volchkova
ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава РоссииМосква, Россия
G A Shipulin
ФБУН «Центральный научно-исследовательский институт эпидемиологии» РоспотребнадзораМосква, Россия
V P Chulanov
ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора; ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава РоссииМосква, Россия
References
- Custer B, Sullivan SD, Hazlet TK, Iloeje U, Veenstra DL, Kowdley KV. Global epidemiology of hepatitis B virus. Journal of Clinical Gastroenterology. 2004;38(10,Suppl.3):S158-168. https://doi.org/10.1097/00004836-200411003-00008
- Государственный доклад «О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2013 году». Ссылка активна на 28.11.2016. Доступно по: http://rospotrebnadzor.ru/documents/details.php?ELEMENT_ID=1984
- Levrero M1, Pollicino T, Petersen J, Belloni L, Raimondo G, Dandri M. Control of cccDNA function in hepatitis B virus infection. Journal of Hepatology. 2009;51(3):581-592. https://doi.org/10.1016/j.jhep.2009.05.022
- Nassal M. HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B. Gut. 2015;64(12):1972-1984. https://doi.org/10.1136/gutjnl-2015-309809
- Laras A1, Koskinas J, Dimou E, Kostamena A, Hadziyannis SJ. Intrahepatic levels and replicative activity of covalently closed circular hepatitis B virus DNA in chronically infected patients. Hepatology. 2006;44(3):694-702. https://doi.org/10.1002/hep.21299
- Hung-Chih Yang and Jia-Horng Kao. Persistence of hepatitis B virus covalently closed circular DNA in hepatocytes: molecular mechanisms and clinical significance. Emerging Microbes and Infections. 2014;3(9):e64. https://doi.org/10.1038/emi.2014.64
- Ying Chen, Johnny Sze, and Ming-Liang He. HBV cccDNA in patients’ sera as an indicator for HBV reactivation and an early signal of liver damage. World Journal of Gastroenterology. 2004;10(1):82-85. https://doi.org/10.3748/wjg.v10.i1.82
- Werle-Lapostolle B, Bowden S, Locarnini S, Wursthorn K, Petersen J, Lau G, Trepo C, Marcellin P, Goodman Z, Delaney WE 4th, Xiong S, Brosgart CL, Chen SS, Gibbs CS, Zoulim F. Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology. 2004;126(7):1750-1758. https://doi.org/10.1053/j.gastro.2004.03.018
- Ganem D, Prince AM. Hepatitis B virus infection-natural history and clinical consequences. New England Journal of Medicine 2004;350:1118-1129. https://doi.org/10.1056/nejm200409163511228
- Philipp Tropberger, Alexandre Mercier, Margaret Robinson, Weidong Zhong, Don E Ganem, Meghan Holdorf. Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation. Proceedings of National Academy of Sciences. 2015;112(42): E5715-5724. https://doi.org/0.1073/pnas.1518090112
- Lemonica Koumbi1, and Peter Karayiannis. The Epigenetic Control of Hepatitis B Virus Modulates the Outcome of Infection. Frontiers in Microbiology. 2015;6:1491. https://doi.org/10.3389/fmicb.2015.01491
- Yi Tian, Weibing Yang, Jianxun Song, Yuzhang Wu, and Bing Ni. Hepatitis B Virus X Protein-Induced Aberrant Epigenetic Modifications Contributing to Human Hepatocellular Carcinoma Pathogenesis. Molecular Cell Biology. 2013;33(15):2810-2816. https://doi.org/10.1128/MCB.00205-13
- Perumal Vivekanandan, Hubert Darius-J Daniel, Rajesh Kannangai, Francisco Martinez-Murillo, and Michael Torbenson. Hepatitis B Virus Replication Induces Methylation of both Host and Viral DNA. Journal of Virology. 2010;84(9):4321-4329. https://doi.org/10.1128/JVI.02280-09
- Zhang Y, Mao R, Yan R, Cai D, Zhang Y, Zhu H, Kang Y, Liu H, Wang J, Qin Y, Huang Y, Guo H, Zhang J. Transcription of hepatitis B virus covalently closed circular DNA is regulated by CpG methylation during chronic infection. PLoS One. 2014;9(10): e110442. https://doi.org/10.1371/journal.pone.0110442
- Surbhi Jain, Ting-Tsung Chang, Sitong Chen, Batbold Boldbaatar, Adam Clemens, Selena Y. Lin, Ran Yan, Chi-Tan Hu, Haitao Guo, Timothy M. Block, Wei Song and Ying-Hsiu Su. Comprehensive DNA methylation analysis of hepatitis B virus genome in infected liver tissues. Scientific Reports. 2015;5(10478). https://doi.org/10.1038/srep10478
- Guo Y, Li Y, Mu S, Zhang J, Yan Z. Evidence that methylation of hepatitis B virus covalently closed circular DNA in liver tissues of patients with chronic hepatitis B modulates HBV replication. Journal of Medical Virology. 2009;81(7):1177-1183. https://doi.org/10.1002/jmv.21525
- Saito, Y., Y. Kanai, M. Sakamoto, H. Saito, H. Ishii, and S. Hirohashi. Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology. 2001;33:561-568 https://doi.org/10.1053/jhep.2001.22507
- Sakuma T, Masaki K, Abe-Chayama H, Mochida K, Yamamoto T, Chayama K. Highly multiplexed CRISPR-Cas9-nuclease and Cas9-nickase vectors for inactivation of hepatitis B virus. Genes Cells. 2016;21(11):1253-1262. https://doi.org/10.1111/gtc.12437
- Li H, Sheng C, Liu H, Liu G, Du X, Du J, Zhan L, Li P, Yang C, Qi L, Wang J, Yang X, Jia L, Xie J, Wang L, Hao R, Xu D, Tong Y, Zhou Y, Zhou J, Sun Y, Li Q, Qiu S, Song H. An Effective Molecular Target Site in Hepatitis B Virus S Gene for Cas9 Cleavage and Mutational Inactivation. International Journal of Biological Sciences. 2016;12(9):1104-13. https://doi.org/10.7150/ijbs.16064
- Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science. 2014;343(6176):1221-1228. https://doi.org/10.1126/science.1243462
- Bloom K, Ely A, Mussolino C, Cathomen T, Arbuthnot P. Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases. Molecular Therapy. 2013;21(10):1889-1897. https://doi.org/10.1038/mt.2013.170
- Guo Y1, Li Y, Mu S, Zhang J, Yan Z. Evidence that methylation of hepatitis B virus covalently closed circular DNA in liver tissues of patients with chronic hepatitis B modulates HBV replication. Journal of Medical Virology. 2009;81(7):1177-1183. https://doi.org/10.1002/jmv.21525
- Haiping Li, Fengmei Yang, Bo Gao, Zongtao Yu, Xiaobo Liu, Fei Xie, and Jicai Zhang. Hepatitis B virus infection in hepatocellular carcinoma tissues upregulates expression of DNA methyltransferases. International Journal of Clinical and Experimental Medicine. 2015;8(3):4175-4185.
- Hughes DJ, Marendy EM, Dickerson CA, Yetming KD, Sample CE, Sample JT. Contributions of CTCF and DNA methyltransferases DNMT1 and DNMT3B to Epstein-Barr virus restricted latency. Journal of Virology. 2012;86(2):1034-1045. https://doi.org/10.1128/JVI.05923-11