EBV-positive central nervous system lymphoproliferative disease associated with immunosuppression after organ transplantation: Long-term remission without chemotherapy

O A Gavrilina; Гаврилина О А; V V Troitskaya; Троицкая В В; E E Zvonkov; Звонков Е Е; E N Parovichnikova; Паровичникова Е Н; G M Galstyan; Галстян Г М; L S Biryukova; Бирюкова Л С; I V Nesterenko; Нестеренко И В; A M Kovrigina; Ковригина А М; A V Bazhenov; Баженов А В; V G Savchenko; Гребенюк Л А; V G Savchenko; Савченко В Г

doi:10.17116/terarkh201789769-75

EBV-positive central nervous system lymphoproliferative disease associated with immunosuppression after organ transplantation: Long-term remission without chemotherapy

Authors: Gavrilina OA¹, Troitskaya VV¹, Zvonkov EE¹, Parovichnikova EN¹, Galstyan GM¹, Biryukova LS¹, Nesterenko IV¹, Kovrigina AM¹, Bazhenov AV¹, Savchenko VG¹, Savchenko VG¹
Affiliations:
1. ФГБУ «Гематологический научный центр» Минздрава России
Issue: Vol 89, No 7 (2017)
Pages: 69-75
Section: Editorial
URL: https://journals.rcsi.science/0040-3660/article/view/32285
DOI: https://doi.org/10.17116/terarkh201789769-75
ID: 32285

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Abstract

Primary central nervous system (CNS) lymphomas account for 13-20% of the posttransplant lymphoproliferative disorders (PTLD) and rank among the most aggressive conditions. Reduction of immunosuppressive therapy should be mandatory to treat PTLD, but this is rarely used as the only therapy option. Chemotherapy regimens for PTLD involving the CNS most commonly include high-dose rituximab and high-dose methotrexate and/or cytarabine. The efficiency only of discontinuation of immunosuppressive therapy for PTLD does not exceed 5—10%, but there are no literature data on its efficiency for PTLD involving the CNS. The paper describes a clinical case of achieving long-term remission in a female patient with Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma involving the central nervous system, associated with immunosuppression after kidney transplantation from a related donor, in the absence of chemotherapy during immunosuppressive therapy discontinuation and transplantectomy.

Keywords

diffuse large B-cell lymphoma involving the central nervous system, posttransplant lymphoproliferative diseases, kidney transplantation, immunosuppressive therapy

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EBV-positive central nervous system lymphoproliferative disease associated with immunosuppression after organ transplantation: Long-term remission without chemotherapy

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