The influence of STAT4 rs7574865 (G/T) polymorphism on the risk of clinical and immunological phenotypes of systemic sclerosis in a Russian patient population: Results of a pilot study
- Authors: Krylov MY.1, Ananyeva LP1, Koneva ОА1, Starovoytova MN1, Desinova OV1, Ovsyannikova OB1, Aleksandrova EN1, Novikov AA1, Guseva IA1, Konovalova NV2, Varlamov DA2
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Affiliations:
- ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»
- ФГБНУ «Всероссийский научно-исследовательский институт сельскохозяйственной биотехнологии»
- Issue: Vol 89, No 5 (2017)
- Pages: 20-25
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/32181
- DOI: https://doi.org/10.17116/terarkh201789520-25
- ID: 32181
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##article.viewOnOriginalSite##About the authors
M Yu Krylov
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Москва, Россия
L P Ananyeva
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Москва, Россия
О А Koneva
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Москва, Россия
M N Starovoytova
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Москва, Россия
O V Desinova
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Москва, Россия
O B Ovsyannikova
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Москва, Россия
E N Aleksandrova
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Москва, Россия
A A Novikov
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Москва, Россия
I A Guseva
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Москва, Россия
N V Konovalova
ФГБНУ «Всероссийский научно-исследовательский институт сельскохозяйственной биотехнологии»Москва, Россия
D A Varlamov
ФГБНУ «Всероссийский научно-исследовательский институт сельскохозяйственной биотехнологии»Москва, Россия
References
- Stephanie GY, Kong J, Cheema GS, Keen CL, Wick G, Gershwin ME. The immunobiology of systemic sclerosis. Semin Arthritis Rheum. 2008;38:132-160. doi: 10.1016/j.semarthrit.2007.10.010
- Harley JB, Alarcon-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet. 2008;40:204-210. doi: 10.1016/j.clim.2008.03.252
- Korman BD, Alba MI, Le JM, Alevizos I, Smith JA, Nikolov NP, et al. Variant form of STAT4 is associated with primary Sjo¨gren’s syndrome. Genes Immun. 2008;9:267-270. doi: 10.1038/gene.2008.1
- Martinez A, Varade J, Marquez A, Cenit MC, Espino L, Perdigones N, et al. Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases. Arthritis Rheum. 2008; 58:2598-2602. doi: 10.1002/art.23792
- Remmers EF, Plenge RM, Lee AT, Graham RR, Hom G, Behrens TW, et al. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med. 2007;357:977-986. doi: 10.1056/nejmoa073003
- Kobayashi S, Ikari K, Kaneko H, Kochi Y, Yamamoto K, Shimane K, et al. Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. Arthritis Rheum. 2008;58:1940-1946. doi: 10.1002/art.23494
- Lee HS, Remmers EF, Le JM, Kastner DL, Bae SC, Gregersen PK. Association of STAT4 with rheumatoid arthritis in the Korean population. Mol Med. 2007;13:455-460. doi: 10.2119/2007-00072.Lee
- Watford WT, Hissong BD, Bream JH, Kanno Y, Muul L, O’Shea JJ. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol Rev. 2004;202:139-156. doi: 10.1111/j.0105-2896.2004.00211x
- Sigurdsson S, Nordmark G, Garnier S, Grundberg E, Kwan T, Nilsson O, et al. A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5. Hum Mol Genet. 2008;17:2868-2876. doi: 10.1093/hmg/ddn184
- Varga J, Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest. 2007;117:557-567. doi: 10.1172/JCI31139
- Bunn CC, Black CM. Systemic sclerosis: an autoantibody mosaic. Clin ExpImmunol. 1999;117:207. doi: 10.1046/j.1365-2249.1999.00990.x
- Steen VD. Autoantibodies in systemic sclerosis. Semin Arthritis Rheum. 2005;35:35-42. doi: 10.1016/j.semarthrit.2005.03.005
- Arnett FC, Howard RF, Tan F., et al. Increased prevalence of systemic sclerosis in a Native American tribe in Oklahoma. Association with an Amerindian HLA haplotype. Arthritis Rheum. 1996;39:1362-1370. doi: 10.1002/art.1780390814
- Steen V, Domsic RT, Lucas M, Fertig N, Medsger TA. A clinical and serologic comparison of African-American and Caucasian patients with systemic sclerosis. Arthritis Rheum. 2012;64(9): 2986-2995. doi: 10.1002/art.34482
- Wang J, Assassi S, Guo G, et al. Clinical and serological features of systemic sclerosis in a Chinese cohort. Clin Rheumatol. 2013;32(5):617-621. doi: 10.1007/s10067-012-2145-7
- Radstake TR, Gorlova O, Rueda B, et al. Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nat Genet. 2010;42(5):426-429. doi: 10.1038/ng.565
- Thierfelder WE, van Deursen JM, Yamamoto K. et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature. 1996;382(6487):171-174. doi: 10.1038/382171a0
- Rueda B, Broen J, Simeon C. et al. The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype. Hum Mol Genet. 2009; 18:2071-2077. doi: 10.1093/hmg/ddp119
- Tsuchiya N, Kawasaki A, Hasegawa M. et al. Association of STAT4 polymorphism with systemic sclerosis in a Japanese population. Ann Rheum Dis. 2009;68(8):1375-1376. doi: 10.1136/ard.2009.111310
- Yi L,Wang JC, Guo XJ, Gu YH. et al. STAT4 is a genetic risk factor for systemic sclerosis in a Chinese population. Int J Immunopathol Pharmacol. 2013;26(2):473-478.
- Fukao T, Frucht DM, Yap G, Gadina M, O’Shea JJ, Koyasu S. Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses. J Immunol. 2001;166:4446-4455. doi: 10.4049/jimmunol.166.7.4446
- Avouac J, Fürnrohr BG, Tomcik M., et al. Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis. Arthritis Rheum. 2011; 63:800-809. doi: 10.1002/art.30171