Association of the polymorphic marker Glu23Lys in the KCNJ11 gene with hypertension in Kyrgyz patients


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Abstract

Aim. To study the association of the polymorphic marker Glu23Lys in the KCNJ11 with the development of hypertension in Kyrgyz patients. Subjects and methods. This case-control study enrolled 214 unrelated ethnic Kyrgyzes, in which a study group included 152 hypertensive patients (82 men and 70 women) and a control group consisted of 109 apparently healthy individuals (61 men and 48 women). The examinees’ mean age was 55.2±10.1 years. Hypertension was verified when blood pressure (BP) was above 140/90 mm Hg. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to identify the polymorphic marker Glu23Lys in the KCNJ11 gene. Results. In the hypertension and control groups, the prevalence of 3 genotypes (Glu23Glu, Glu23Lys, and Lys23Lys) of the Glu23Lys polymorphism in the KCNJ11 gene differed significantly (χ2=8.04; p=0.018). The Lys23Lys and Glu23Lys genotypes were statistically more frequently recorded in the hypertension group and the homozygous Glu23Glu genotype was, on the contrary, more common in the control group than in the study one. In the hypertension group, the 23Lys allele frequency was statistically significantly higher than that in the control one (χ2=7.36; p=0.0067). The carriage of the 23Lys allele increased the risk of hypertension by 1.68 times (odds ratio (OR), 1.68; 95% confidence interval (CI), 1.17—2.41), that of the Glu23 allele had, on the contrary, a protective effect (OR, 0.60; 95% CI, 0.41—0.86). Conclusion. The polymorphic marker Glu23Lys in the KCNJ11 gene is associated with hypertension in the Kyrgyzes. The 23Lys allele is a marker for the higher risk of hypertension.

About the authors

Zh T Isakova

Институт молекулярной биологии и медицины

Бишкек, Кыргизская Республика

E T Talaibekova

Институт молекулярной биологии и медицины

Бишкек, Кыргизская Республика

D A Asambaeva

Институт молекулярной биологии и медицины

Бишкек, Кыргизская Республика

A S Kerimkulova

Национальный центр кардиологии и терапии

Бишкек, Кыргизская Республика

O S Lunegova

Национальный центр кардиологии и терапии

Бишкек, Кыргизская Республика

A A Aldashev

Институт молекулярной биологии и медицины

Бишкек, Кыргизская Республика

References

  1. Полупанов А.Г., Концевая А.В., Халматов А.Н., Алтымышева А.Т., Суворова Е.И., Романова Т.А., Худяков М.Б., Шальнова С.А., Джумагулова А.С. Распространенность артериальной гипертензии среди жителей малых городов и сельской местности кыргызской республики: этнические особенности (по данным международного исследования «интерэпид». Кардиоваскулярная терапия и профилактика. 2013;12(6):4-8. doi: 10.15829/1728-8800-2013-6-4-8
  2. Постнов Ю.В., Орлов С.Н. Первичная гипертензия как патология клеточных мембран. М.: Медицина, 1987.
  3. Nichols CG. KATP channels as molecular sensors of cellular metabolism. Nature. 2006; 440(7083): 470-476. doi: 10.1038/nature04711
  4. Zhuo ML, Huang Y, Liu DP, Liang CC. KATP channel: relation with cell metabolism and role in the cardiovascular system. Int J Biochem Cell Biol. 2005;37(4):751-764. doi: 10.1016/j.biocel.2004.10.008
  5. Inagaki N, Gonoi T, Clement JP, Namba N, Inazawa J, Gonzalez G, Aguilar-Bryan L, Seino S, Bryan J. Reconstitution of I (KATP): an inward rectifier subunit plus the sulfonylurea receptor. Science. 1995;270:1166-1170. doi: 10.1126/science.270.5239.1166
  6. Inoue I, Nagase H, Kishi K, Higuti T. ATP-sensitive K+ channel in the mitochondrial inner membrane. Nature. 1999; 352 (6332):244-247. doi: 10.1038/352244a0
  7. McTaggart JS, Clark RH, Ashcroft FM. The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet. Journal of Physiology. 2010;588:17:3201-3209. doi: 10.1113/jphysiol.2010.191767
  8. Riedel MJ, Steckley DC, Light PE. Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes. Hum Genet. 2005;116:133-145. doi: 10.1007/s00439-004-1216-5
  9. Sakamoto Y, Inoue H, Keshavarz P, Miyawaki K, Yamaguchi Y, Moritani M, Kunika K, Nakamura N, Yoshikawa T, Yasui N, Shiota H, Tanahashi T, Itakura M.SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population. J Hum Genet. 2007;52:781-793. doi: 10.1007/s10038-007-0190-x
  10. Koo BK, Cho YM, Park BL, Cheong HS, Shin HD, Jang HC, Kim SY, Lee HK, Park KS. Polymorphisms of KCNJ11 (Kir6.2 gene) are associated with Type 2 diabetes and hypertension in the Korean population. Diabetic Medicine. 2007; 24:178-186. doi: 10.1111/j.1464-5491.2006.02050.x
  11. Миррахимов М.М., Джумагулова А.С., Миррахимов Э.М. Кардиологическая служба Кыргызстана: итоги и перспективы. Здравоохранения Кыргызстана. 1999;1:11-13.
  12. World Health Organization, Regional Office for Europe. European health for all database (HFA-DB). 2006.
  13. Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O’Reilly PF, Amin N, Bragg‐Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH, Aulchenko Y et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011;478:103-109. doi: 10.1038/nature10405
  14. Kokubo Y, Tomoike H, Tanaka C, Banno M, Okuda T, Inamoto N, Kamide K, Kawano Y Miyata T. Association of sixty-one non-synonymous poly-merphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. Hypertension Research. 2006;29:611-619. doi: 10.1291/hypres.29.611
  15. Padmanabhan S, Caulfield M, Dominiczak AF. Genetic and Molecular Aspects of Hypertension. Circulation Research. 2015; 116:937-959. doi: 10.1161/CIRCRESAHA.116.303647
  16. Haghvirdizadeh P, Mohamed Z, Abdullah NA, Haghvirdizadeh P, Haerian MS, Haerian BS. KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus. Journal of Diabetes Research. Volume 2015;Article 908152,9pages. doi: 10.1155/2015/908152
  17. Chistiakov DA, Potapov VA, Khodirev DS, Shamkhalova MS, Shestakova MV, Nosikov VV. Replication of association between polymorphisms of the pancreatic ATP-sensitive potassium channel and susceptibility to type2 diabetes in two Russian urban populations. Cent Eur J Biol. 2010;5(1):67-77. doi: 10.2478/s11535-009-0059-4
  18. Imran Ali Khan, Kiran Kumar Vattam, Parveen Jahan,Kamal Kiran Mukkavali, Qurratulain Hasan, Pragna Rao. Correlation between KCNQ1 and KCNJ11 gene polymorphisms and type 2 and posttransplant diabetes mellitus in the Asian Indian population. Genes&Diseases. 2015;2:276-282. doi: 10.1016/j.gendis.2015.02.009
  19. Reyes S, Terzic A, Mahoney DW, Redfield MM, Rodeheffer RJ, Olson TM. K (ATP) channel polymorphism is associated with left ventricular size in hypertensive individuals: a large-scale community-based study. Hum Genet. 2008;123(6):665-667. doi: 10.1007/s00439-008-0519-3

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