Email this article Clinical and epidemiological characteristics of acute myeloid leukemias in adults according to the data of municipal hematology departments in Moscow
- Authors: Semochkin SV1,2, Tolstykh TN3, Arkhipova NV4, Ivanova VL5, Klyueva OV6, Lunin VV5, Misyurina EN7, Tumanova MV8, Khuazheva NK5
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Affiliations:
- Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России, Москва, Россия
- «РНИМУ им. Н.И. Пирогова» Минздрава России, Москва, Россия
- Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России
- ГКБ №40
- ГКБ им. С.П. Боткина
- ГКБ №81
- ГКБ №52
- «Московский клинический научный центр» департамента здравоохранения Москвы
- Issue: Vol 87, No 7 (2015)
- Pages: 26-32
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/31757
- ID: 31757
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Abstract
Aim. To estimate the incidence of acute myeloid leukemias (AML) in Moscow adults and to evaluate the efficiency of their treatment. Subjects and methods. Data on Moscow residents who were first diagnosed with AML in 2010 were retrospectively collected. The efficiency of their treatment was evaluated from the rates of complete remissions (CR), recurrences, deaths, and 4-year overall (OS) and relapse-free survival (RFS). The data as of September 1, 2013, were analyzed. Results. According to the 2010 pooled materials of the city’s municipal hematology departments, AML (non-M3 types) was diagnosed in 286 patients whose median age at diagnosis was 64.9 years (range, 18.2-92.0 years). The notified incidence rate was 2.9 (3.3 for men and 2.6 for women) cases per 100,000 population. 118 (41%) patients received intensive chemotherapy (ICT); 119 (42%) had chemotherapy with low-dose cytarabine (LDC); 7 (2%) had that with hypomethylating agents (HA); and 42 (15%) had palliative therapy (PT). During first-line therapy, none of the patients underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the entire group, the early (within the first 60 days) mortality rates were 42% (119 deaths); that of patients with primary refractory disease was 32% (90 deaths). CR was achieved in 77 (27%) patients: 57 (48%) on ICT, 17 (14%) on LDC, and 3 (43%) on HA. Recurrences occurred in 37 (48%) of the 77 patients who had achieved CR at a median follow-up of 43.9 months. Four-year OS in all the patients receiving PT was 9.8±1.9% (18.2±3.9% in the patients on ICT versus 4.5±2% in those of LDC; p=0.028); 4-year RFS was 36.1±5.7% (39.6±6.7% in the patients on ICT versus 31.3±11.6% in those on LDC; p=0.8). Conclusion. High mortality rates in the induction, which are caused by the limited resources of accompanying therapy, poor sanitary conditions, and no own opportunities to perform allo-HSCT, remain a key problem of AML therapy in adults.
Keywords
About the authors
S V Semochkin
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России, Москва, Россия; «РНИМУ им. Н.И. Пирогова» Минздрава России, Москва, Россия
T N Tolstykh
Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава РоссииМосква, Россия
N V Arkhipova
ГКБ №40Москва, Россия
V L Ivanova
ГКБ им. С.П. БоткинаМосква, Россия
O V Klyueva
ГКБ №81Москва, Россия
V V Lunin
ГКБ им. С.П. БоткинаМосква, Россия
E N Misyurina
ГКБ №52Москва
M V Tumanova
«Московский клинический научный центр» департамента здравоохранения МосквыМосква, Россия
N K Khuazheva
ГКБ им. С.П. БоткинаМосква, Россия
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