Email this article Thrombosis of the sinus durae matris as a complication of therapy in patients with Hodgkin lymphoma
- Authors: Shitareva IV1, Moiseeva TN1, Al'-Radi LS1, Margolin OV1, Khlavno AB1, Iatsyk GA1, Kravchenko SK1
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Affiliations:
- ФГБУ "Гематологический научный центр" Минздрава России, Москва
- Issue: Vol 86, No 7 (2014)
- Pages: 68-72
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/31546
- ID: 31546
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Abstract
AIM. To describe thrombosis of the sinus durae matris (TSDM) in lymphomas. MATERIALS AND METHODS. 402 patients with Hodgkin lymphoma were treated using the ВЕАСОРР-14 protocol in 2006 to 2013. Thrombotic events occurred in 6% of the patients, including 3 (0.8%) who developed brain magnetic resonance imaging-verified TSDM. RESULTS. TSDM developed in 3 women aged 17, 18, and 25 years during 3-6 chemotherapy cycles involving glucocorticosteroids in a dose of 80 mg/m2 on days 1-7 and an oral contraceptive used continuously for 1.5-3 months. The symptoms of thrombosis were severe headache; 2 patients had convulsive syndrome with short-term loss of consciousness. Anticoagulant therapy with intravenous heparin 20,000-24,000 U/day led to thrombus recanalization within 4-10 days. No rethromoboses were observed during a subsequent follow-up. CONCLUSION. The ВЕАСОРР-14 treatment in young women with Hodgkin lymphoma who continuously take oral contraceptives should be combined with anticoagulant therapy, by monitoring their coagulogram.
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##article.viewOnOriginalSite##About the authors
I V Shitareva
ФГБУ "Гематологический научный центр" Минздрава России, Москва
Email: shitareva@yandex.ru
125167 Москва, Новый Зыковский пр-д, д. 4
T N Moiseeva
ФГБУ "Гематологический научный центр" Минздрава России, Москва
L S Al'-Radi
ФГБУ "Гематологический научный центр" Минздрава России, Москва
O V Margolin
ФГБУ "Гематологический научный центр" Минздрава России, Москва
A B Khlavno
ФГБУ "Гематологический научный центр" Минздрава России, Москва
G A Iatsyk
ФГБУ "Гематологический научный центр" Минздрава России, Москва
S K Kravchenko
ФГБУ "Гематологический научный центр" Минздрава России, Москва
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