电邮这篇文章 Hemostasiological, lipidemic, and hemodynamic indicators associated with the risk of cardiovascular death in high- and very high-risk patients according to the SCORE scale
- 作者: Kachkovskiĭ MA1, Simerzin VV1, Rubanenko OA1, Kirichenko NA1
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隶属关系:
- ГБОУ ВПО "Самарский государственный медицинский университет" Минздрава России
- 期: 卷 86, 编号 3 (2014)
- 页面: 59-64
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/31463
- ID: 31463
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AIM: To identify lipidemic, hemostasiological, and hemodynamic indicators associated with the risk of cardiovascular death in high- and very high-risk patients/MATERIAL AND METHODS: One hundred and forty-eight patients whose mean age was 50.8±4.4 years were examined. All the patients were divided into high (1 group) and very high (2 group) cardiovascular death risk groups according to the SCORE scale. Lipid metabolism, hemostatic system parameters (fibrinogen, time of ADP-induced platelet aggregation initiation, D-dimer), endothelial dysfunction markers (von Willebrand factor), and echocardiographic findings were studied/RESULTS: Multivariate regression analysis showed that the odds ratio for a cardiovascular death risk was 1.8 (95% confidence interval (CI), 1.1 to 4.2; p=0.04) in patients with a D-dimer level of greater than 1 mg/ml, 0.77 (95% CI, 0.6 to 0.97; p=0.03) in those with an ADP-induced platelet aggregation initiation time of 13.5 sec, 1.04 (95% CI, 1.01 to 1.07; p=0.02) in those with an end-diastolic volume of more than 123 ml, 1.1 (95% CI, 1.04 to 1.2; p=0.003) in those with an end-diastolic dimension of more than 51 mm, 1.5 (95% CI, 1.1 to 2.0; p=0.009) in those with a ventricular septal thickness of more than 11.5 mm, and 2.1 (95% CI, 1.03 to 3.2; p=0.0032) in those with a von Willebrand factor level of more than 140%/CONCLUSION: The high levels of von Willebrand factor, D-dimer, ADP-induced platelet aggregation, triglycerides, end-diastolic volume, end-diastolic dimension, and ventricular septal thickness are independent predictors of cardiovascular death in very high-risk patients. These indicators bear out a close relationship between lipid metabolic and hemostatic disturbances and between endothelial dysfunction and intracardiac hemodynamic worsening in these patients.
作者简介
M Kachkovskiĭ
ГБОУ ВПО "Самарский государственный медицинский университет" Минздрава России
V Simerzin
ГБОУ ВПО "Самарский государственный медицинский университет" Минздрава России
O Rubanenko
ГБОУ ВПО "Самарский государственный медицинский университет" Минздрава России
Email: neron@samtel.ru
N Kirichenko
ГБОУ ВПО "Самарский государственный медицинский университет" Минздрава России
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