电邮这篇文章 Current possibilities of correcting subchondral bone resorption as a major pathogenetic factor for progressive osteoarthrosis
- 作者: Naumov AV1
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隶属关系:
- ГБОУ ВПО "Московский государственный медико-стоматологический университет им. А.И. Евдокимова" Минздрава России
- 期: 卷 86, 编号 1 (2014)
- 页面: 60-65
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/31434
- ID: 31434
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详细
The paper considers the current pathogenesis, by choosing the actual targets of pharmacotherapy with available drugs. It reflects the cytokine mechanisms responsible for lesion of the synovial membranes, cartilage, and subchondral bone. Particular emphasis is laid on the role of chondroitin sulfate, glucosamine, vitamin D3 as drugs that affect the key components of pathogenesis, including the volume of resorptive cavities in the subchondral bone.
作者简介
A Naumov
ГБОУ ВПО "Московский государственный медико-стоматологический университет им. А.И. Евдокимова" Минздрава России
Email: nanton78@gmail.com
参考
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- Wildi L., Raynauld J., Martel-Pelletier J. et al. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomized, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis 2011; 70: 982-989.
- Michel B.A., Stucki G., Frey D. et al. Chondroitin 4 and 6 sulfate in osteoarthritis of the knee: A randomized, controlled trial. Arthritis Rheum 2005; 52 (3): 779-786.
- Tat S.K., Pelletier J.-P., Vergés J. et al. Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study. Arthritis Res Ther 2007, 9: R117.
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