Experience with selenium used to recover adrenocortical function in patients taking glucocorticosteroids long


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Abstract

AIM: To study the effect of selenium on adrenocortical function in patients taking glucocorticosteroids (GCS) long/MATERIAL AND METHODS: The study included 56 patients who had been long taking oral GCS for the underlying disease. Adrenocortical function was evaluated by a short synacthen test; adrenal insufficiency (mean cortisol level 8.2 µg/dl) was identified in 52 patients. A study group of patients (n=35) was given selenium 200 µg/day. A control group (n=17) with the detected adrenal insufficiency did not take it. All the patients (n=52) continued to receive standard therapy for the underlying disease, including oral GCS/RESULTS: Adrenal function was reexamined 6 months later; the two paired-samples t-test indicated a statistically significant increase in cortisol levels up to 23.20±4.2 µg/dl (p≤0.05) in the patient group receiving selenium in addition to the basic therapy. In the control group, the function did not recover (cortisol levels were 8.6 and 9.8 µg/dl at baseline and at 6 months, respectively; p≤0.05)/CONCLUSION: The experience with selenium 200 µg/day given long to patients with adrenal insufficiency caused by the long-term use of GCS shows that the agent is effective in recovering adrenocortical function.

About the authors

Iu G Voĭtsekhovskaia

Рижский университет им. П. Страдыня

Email: dr.julia.v@gmail.com

G A Orlikov

Рижский университет им. П. Страдыня

N Voskresenskaia

Центр аллергологии/пульмонологии, Рига; Клиническая университетская больница им. П. Страдыня, Рига

L M Umnova

Рижский университет им. П. Страдыня

I V Ivanov

Рижская 1-я больница

P Gredzena

Клиническая университетская больница им. П. Страдыня, Рига

Iu G Karpov

Рижский университет им. П. Страдыня

Ia Ianovskaia

Рижский университет им. П. Страдыня

V V Voĭtsekhovskiĭ

Рижский университет им. П. Страдыня

É Maulin'sh

Центр аллергологии/пульмонологии, Рига; Рижская 1-я больница

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