Optimization of an approach to solving the problem of a barren marriage in secretory azoospermic men


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Abstract

AIM: To compare the efficiency of using different interventional procedures for a barren marriage in case of secretory azoospermia (SAS)/MATERIAL AND METHODS: The trial enrolled 110 patients aged 25 to 54 years with SAS. The levels of sexual hormones were determined; ovarian punch biopsy was performed/RESULTS: Decreased volume of the ovaries was noted in 85.3% of the patients; diffuse or focal changes in their parenchyma were seen in 65.7%. There was an increase of follicle-stimulating hormone levels and a reduction in testosterone ones. Hyperestrogenemia was identified in 26.5% of the patients. The level of inhibin B was lower in all the patients. The efficiency of standard testicular sperm extraction for cryopreservation was achieved in 28.7% of the patients and that of a microsurgical technique was in 56.7%. The wives of 37 out of the 57 patients included in an assisted reproductive technology program were more than 12 weeks pregnant after 95 intracytoplasmic sperm injection cycles/CONCLUSION: The microsurgical technique is most effective in achieving the successful treatment of patients with azoospermia in order to prevent male infertility.

About the authors

G T Sukhikh

Первый МГМУ им. И.М. Сеченова Минздрава России

S I Gamidov

Первый МГМУ им. И.М. Сеченова Минздрава России; Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России; Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова Минздрава России, Москва

A Iu Popova

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова Минздрава России, Москва

R I Ovchinnikov

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова Минздрава России, Москва

Email: r_ovchinnikov@oparina4.ru, riododc@rambler.ru

D V Shcherbakov

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова Минздрава России, Москва

O M Krasova

Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России

S Kh Izhbaev

Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России

A I Shchegolev

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова Минздрава России, Москва

E A Dubova

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова Минздрава России, Москва

N G Mishieva

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова Минздрава России, Москва

A N Abubakirov

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова Минздрава России, Москва

N S Kamaletdinov

Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова Минздрава России, Москва

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