Multiple myeloma predominantly involving the spleen


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Abstract

Extramedullary disease is an uncommon manifestation in multiple myeloma (MM) and can be observed at onset or develop at disease progression or relapse. Splenic involvement is very rare. The paper describes a 52-year-old female patient with MM who in 1990 was diagnosed with monoclonal gammopathy of undetermined significance with IgGκ secretion and a considerably enlarged spleen. Specific therapy with bortezomib and dexamethasone was initiated in 2006 and proved to be inefficient. After splenectomy there was a 50% reduction in IgGκ concentration. Splenic histological examination revealed monoclonal infiltration by the pleomorphic plasma cells expressing a kappa light chain.

About the authors

V V Ryzhko

Гематологический научный центр Минздрава России, Москва

A A Klodzinskiĭ

Республиканский научный центр неотложной медицинской помощи, Казахстан

A E Grachev

Гематологический научный центр Минздрава России, Москва

E Iu Varlamova

Гематологический научный центр Минздрава России, Москва

M S Sataeva

Республиканский научный центр неотложной медицинской помощи, Казахстан

I M Nakastoev

Гематологический научный центр Минздрава России, Москва

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