Change in the blood cytokine spectrum in patients with pulmonary sarcoidosis


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Abstract

AIM: To assess cytokine spectrum changes in different types of pulmonary sarcoidosis (PS)/MATERIAL AND METHODS: Twenty-seven PS patients without signs of pulmonary fibrosis and 14 patients with sarcoidosis complicated by pulmonary fibrosis were examined. Baseline serum Th1 and Th2 cytokine concentrations were studied. A control group comprised 30 healthy donors/RESULTS: A higher interleukin (IL)-4/IL-2 ratio was found in the peripheral blood of the patients with pulmonary fibrosis-complicated sarcoidosis than in the other patients (326.4±122.6 and 88.2±28.6%, respectively; р=0.002). The sarcoidosis patients with signs of pulmonary fibrosis and no symptoms of disease inflammatory activity had elevated blood IL-1 levels whereas an IL-1 receptor antagonist was decreased/CONCLUSION: In the patients with PS, the development and progression of pulmonary fibrosis occur with a shift in the Th1/Th2 balance towards Th2, which manifests itself as a higher IL-4/IL-2 ratio in the peripheral blood. At the same time, the signs of systemic inflammatory activity remain.

About the authors

S A Terpigorev

МОНИКИ им. М.Ф. Владимирского

Email: smith42@yandex.ru

A A Novikov

НИИ ревматологии РАМН

B A Él' Zeĭn

Первый МГМУ им. И.М. Сеченова

E N Aleksandrova

НИИ ревматологии РАМН

V V Iazdovskiĭ

МОНИКИ им. М.Ф. Владимирского

O V Moskalets

МОНИКИ им. М.Ф. Владимирского

F N Paleev

МОНИКИ им. М.Ф. Владимирского

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