Association between adipokines and the development of osteopenic syndrome in end-stage lung disease


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Abstract

AIM: To study of an association between adipokines, nutritional status, and bone mineral density (BMD) in end-stage lung disease (ESLD). /MATERIAL AND METHODS: Forty-seven patients aged 26 to 62 years with ESLD were examined. BMD in the lumbar spine (LII-LIV) and left femoral neck (FN) was estimated using dual-energy X-ray absorptiometry (DXA). The serum levels of adipokines (leptin, adiponectin resistin, tumor necrosis factor-α (TNF-α), and its receptors sTNFR I, II) were determined. A control group consisted of 45 healthy volunteers matched for age and gender /RESULTS: Osteopenic syndrome (T-score <-1 SD) was recorded in 43 (91%) of the 47 examined patients with ESLD. In lung diseases, the concentrations of adiponectin, resistin, TNF-α, and its receptors were higher and the level of leptin was lower than in the control group. There was a positive correlation between the content of leptin (r=0.64, p=0.0002; r=0.52, p=0.009) and a negative correlation between adiponectin (r=-0.54, p=0.009; r=-0.47, p=0.003), TNF-α (r=-0.43, p=0.03; r=-0.41, p=0.04), and BMD in FN and FN LII-LIV. Correlation analysis showed a positive correlation between the level of resistin (r=0.57; p=0.004), sTNFR I (r=0.42; p=0.03), sTNFR II (r=0.44; p=0.04), and BMD in LII-LIV only. The serum leptin level was positively correlated with body mass index (BMI) (r=0.82; p<0.0001) and total fat mass (TFM) (r=0.84; p<0.0001). On the contrary, the level of adiponectin was inversely correlated with BMI (r=-0.68; p<0.001), serum resistin concentration (r=-0.57; p=0.004), sTNFR I (r=-0.58; p=0.007), and sTNFR II (r=-0.53; p=0.006). It was stated that there was a strong inverse correction between the levels of leptin and adiponectin (r=-0.67; p=0.0008) /CONCLUSION: The found associations between adipokines and BMD may suggest that these markers are implicated in the pathogenesis of osteopenic syndrome in ESLD.

About the authors

E A Kochetkova

Владивостокский государственный медицинский университет

Email: zkochetkova@mail.ru

L G Ugaĭ

Владивостокский государственный медицинский университет

Email: lg.ugay@gmail.com

K A Buria

Владивостокский государственный медицинский университет

Email: k_burya@mail.ru

V A Nevzorova

Владивостокский государственный медицинский университет

Email: nevzorova@inbox.ru

J Massard

Университетская больница, Страсбург, Франция

Email: Gilbert.Massard@chru-strasbourg.fr

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