The incidence of postoperative myocardial infarction and the left ventricular function in patients with type 2 diabetes mellitus after recanalization of chronic coronary occlusions
- Authors: Petrenko IV1, Petrenko OA2, Popova MA3, Mamedova SI1, Urvantseva IA1
-
Affiliations:
- БУ ХМАО-Югры "Окружной кардиологический диспансер "Центр диагностики и сердечно-сосудистой хирургии"
- МУЗ "Городская поликлиника №3", Сургут
- Сургутский государственный университет
- Issue: Vol 84, No 10 (2012)
- Pages: 28-32
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/31099
- ID: 31099
Cite item
Full Text
Abstract
Aim. To study the effects of intracoronary administration of the ischemic preconditioning (IP) trigger adenosine on the reduced incidence of percutaneous coronary intervention (PCI)-associated myocardial infarction (MI) and left ventricular (LV) systolic and contractile function in patients with type 2 diabetes mellitus (DM) during recanalization of chronic coronary occlusions (CCO). Subjects and methods. The patients were divided into 4 groups: 1) 45 patients without DM who received intracoronary placebo infusion; 2) 51 patients without DM who had 10 mg intracoronary adenosine during PCI; 3) 34 patients with type 2 DM who had intracoronary adenosine during PCI; 4) 37 with type 2 DM who received intracoronary placebo. Troponin I and the MB fraction of creatine phosphokinase were measured an hour before and 18-24 hours and 5 days after PCI. The authors estimated the incidence of PCI-associated MI according to the ESC/ACCF/AHA/WHF (2007) criteria and the time course of changes in LV ejection fraction (EF) and end-systolic volume (ESV) and end-diastolic volume, impaired LV local contractility index (ILVLCI) in 167 patients with CCO 1 day and 1 and 12 months after PCI. Results. There was an improvement in myocardial systolic and contractile function after recanalization and stenting for CCO. The intracoronary adenosine groups showed significantly reduced incidence of PCI-associated MI, increased LV EF, and decreased LV ESV and ILVLCI as compared to the placebo groups. Conclusion. The intracoronary injection of the IP trigger adenosine is an effective and safe method to improve LV systolic and contractile function in patients with CCO and type 2 DM.
Full Text
##article.viewOnOriginalSite##About the authors
I V Petrenko
БУ ХМАО-Югры "Окружной кардиологический диспансер "Центр диагностики и сердечно-сосудистой хирургии"
O A Petrenko
МУЗ "Городская поликлиника №3", Сургут628415 Сургут, ул. Ленина, 69/1
M A Popova
Сургутский государственный университет
S I Mamedova
БУ ХМАО-Югры "Окружной кардиологический диспансер "Центр диагностики и сердечно-сосудистой хирургии"
I A Urvantseva
БУ ХМАО-Югры "Окружной кардиологический диспансер "Центр диагностики и сердечно-сосудистой хирургии"
References
- Дедов И.И., Шестакова М.В., Максимова М.А. Федеральная целевая программа "Сахарный диабет": Метод рекоменд. М: Медиа Сфера 2002; 88.
- Elkeles R.S., Diamond J.R., Poulter C. et al. The SENDCAP Study Group. Cardiovascular outcomes in type 2 diabetes. Diabetes Care 1998; 21: 641-648.
- Карпов Ю.А., Шубина А.Т. Поиск новых путей эффективной профилактики сердечно-сосудистых осложнений у больных сахарным диабетом 2-го типа: исследование АDVANCE. Кардиология 2007; 10: 90-95.
- Abizaid А., Costa M.A., Centemero M. et al. Clinical and Economic Impact of Diabetes Mellitus on Percutaneous and Surgical Treatment of Multivessel Coronary Disease Patients. Insights From the Arterial Revascularization Therapy Study (ARTS) Trial. Circulation 2008; 104: 533.
- The BARI 2D Study Group. A randomized trial of therapies for type 2 diabetes and coronary artery disease. N Engl J Med 2009; 360: 2503-2515.
- Safley D.M., House J.A., Rutherford B.D. Success rates of percutaneous coronary intervention of chronic total occlusions and long-term survival in patients with diabetes mellitus. Diabet Vasc Dis Res 2006; 3: 45-51.
- Chistofferson R.D., Lehman K.G., Martin G.V. et al. Effect of chronic total coronary occlusion on treatmentstrategy. Am J Cardiol 2005; 95: 1088-1091.
- Tsuchikane E. The evolution of CTO angioplasty: Lessons learned from the Japanese CTO Club and experience at the Toyohashi Heart Center. Reported at Fifth International Chronic Total Occlusion Summit.
- Suero J.A., Marso S.P., Jones P.G. et al. Procedural Outcomes and Long-Term Survival Among Patients Undergoing Percutaneous Coronary Intervention of a Chronic Total Occlusion in Native Coronary Arteries: A 20-Year Experience. J Am Coll Cardiol 2001; 38: 409-414.
- Testa L., Van Gaal W.J. et al. Myocardial infarction after percutaneous coronary intervention: a meta-analysis of troponin elevation applying the new universal definition. QJM 2009; 102 (6): 369-378.
- Rezkalla S.H., Kloner R.A. Ischemic preconditioning and preinfarction angina in the clinical aren. Nat Clin Pract Cardiovasc Med 2004; 1: 96-102.
- Бокерия Л.А., Чичерин И.Н. Природа и клиническое значение "новых ишемических синдромов". М: НЦССХ им. А.Н. Бакулева РАМН 2007; 302.
- Thygesen K., Alpert J., White Н., on behalf of the Joint ESC/ACCF/AHA/WHF. Task Force for the Redefinition of Myocardial Infarction Universal Definition of Myocardial Infarction the American College of Cardiology Foundation, the American Heart Association, and the World Heart Federation published by Elsevier In.
- Chung C.M., Nakamura S., Tanaka K. et al. Effect of recanalization of chronic total occlusions on global and regional left ventricular function in patients with or without previous myocardial infarction. Catheter Cardiovasc Interv 2003; 60: 368.
- Dzăvik V., Buller C.E., Lamas G.A. et al. Randomized Trial of Percutaneous Coronary Intervention for Subacute Infarct-Related Coronary Artery Occlusion to Achieve Long-Term Patency and Improve Ventricular Function. The Total Occlusion Study of Canada (TOSCA)-2 Trial. Circulation 2006; 114: 1-9.
- Cheng A.S.H., Selvanayagam J.B., Jerosch-Herold M. et al. Percutaneous Treatment of Chronic Total Coronary Occlusions Improves Regional Hyperemic Myocardial Blood Flow and Contractility. JACC 2008; 1 (1): 45-53.
- Epstein S.E., Pichard A.D., Kent K.M. et al. The late open-coronary artery hypothesis: dead, or not definitively tested. Am J Cardiol 2007; 100: 1810-1814.
- Петренко И.В., Попова М.А. Улучшение систолической и сократительной функции миокарда левого желудочка у больных с хроническими окклюзиями коронарных артерий при интракоронарном введении аденозина и озонкислородной смеси. Проф и клин мед 2010; Спец выпуск: 229-235.
- Cohen M.V., Downey J.M. Adenosine: C. Cardioprotection in females: a role for nitric oxide and altered gene expression. Heart Fail Rev 2007; 12: 293-300.
- Leesar M.A., Stoddard M., Ahmed M. et al. Preconditioning of Human Myocardium With Adenosine During Coronary Angioplasty Presented at the 45th Annual Scientific Session of the American College of Cardiology, Orlando, Fla, March 24 to 28. Circulation 1997; 95: 2500-2507.
- Chi-Hang L., Low A., Bee-Choo T. et al. Pretreatment with intracoronary adenosine reduces the incidence of myonecrosis after non-urgent percutaneous coronary intervention: a prospective randomized study. Eur Heart J 2007; 28: 1: 19-25.
- Pantos C., Mourouzis I. Protection of the abnormal heart. Heart Fail Rev 2007; 12: 319-330.
- Penna C., Mancardi D., Raimondo S. et al. The paradigm of postconditioning to protect the heart. J Cell Mol Med 2008; 12 (2): 435-458.
- Cokkinos D.V., Pantos С. Myocardial protection in man - from research concept to clinical practice. Heart Fail Rev 2007; 12: 345-362.
- Depre C., Vatner S.F. Cardioprotection in stunned and hibernating myocardium. Heart Fail Rev 2007; 12: 307-317.
- Дедов И.И. Сахарный диабет: реперфузионные осложнения и проблемы кардиопротекции. Consilium medicum 2006; 9: 55-61.
![](/img/style/loading.gif)