The first results of treatment for adult acute myeloid leukemia according to the AML-01.10 protocol of the Research Group of the Hematology Centers of Russia

E N Parovichnikova; Паровичникова Е Н; G A Kliasova; Клясова Г А; A N Sokolov; Соколов А Н; V V Troitskaia; Троицкая В В; A V Kokhno; Кохно А В; L A Kuz'mina1; Кузьмина Л А; I I Shaforostova; Шафоростова И И; V V Ryzhko; Рыжко В В; S K Kravchenko; Кравченко С К; S N Bondarenko; Бондаренко С Н; V A Lapin; Лапин В А; A S Pristupa; Приступа А С; T S Konstantinova; Константинова Т С; T P Zagoskina; Загоскина Т П; I V Ialykomov; Ялыкомов И В; V I Moskov; Москов В И; L V Anchukova; Анчукова Л В; T S Kaporskaia; Капорская Т С; E M Volodicheva; Володичева Е М; K D Kaplanov; Капланов К Д; E V Kondakova; Кондакова Е В; O S Samoĭlova; Самойлова О С; L V Gavrilova; Гаврилова Л В; S M Kulikov1; Куликов С М; V G Savchenko; Савченко В Г

The first results of treatment for adult acute myeloid leukemia according to the AML-01.10 protocol of the Research Group of the Hematology Centers of Russia

Authors: Parovichnikova EN¹, Kliasova GA¹, Sokolov AN¹, Troitskaia VV¹, Kokhno AV¹, Kuz'mina1 LA¹, Shaforostova II¹, Ryzhko VV¹, Kravchenko SK¹, Bondarenko SN², Lapin VA³, Pristupa AS⁴, Konstantinova TS⁵, Zagoskina TP⁶, Ialykomov IV⁷, Moskov VI⁸, Anchukova LV⁹, Kaporskaia TS¹⁰, Volodicheva EM¹¹, Kaplanov KD¹², Kondakova EV¹³, Samoĭlova OS¹⁴, Gavrilova LV¹⁵, Kulikov1 SM¹, Savchenko VG¹
Affiliations:
1. ФГБУ "Гематологический научный центр" Минздравсоцразвития России, Москва
2. Санкт-Петербургский государственный медицинский университет, Институт детской гематологии и трансплантологии
3. Областная клиническая больница, Ярославль
4. Областная клиническая больница, Рязань
5. Областная клиническая больница, Екатеринбург
6. Кировский НИИ гематологии и переливания крови
7. Областная клиническая больница, Барнаул
8. Краевой онкологический диспансер, Красноярск
9. Областная клиническая больница, Вологда
10. Областная клиническая больница, Иркутск
11. Областная клиническая больница, Тула
12. Областной онкологический диспансер, Волгоград
13. Областная клиническая больница, Сургут
14. Областная клиническая больница, Н. Новгород
15. Городская клиническая больница №4, Саранск
Issue: Vol 84, No 7 (2012)
Pages: 10-15
Section: Editorial
URL: https://journals.rcsi.science/0040-3660/article/view/31036
ID: 31036

Cite item

Abstract

Aim. To give the preliminary results of the AML-01.10 Russian multicenter randomized trial to treat adult acute myeloid leukemia (AML), the basic principle of which is to use high-dose anthracycline antibiotics in induction/consolidation. Subjects and methods. By December 2011, 145 patients with AML had been randomized from 18 hematology centers of 15 cities and towns of the Russian Federation; the median age of all the patients was 44 years. Seventy-one patients were analyzed in August 2011 (a 1.5-year follow-up). Results. The efficiency of 2 courses 7+3 using high-dose daunorubicin (60 mg/m2 per administration) and continuous infusion of cytarabine during the second course was high and comparable with that in the use of a high-dose HAM protocol as a second induction course and can achieve a complete remission in 74.6%. The protocol toxicity evaluated from its early mortality (11.3%) and its death in complete remission (16.6%) was permissible, particularly by taking into consideration the multicenter pattern of the trial. At the completion of analysis, 53 (68.8%) out of the 77 patients on whom the data on their vital status were available were alive. In this follow-up period, the frequency of recurrences was 19.2% (10/52). Only 3 (4.2%) patients out of the 71 patients in whom the efficiency of the protocol had been completely evaluated underwent allogeneic bone marrow transplantation. Conclusion. The total high dose (720 mg/m2) of anthracycline antibiotics, which is used in the period of induction and consolidation, determines the long periods of myelosuppression and intercourse intervals. Protocol deviations (no course of consolidation therapy, lower-dose idarubicin during consolidation therapy, a course of low-dose cytarabine between the courses of induction and consolidation chemotherapy, and very long intercourse intervals) were recorded in a total of 20 (28%) patients.

Keywords

results of the AML-01.10 protocol, high-dose anthracycline antibiotic

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References

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The first results of treatment for adult acute myeloid leukemia according to the AML-01.10 protocol of the Research Group of the Hematology Centers of Russia

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