Efficacy of ivabradin in combined treatment of patients with postinfarction systolic chronic cardiac failure
- Authors: Potapenko A.V.1, Abdulazizov O.S.1, Dyachuk L.I.2, Kiyakbaev G.K.1, Kobalava Z.D.1, Moiseev V.S.1, Potapenko AV3, Abdulazizov OS.3, Dyachuk LI4, Kiyakbaev GK3, Kobalava Z.D3, Moiseev VS3
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Affiliations:
- Российский университет дружбы народов
- ГКБ№ 64
- Russian University of Peoples' Friendship, Moscow
- City Hospital N 64, Moscow
- Issue: Vol 83, No 12 (2011)
- Pages: 19-26
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30930
- ID: 30930
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Full Text
Abstract
Material and methods. A population-based randomized prospective trial enrolled 49 patients (40 males - 81,6%, mean age 63,1 ± 8,1 years) with sinus rhythm and a longer than 3 month history of MI. The patients were randomized into 2 groups: 23 patients of group 1 received standard treatment plus ivabradin, 26 patients of group 2 received standard treatment alone. Follow-up was 36,1 ± 6,2 months. We analysed the trend in heart rate (HR), blood pressure (BP), parameters of echocardiography, ECG, levels of electrolytes, creatinin in blood plasma, frequency of hospitalizations, recurrent non-fatal MI and lethality (combined end point). Results. In the end of the trial ivabradin significantly decreased HR from 71 to 64 b/m. Frequency of combined end point of efficacy was 30,4 and 50% in group 1 and 2, respectively. In group 1 primary end point in high baseline HR occurred more frequently than in HR < 70 b/m in 6 (50%) and 1 (9,1%) cases, respectively, but these differences were not significant (p = 0,068). In group 2 the differences were significant - 9 (90%) and 4 (25%) cases, respectively (p = 0,004). By none of the parameters of ECG, plasma electrolytes, creatinine level significant intergroup differences were found. Conclusion. In the same trend in BP and ECG, group 1 patients showed significant and more pronounced HR lowering than group 2 patients. Addition of ivabradin to standard treatment of SCCF after MI promoted less frequency of hospitalizations, recurrent non-fatal MI, fatal cardiovascular events. This effect was especially strong in high baseline HR.
About the authors
Anton Valer'evich Potapenko
Российский университет дружбы народов
Email: medicol@rambler.ru
аспирант каф. факультетской терапии Российского университета дружбы народов; Российский университет дружбы народов
Olimzhon Sharifzhanovich Abdulazizov
Российский университет дружбы народов
Email: alimjan007@mail.ru
аспирант каф. факультетской терапии Российского университета дружбы народов; Российский университет дружбы народов
Larisa Ivanovna Dyachuk
ГКБ№ 64
Email: Cardio-Heart@yandex.ru
врач-ординатор ГКБ № 64; ГКБ№ 64
Gayrat Kaluevich Kiyakbaev
Российский университет дружбы народов
Email: gayratk@rambler.ru
д-р мед. наук, проф. каф. факультетской терапии; Российский университет дружбы народов
Zhanna Davidovna Kobalava
Российский университет дружбы народов
Email: zkobalava@mail.ru
д-р мед. наук, проф., зав. каф. пропедевтики внутренних болезней; Российский университет дружбы народов
Valentin Sergeevich Moiseev
Российский университет дружбы народов
Email: vmoiseev37@mail.ru
д-р мед. наук, акад. РАМН, проф., зав. каф. факультетской терапии; Российский университет дружбы народов
A V Potapenko
Russian University of Peoples' Friendship, MoscowRussian University of Peoples' Friendship, Moscow
O Sh Abdulazizov
Russian University of Peoples' Friendship, MoscowRussian University of Peoples' Friendship, Moscow
L I Dyachuk
City Hospital N 64, MoscowCity Hospital N 64, Moscow
G K Kiyakbaev
Russian University of Peoples' Friendship, MoscowRussian University of Peoples' Friendship, Moscow
Zh D Kobalava
Russian University of Peoples' Friendship, MoscowRussian University of Peoples' Friendship, Moscow
V S Moiseev
Russian University of Peoples' Friendship, MoscowRussian University of Peoples' Friendship, Moscow
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