The extent of coronary stenosis and the level of antibodies to atherogenic lipoproteins in patients with coronary heart disease


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Abstract

Aim. To study association between the level of antibodies to oxidized low-density lipoproteins (anti-OLDL) and the extent of coronary stenosis (CS) in patients with coronary heart disease (CHD).
Material and methods. Sixty CHD patients were examined for titer of anti-OLDL, levels of total cholesterol (TC), LDLP cholesterol, HDLP cholesterol, triglycerides. Selective coronarography (SC) was made on demand.
Results. Elevated titer of anti-OLDL was found only in 12 examinees. It was significantly lower in CHD women than in men. No significant differences by anti-OLDL were found in CHD patients with and without significant risk factors. SC registered in all CHD examinees local stenosis of different severity. Stenosis in 3 coronary arteries was detected in 31 cases, in 2 coronary arteries - in 14, in 1 coronary artery - in 15 patients, most frequently the affection was located in the diagonal branch of the left coronary artery. Stenosis of the left coronary artery trunk was diagnosed in one case. The correlation analysis revealed a strongly significant positive correlation between content of anti-OLDL and the degree of CS.
Conclusion. The level of anti-OLDL in CHD patients directly correlates with the degree of CS and is a marker of coronary atherosclerosis severity.

About the authors

Soreyya Asafovna Urazgil'deeva

ГОУ ВПО СПбГМА им. И. И. Мечникова Росздрава

Email: s_urazgildeeva@hotmail.com
Кафедра кардиологии- канд. мед. наук, доц. каф. кардиологии ФПК ГОУВП СПбМА им. И. И. Мечникова; консультант Центра атеросклероза и нарушений липидного обмена ФГУЗ клиническая больница № 122 им. Л. Г. Соколова, тел./ факс 8-812-559-97-59; ГОУ ВПО СПбГМА им. И. И. Мечникова Росздрава

Aleksandr Yur'evich Titkov

ФГУЗ Клиническая больница № 122 им. Л. Г. Соколова ФМБА РФ

Email: alextitkov76@mail.ru
канд. мед. наук, зав. отд-нием рентгеноэндоваскулярной хирургии и интервенционной кардиологии ВГУЗ клиническая больница № 122 им. Л. Г. Соколова, тел.: 8-812-558-94-68; ФГУЗ Клиническая больница № 122 им. Л. Г. Соколова ФМБА РФ

Lyubov' Vasil'evna Vasina

ФГУЗ Клиническая больница № 122 им. Л. Г. Соколова ФМБА РФ

Email: lubov.vasina@gmail.com
д-р мед. наук, врач-лаборант биохимической лаб. ФГУЗ клиническая больница № 122 им. Л. Г. Соколова, тел.: 8-812-558-94-68; ФГУЗ Клиническая больница № 122 им. Л. Г. Соколова ФМБА РФ

Viktoriya Vital'evna Tsaregorodtseva

ГОУ ВПО СПбГМА им. И. И. Мечникова Росздрава

Email: vika.ru@rambler.ru
Кафедра кардиологии- клинический ординатор каф. кардиологии ФПК ГОУВП СПбГМА им. И. И. Мечникова; ГОУ ВПО СПбГМА им. И. И. Мечникова Росздрава

Viktor Savel'evich Gurevich

ГОУ ВПО СПбГМА им. И. И. Мечникова Росздрава

Email: ater@med122.com
Кафедра кардиологии- д-р мед. наук, проф. каф. кардиологии ФПК ГОУВП СПбГМА им. И. И. Мечникова, рук. Центра атеросклероза и нарушений липидного обмена ФГУЗ клиническая больница № 122 им. Л. Г. Соколова; ГОУ ВПО СПбГМА им. И. И. Мечникова Росздрава

S A Urazgildeeva

I.I. Mechnikov State Medical Academy, Center for Atherosclerosis and Lipid Disorders, St-Petersburg

I.I. Mechnikov State Medical Academy, Center for Atherosclerosis and Lipid Disorders, St-Petersburg

A Yu Titkov

L.G. Sokolov city hospital № 122, St-Petersburg

L.G. Sokolov city hospital № 122, St-Petersburg

L V Vasina

L.G. Sokolov city hospital № 122, St-Petersburg

L.G. Sokolov city hospital № 122, St-Petersburg

V V Tsaregorodtseva

I.I. Mechnikov State Medical Academy, Center for Atherosclerosis and Lipid Disorders, St-Petersburg

I.I. Mechnikov State Medical Academy, Center for Atherosclerosis and Lipid Disorders, St-Petersburg

V S Gurevich

I.I. Mechnikov State Medical Academy, Center for Atherosclerosis and Lipid Disorders, St-Petersburg

I.I. Mechnikov State Medical Academy, Center for Atherosclerosis and Lipid Disorders, St-Petersburg

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