Efficacy of combined treatment of patients with severe obstructive sleep apnea and arterial hypertension of the second and third degree
- Authors: Sukmarova Z.N.1, Litvin A.Y.1, Chazova I.E.1, Rogoza A.N.1, Sukmarova ZN2, Litvin AY.2, Chazova IE2, Rogoza AN2
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Affiliations:
- ФГУ РКНПК Минздравсоцразвития, Москва, Россия
- Cardiological Research Center, Moscow
- Issue: Vol 83, No 5 (2011)
- Pages: 61-66
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30866
- ID: 30866
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Full Text
Abstract
Material and methods. A total of 58 patients aged 55.5±9.6 years participated in the study. Clinical blood pressure (BP) before treatment was 172.0 (170.7-175.9)/100.0 (98.5-104.2) mm Hg, apnea/ hypopnea index was 26.3 episodes an hour. The patients received amlodipin in combination with walsartan in a dose 5-10/160 mg with addition of 25 mg hydrochlorothiaside if target BP was not achieved. This treatment was followed for 3 weeks by CPAP-therapy. Monitoring was made of clinical BP, central BP, target mean 24-h pressure.
Results. Despite a significant reduction of systolic arterial pressure/diastolic arterial pressure (by 30/ 14 mm Hg) as a result of antihypertensive treatment, this reduction was lower than in such patients without obstructive sleep apnea (by data from other investigators). CPAP-therapy reduced the number of resistant patients from 58 to 31%, patients with masked AH - from 19 to 11%, cases of arrhythmia - from 69 to 47%.
Conclusion. Multicomponent pathophysiologically sound AHT in hypertensive patients with severe obstructive sleep apnea was effective in less than 42% cases. The maximal effect was achieved in combined treatment with CPAP-therapy.
About the authors
Zul'fiya Nailevna Sukmarova
ФГУ РКНПК Минздравсоцразвития, Москва, Россияаспирантка Отдела системных гипертензий ФГУ РКНПК Росмедтехнологий, тел.: 8-495-414-63-05; ФГУ РКНПК Минздравсоцразвития, Москва, Россия
Aleksandr Yur'evich Litvin
ФГУ РКНПК Минздравсоцразвития, Москва, Россияд-р мед. наук, ст. науч. сотр. Отдела системных гипертензий, тел.: 8-495-414-68-34; ФГУ РКНПК Минздравсоцразвития, Москва, Россия
Irina Evgen'evna Chazova
ФГУ РКНПК Минздравсоцразвития, Москва, Россияд-р мед. наук, проф., рук. Отдела системных гипертензий, тел.: 8-495-414-63-05; ФГУ РКНПК Минздравсоцразвития, Москва, Россия
Anatoliy Nikolaevich Rogoza
ФГУ РКНПК Минздравсоцразвития, Москва, Россияд-р мед. наук, проф., рук. Отдела методов исследования, тел.: 8-495-414-60-63; ФГУ РКНПК Минздравсоцразвития, Москва, Россия
Z N Sukmarova
Cardiological Research Center, MoscowCardiological Research Center, Moscow
A Yu Litvin
Cardiological Research Center, MoscowCardiological Research Center, Moscow
I E Chazova
Cardiological Research Center, MoscowCardiological Research Center, Moscow
A N Rogoza
Cardiological Research Center, MoscowCardiological Research Center, Moscow
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