A protective effect of Gly272Ser polymorphism of GNB3 gene in development of essential hypertension and its relations with environmental hypertension risk factors
- Authors: Polonikov A.V.1, Solodilova M.A.1, Ivanov V.P.1, Shestakov A.M.2, Ushachev D.V.2, Vyalykh E.K.2, Vasil'eva O.V.1, Polyakova N.V.1, Antsupov V.V.1, Kabanina V.A.1, Kupriyanova Y.S.1, Bulgakova I.V.1, Kozhukhov M.A.2, Tevs D.S.2, Polonikov AV3, Solodilova MA3, Ivanov VP3, Shestakov AM4, Ushachev DV4, Vyalykh EK4, Vasilyeva OV3, Polyakova NV3, Antsupov VV3, Kabanina VA3, Kupriyanova Y.S3, Bulgakova IV3, Kozhukhov MA4, Tevs DS4
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Affiliations:
- Курский государственный медицинский университет
- Курская областная клиническая больница
- State Medical University, Kursk
- Regional hospital, Kursk
- Issue: Vol 83, No 4 (2011)
- Pages: 55-60
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30851
- ID: 30851
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Abstract
Material and methods. We studied DNA samples obtained from 205 EH patients and 207 healthy individuals. EH patients were treated in Kursk hospitals. Genotyping of GNB3 gene polymorphisms was conducted by polymerase chain reaction and restriction analysis.
Results. Prevalence of 825T allele of GNB3 gene in EH patients and healthy individual was 0.334 and 0.295, respectively, of 272S allele - 0.037 and 0.058, respectively. We found no significant differences by prevalence of genotypes of gene GNB3 polymorphisms C825T and G272S in EH patients and healthy individuals. Non-smoking carriers of 272GS genotype had a low risk of EH (OR 0.42 in 95% CI from 0.18 to 0.97; p = 0.04). Smokers had no protective effect of this genotype. The protective effect of 272GS genotype was also found in individuals with low or moderate alcohol drinking habits (OR 0.29 in 95% CI from 0.11 to 0.77, p = 0.02) and in individuals without chronic exposure to stress (OR 0.29 in 95% CI from 0.09 to 0.91, p = 0.04). In contrast, hard drinkers and patients exposed to chronic stress had no protective effect of heterozygous genotype 272GS of gene GNB3.
Conclusion. G272S polymorphism of GNB3 gene can be considered as a new genetic marker of predisposition to EH. The protective effect depends of environmental factors associated with high risk to develop EH.
About the authors
Aleksey Valer'evich Polonikov
Курский государственный медицинский университет
Email: polonikov@rambler.ru
д-р мед. наук, проф. каф. биологии, мед. генетики и экологии Курского государственного медицинского университета; Курский государственный медицинский университет
Mariya Andreevna Solodilova
Курский государственный медицинский университет
Email: m-solodilova@rambler.ru
д-р биол. наук, проф. каф. биологии, мед. генетики и экологии Курского государственного медицинского университета; Курский государственный медицинский университет
Vladimir Petrovich Ivanov
Курский государственный медицинский университет
Email: medbiol@kursknet.ru
д-р мед. наук, проф., зав. каф. биологии, медицинской генетики и экологии; Курский государственный медицинский университет
Aleksandr Mikhaylovich Shestakov
Курская областная клиническая больница
Email: shestakof@yandex.ru
врач-кардиолог Курской областной клинической больницы; Курская областная клиническая больница
Dmitriy Vladimirovich Ushachev
Курская областная клиническая больница
Email: okb@sovtest.ru
врач-кардиолог Курской областной клинической больницы; Курская областная клиническая больница
Ekaterina Konstantinovna Vyalykh
Курская областная клиническая больница
Email: kate-yours@mail.ru
врач-генетик Курской областной клинической больницы; Курская областная клиническая больница
Oksana Vladimirovna Vasil'eva
Курский государственный медицинский университет
Email: vovpost@kursknet.ru
канд. биол. наук, ст. преподаватель каф. биологии, медицинской генетики и экологии; Курский государственный медицинский университет
Natal'ya Vladimirovna Polyakova
Курский государственный медицинский университет
Email: medbiol@kursknet.ru
аспирант каф. зоологии и теории эволюции; Курский государственный медицинский университет
Vladimir Vladimirovich Antsupov
Курский государственный медицинский университет
Email: medbiol@kursknet.ru
аспирант каф. зоологии и теории эволюции; Курский государственный медицинский университет
Valentina Aleksandrovna Kabanina
Курский государственный медицинский университет
Email: medbiol@kursknet.ru
студентка леч. фак-та Курского государственного медицинского университета; Курский государственный медицинский университет
Yana Sergeevna Kupriyanova
Курский государственный медицинский университетстудентка леч. фак-та; Курский государственный медицинский университет
Irina Viktorovna Bulgakova
Курский государственный медицинский университетстудентка леч. фак-та; Курский государственный медицинский университет
Mikhail Alekseevich Kozhukhov
Курская областная клиническая больница
Email: okb@sovtest.ru
канд. мед. наук, гл. врач Курской областной клинической больницы; Курская областная клиническая больница
Dmitriy Sergeevich Tevs
Курская областная клиническая больница
Email: okb@sovtest.ru
врач-ординатор Курской областной клинической больницы; Курская областная клиническая больница
A V Polonikov
State Medical University, KurskState Medical University, Kursk
M A Solodilova
State Medical University, KurskState Medical University, Kursk
V P Ivanov
State Medical University, KurskState Medical University, Kursk
A M Shestakov
Regional hospital, KurskRegional hospital, Kursk
D V Ushachev
Regional hospital, KurskRegional hospital, Kursk
E K Vyalykh
Regional hospital, KurskRegional hospital, Kursk
O V Vasilyeva
State Medical University, KurskState Medical University, Kursk
N V Polyakova
State Medical University, KurskState Medical University, Kursk
V V Antsupov
State Medical University, KurskState Medical University, Kursk
V A Kabanina
State Medical University, KurskState Medical University, Kursk
Ya S Kupriyanova
State Medical University, KurskState Medical University, Kursk
I V Bulgakova
State Medical University, KurskState Medical University, Kursk
M A Kozhukhov
Regional hospital, KurskRegional hospital, Kursk
D S Tevs
Regional hospital, KurskRegional hospital, Kursk
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