Development of acute myeloid leukemia from donor cells after allogenic peripheral blood stem cell transplantation in a female patient with acute monoblastic leukemia

Ol'ga Olegovna Shchegolevataya; Щеголеватая Ольга Олеговна; Elena Nikolaevna Parovichnikova; Паровичникова Елена Николаевна; I A Demidova; Демидова И А; Valentin Grigor'evich Isaev; Исаев Валентин Григорьевич; Andrey Nikolaevich Sokolov; Соколов Андрей Николаевич; Evgeniya Ivanovna Zhelnova; Желнова Евгения Ивановна; I V Alekseeva; Алексеева И В; V A Zherebtsova; Жеребцова В А; T V Gaponova; Гапонова Т В; Elena Vasil'evna Domracheva; Домрачева Елена Васильевна; Andrey Vital'evich Misyurin; Мисюрин Андрей Витальевич; L P Poreshina; Порешина Л П; I B Kaplanskaya; Капланская И Б; Elena Nikolaevna Ustinova; Устинова Елена Николаевна; Elena Olegovna Gribanova; Грибанова Елена Олеговна; Valeriy Grigor'evich Savchenko; Савченко Валерий Григорьевич; O O Schegolevataya; Schegolevataya O O; E N Parovichnikova; Parovichnikova E N; I A Demidova; Demidova I A; V G Isaev; Isaev V G; A N Sokolov; Sokolov A N; E I Zhelnova; Zhelnova E I; I V Alekseeva; Alekseeva I V; V A Zherebtsova; Zherebtsova V A; T V Gaponova; Gaponova T V; E V Domracheva; Domracheva E V; A V Misyurin; Misyurin A V; L P Poreshina; Poreshina L P; I B Kaplanskaya; Kaplanskaya I B; E N Ustinova; Ustinova E N; E O Gribanova; Gribanova E O; V G Savchenko; Savchenko V G

Development of acute myeloid leukemia from donor cells after allogenic peripheral blood stem cell transplantation in a female patient with acute monoblastic leukemia

Authors: Shchegolevataya O.O.¹, Parovichnikova E.N.¹, Demidova IA¹, Isaev V.G.¹, Sokolov A.N.¹, Zhelnova E.I.¹, Alekseeva IV¹, Zherebtsova VA¹, Gaponova TV¹, Domracheva E.V.¹, Misyurin A.V.¹, Poreshina LP¹, Kaplanskaya IB¹, Ustinova E.N.¹, Gribanova E.O.¹, Savchenko V.G.¹, Schegolevataya OO², Parovichnikova EN², Demidova IA², Isaev VG², Sokolov AN², Zhelnova EI², Alekseeva IV², Zherebtsova VA², Gaponova TV², Domracheva EV², Misyurin AV², Poreshina LP², Kaplanskaya IB², Ustinova EN², Gribanova EO², Savchenko VG²
Affiliations:
1. Гематологический научный центр РАМН
2. Hematology Research Center, Russian Academy of Medical Sciences, Moscow
Issue: Vol 83, No 3 (2011)
Pages: 57-62
Section: Editorial
URL: https://journals.rcsi.science/0040-3660/article/view/30839
ID: 30839

Cite item

Abstract

Development of leukemia from donor cells is a rare complication of allogeneic blood stem cells (BSC). The paper describes a case of evolving acute myeloid leukemia of a graft in a patient with resistant acute monoblastic leukemia after related allogeneic peripheral BSC transplantation. The rarity of this complication, difficulties in providing evidence for the donor origin of a leukemic clone demonstrate a need for all-round careful dynamic assessment of the hematopoietic system after allogeneic transplantation, by applying the current cytogenetic (fluorescence in situ hybridization) and molecular (hypervariable genomic region amplification test using the polymerase chain reaction, hypervariable number of tandem repeats (VNTR), and short number of tandem repeats (STR)) techniques, which permits errors to be avoided in the assessment of a clinical situation and in the diagnosis of leukemia from donor cells. There is no developed policy for treatment of acute graft-versus-leukemia.

Keywords

acute myeloid leukemia, acute monoblastic leukemia, allogeneic peripheral blood stem cells transplantation, leukemia from donor cells

References

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Development of acute myeloid leukemia from donor cells after allogenic peripheral blood stem cell transplantation in a female patient with acute monoblastic leukemia

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