Email this article Cardiovascular risk factors in psoriatic and rheumatoid arthritis
- Authors: Rebrov A.P.1, Nikitina N.M.1, Gaydukova I.Z.2, Rebrov AP3, Nikitina NM3, Gaidukova IZ4
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Affiliations:
- ГОУ ВПО Саратовский ГМУ им. В. И. Разумовского Росздрава
- ГУЗ Саратовская областная клиническая больница с патологоанатомическим центром
- State Medical University, Saratov
- Regional hospital, Saratov
- Issue: Vol 83, No 5 (2011)
- Pages: 20-24
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30832
- ID: 30832
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Abstract
Aim. To study the role of conventional and new factors of cardiovascular risk in development of atherosclerosis in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PA).
Material and methods. Sixty patients with psoriatic arthritis, 414 RA patients and 79 healthy controls entered the trial. All of them had no manifestations of cardiovascular diseases. Screening was made of the leading risk factors of cardiovascular diseases and cardiovascular complications, thickness of the complex intima-media (TIM) of the carotid arteries, vascular wall stiffness were measured, vasoregulatory function of the endothelium, markers of endothelial damage were examined.
Results. Patients with psoriatic and rheumatoid arthritis were found to have increased TIM of the carotid arteries, high incidence of atherosclerotic plaques, increased stiffness, damage of the vascular wall, affected endothelial vasoregulation. These alterations were associated with high arthritis activity, systemic manifestations, seropositivity by rheumatoid factor (in RA), presence of entesitis, uveitis and dactilitis (in psoriatic arthritis), dislipidemia, arterial hypertension (AH).
Conclusion. To determine cardiovascular risk in patients with arthritis, it is necessary to consider not only standard risk factors (dislipidemia and AH), but also severity of systemic inflammation, arterial stiffness, endothelial damage and ability of the vascular wall to relax reflecting endothelial dysfunction.
Material and methods. Sixty patients with psoriatic arthritis, 414 RA patients and 79 healthy controls entered the trial. All of them had no manifestations of cardiovascular diseases. Screening was made of the leading risk factors of cardiovascular diseases and cardiovascular complications, thickness of the complex intima-media (TIM) of the carotid arteries, vascular wall stiffness were measured, vasoregulatory function of the endothelium, markers of endothelial damage were examined.
Results. Patients with psoriatic and rheumatoid arthritis were found to have increased TIM of the carotid arteries, high incidence of atherosclerotic plaques, increased stiffness, damage of the vascular wall, affected endothelial vasoregulation. These alterations were associated with high arthritis activity, systemic manifestations, seropositivity by rheumatoid factor (in RA), presence of entesitis, uveitis and dactilitis (in psoriatic arthritis), dislipidemia, arterial hypertension (AH).
Conclusion. To determine cardiovascular risk in patients with arthritis, it is necessary to consider not only standard risk factors (dislipidemia and AH), but also severity of systemic inflammation, arterial stiffness, endothelial damage and ability of the vascular wall to relax reflecting endothelial dysfunction.
About the authors
Andrey Petrovich Rebrov
ГОУ ВПО Саратовский ГМУ им. В. И. Разумовского Росздрава
Email: andreyrebrov@yandex.ru
д-р мед. наук, проф., зав. каф. госпитальной терапии лечебного факультета, Саратовский ГМУ им. В. И. Разумовского, тел.: (8452(51-49-60); ГОУ ВПО Саратовский ГМУ им. В. И. Разумовского Росздрава
Natal'ya Mikhaylovna Nikitina
ГОУ ВПО Саратовский ГМУ им. В. И. Разумовского Росздравад-р мед. наук, доц., каф. госпитальной терапии лечебного факультета, Саратовский ГМУ им. В. И. Разумовского; ГОУ ВПО Саратовский ГМУ им. В. И. Разумовского Росздрава
Inna Zurabievna Gaydukova
ГУЗ Саратовская областная клиническая больница с патологоанатомическим центромврач, отд-ние ревматологии, Саратовская областная клиническая больница с ПЦ; ГУЗ Саратовская областная клиническая больница с патологоанатомическим центром
A P Rebrov
State Medical University, SaratovState Medical University, Saratov
N M Nikitina
State Medical University, SaratovState Medical University, Saratov
I Z Gaidukova
Regional hospital, SaratovRegional hospital, Saratov
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