Acute lymphoblastic leukemias with translocations (1;19)(q23;p13): a description of 3 new cases and a review of the literature

  • Authors: Gindina T.L.1, Mamaev N.N.1, Zubaydullina S.R.2, Kondakova E.V.3, Gindina TL4, Mamayev NN4, Zubaidullina SR5, Kondakova EV6
  • Affiliations:
    1. Институт детской гематологии и трансплантологии костного мозга имени Р. М. Горбачевой при Санкт-Петербургском государственном медицинском университете им. акад. И. П. Павлова
    2. Окружной кардиологический диспансер
    3. Сургутская окружная клиническая больница
    4. R. M. Gorbacheva Institute of Pediatric Hematology and Transplantology, Acad. I. P. Pavlov Saint Petersburg State Medical University
    5. Medical Genetic Counseling Center, District Cardiology Dispensary
    6. Surgut District Clinical Hospital
  • Issue: Vol 82, No 11 (2010)
  • Pages: 63-67
  • Section: Editorial
  • URL: https://journals.rcsi.science/0040-3660/article/view/30755
  • ID: 30755

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Abstract

Aim. To discuss the specific features of the cytogenetics and clinical manifestations of acute lymphoblastic leukemias (ALL) with balanced and unbalanced translocations (1;19)(q23; p13).
Materials and methods. Bone marrow cells with differential staining of chromosomes into G-segments underwent cytogenetic study that was added by fluorescence in situ hybridization in 2 cases. The karyotypes of 3 patients with ALL previously untreated at 5, 18, and 23 years of age were studied.
Results. Balanced translocations (1;19)(q23; p13) were found in 2 of the examinees while unbalanced translocation was noted in 1 case. Modal chromosomal classes were 46, 47, and 55-65 if the cells had additional structural (+1q, 6q-, etc.) and numerical chromosomal abnormalities (nonrandom trisomies and tetrasomies of chromosomes of different pairs).
Conclusion. Translocation (1;19)(q23; p13) is characteristic for patients of different age groups, mainly for those with pre-B cell ALL. It is commonly concurrent with other karyotypic changes, namely, 6q deletion, 1q trisomy, and high hyperdiploidy.

About the authors

Tat'yana Leonidovna Gindina

Институт детской гематологии и трансплантологии костного мозга имени Р. М. Горбачевой при Санкт-Петербургском государственном медицинском университете им. акад. И. П. Павлова

Email: tatgindina@rambler.ru
канд. мед. наук, врач-лаборант, генетик, лаб. цитогенетики, Центр Детской гематологии и трансплантологии им. Р. М. Горбачевой, Санкт-Петербургский Государственный медицинский университет им. акад. И. П. Павлова, тел.: 8-812-233-12-43; Институт детской гематологии и трансплантологии костного мозга имени Р. М. Горбачевой при Санкт-Петербургском государственном медицинском университете им. акад. И. П. Павлова

Nikolay Nikolaevich Mamaev

Институт детской гематологии и трансплантологии костного мозга имени Р. М. Горбачевой при Санкт-Петербургском государственном медицинском университете им. акад. И. П. Павлова

Email: nikmamaev@rambler.ru
д-р мед наук, проф., каф. клинической и лабораторной диагностики с курсом молекулярной медицины, зав. лаб. цитогенетики, Центр Детской гематологии им. Р. М. Горбачевой, Санкт-Петербургский Государственный медицинский университет им. акад. И. П. Павлова, тел.: 8-812-234-46-25; Институт детской гематологии и трансплантологии костного мозга имени Р. М. Горбачевой при Санкт-Петербургском государственном медицинском университете им. акад. И. П. Павлова

Svetlana Rafikovna Zubaydullina

Окружной кардиологический диспансер

Email: svetuk_s@mail.ru
Лаборатория цитогенетики медико-генетической консультации- аспирант, каф. госпитальной терапии медицинского факультета, Сургутский Государственный Университет, тел.: 8-3462-51-45-11; Окружной кардиологический диспансер

Elena Viktorovna Kondakova

Сургутская окружная клиническая больница

Email: kondakovae@mail.ru
Отделение гематологии- аспирант, каф. госпитальной терапии медицинского факультета, Сургутский Государственный Университет, тел.: 8-3462-52-71-86; Сургутская окружная клиническая больница

T L Gindina

R. M. Gorbacheva Institute of Pediatric Hematology and Transplantology, Acad. I. P. Pavlov Saint Petersburg State Medical University

R. M. Gorbacheva Institute of Pediatric Hematology and Transplantology, Acad. I. P. Pavlov Saint Petersburg State Medical University

N N Mamayev

R. M. Gorbacheva Institute of Pediatric Hematology and Transplantology, Acad. I. P. Pavlov Saint Petersburg State Medical University

R. M. Gorbacheva Institute of Pediatric Hematology and Transplantology, Acad. I. P. Pavlov Saint Petersburg State Medical University

S R Zubaidullina

Medical Genetic Counseling Center, District Cardiology Dispensary

Medical Genetic Counseling Center, District Cardiology Dispensary

E V Kondakova

Surgut District Clinical Hospital

Surgut District Clinical Hospital

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