Effect of the anti-inflammatory peptide preparation ingramon on the blood levels of acute-phase proteins and chemokines in patients after coronary stenting

Aleksandra Viktorovna Potekhina; Потехина Александра Викторовна; Sergey Il'ich Provatorov; Проваторов Сергей Ильич; Tat'yana Igorevna Aref'eva; Арефьева Татьяна Игоревна; Nadezhda Borisovna Kukhtina; Кухтина Надежда Борисовна; Valeriy Pavlovich Masenko; Масенко Валерий Павлович; Elena Ivanovna Kaznacheeva; Казначеева Елена Ивановна; Natal'ya Yur'evna Ruleva; Рулева Наталья Юрьевна; Elena Aleksandrovna Noeva; Ноева Елена Александровна; Mariya Konstantinovna Osyaeva; Осяева Мария Константиновна; Mariya Vladimirovna Sidorova; Сидорова Мария Владимировна; Zhanna Dmitrievna Bespalova; Беспалова Жанна Дмитриевна; Tat'yana Leonidovna Krasnikova; Красникова Татьяна Леонидовна; A V Potekhina; Potekhina A V; S I Provatorov; Provatorov S I; T I Arefyeva; Arefyeva T I; N B Kukhtina; Kukhtina N B; V P Masenko; Masenko V P; E I Kaznacheyeva; Kaznacheyeva E I; N Yu Ruleva; Ruleva N Yu; E A Noyeva; Noyeva E A; M K Osyaeva; Osyaeva M K; M V Sidorova; Sidorova M V; Zh D Bestalova; Bestalova Zh D; T L Krasnikova; Krasnikova T L

Effect of the anti-inflammatory peptide preparation ingramon on the blood levels of acute-phase proteins and chemokines in patients after coronary stenting

Authors: Potekhina A.V.¹, Provatorov S.I.¹, Aref'eva T.I.¹, Kukhtina N.B.¹, Masenko V.P.¹, Kaznacheeva E.I.¹, Ruleva N.Y.¹, Noeva E.A.¹, Osyaeva M.K.¹, Sidorova M.V.¹, Bespalova Z.D.¹, Krasnikova T.L.¹, Potekhina AV², Provatorov SI², Arefyeva TI², Kukhtina NB², Masenko VP², Kaznacheyeva EI², Ruleva NY.², Noyeva EA², Osyaeva MK², Sidorova MV², Bestalova Z.D², Krasnikova TL²
Affiliations:
1. ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий
2. Russian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies
Issue: Vol 82, No 11 (2010)
Pages: 58-63
Section: Editorial
URL: https://journals.rcsi.science/0040-3660/article/view/30752
ID: 30752

Cite item

Abstract

Aim. To study the effect of the anti-inflammatory peptide preparation ingramon on the peripheral blood levels of inflammatory markers in patients with exercise-induced stable angina after coronary stenting (CS).
Subjects and methods. The investigation enrolled 64 patients with stable angina who had undergone coronary bypass surgery, of them 34 patients received ingramon in addition to standard therapy. The blood levels of high-sensitive C-reactive protein (hs-CRP), fibrinogen, the chemokines MCP-1, IL-8, IP-10, and MID were measured before and 1, 2, and 7 days and 1, 3, and 6 months after surgery. Twenty patients who had gone coronarography (CG) only were examined as a control group.
Results. In the postCS patients receiving only standard therapy, the levels of hs-CRP and fibrinogen were much higher on days 1, 2, and 7 after surgery than in the CG patients. On day 1 following CS, the increment in hs-CRP correlated with the length of implanted stents. During ingramon therapy, the content of hs-CRP and fibrinogen was considerably lower on days 1, 2, and 7 after CS than in the control group; this trend persisted a month after surgery; there was also a reduction in MCP-1 levels within the first 24 hours after initiation of therapy. The levels of the chemokines IP-10, MIG, and IL-8 were significantly unchanged.
Conclusion. When added to standard therapy, ingramon exerts a positive effect against risk factors for coronary heart disease (CHD) and its events. Further investigations are required to define the impact of ingramon therapy on prognosis in patients with CHD.

Keywords

coronary stenting, inflammation, MCP-1, chemokines, C-reactive protein, ingramon

References

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Effect of the anti-inflammatory peptide preparation ingramon on the blood levels of acute-phase proteins and chemokines in patients after coronary stenting

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